Role of inflammation in the socioeconomic inequalities of neurocognitive disorders

Gireesh, Aswathikutty; Sacker, Amanda; McMunn, Anne; Cadar, Dorina

doi:10.1016/j.bbi.2023.07.013

Cited by 3 publications

(1 citation statement)

References 63 publications

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“…Moreover, in ammation's in uence has been explored concerning the associations between socioeconomic position, social isolation [20], and depression, particularly in older adults [21,22]. However, these insights highlight the need for more focused research on how in ammation mediates the transition from stroke to subsequent dementia.…”

Section: Introductionmentioning

confidence: 99%

Stroke and its diagnosis age on incidence dementia, and the mediating role of inflammation: A matched cohort study

Yang,

Chang,

Qin

et al. 2024

Preprint

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Background We aimed to determine whether and to what extent the joint effect of stroke and age of stroke diagnosis on incident dementia, and to investigate whether inflammation indicators mediate the stroke-dementia relationship. Methods We conducted a nationwide, population-based, matched cohort analysis using data from the UK Biobank. The study examined a total of 13,712 individuals who had suffered a stroke (7,712 incident stroke, 6,000 prevalent stroke). Multivariable Cox proportional hazards models were employed to investigate the association between stroke and dementia risk. The relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP), and synergy index (SI) were calculated to measure the interaction on the additive scale. Longitudinal mediation analysis was conducted to assess the potential mediating effect of inflammation on the association between stroke and dementia, stratified by the age at stroke diagnosis. Competing risk models and propensity score matching were utilized in sensitivity analysis. Results: The median follow-up time was 4.76 years (range: 2.05-8.39) for the incident stroke cohort and 19.07 years (range: 15.87-23.97) for the prevalent stroke cohort. After stroke and non-stroke matching, younger patients exhibited a higher risk of post-stroke dementia compared to older patients, particularly in females and those with non-O blood type. For stroke survivors, older age at stroke onset was associated with higher risks of developing all-cause dementia (HR per 10-year increase, 3.41; 95% CI, 2.84-4.10), and 44%-47% of the combined risk was due to an additive interaction of stroke and its diagnosis age. Chronic inflammation mediated the stroke-dementia association, accounting for 5.4–5.8% of the overall impact in stroke survivors. Conclusion: In addition to confirming that stroke significantly elevates the risk of dementia and that an earlier age at stroke diagnosis augments dementia risk, our study underscores the joint effect of stroke and diagnosis age and inflammation may play a role in this relationship, advocating for early interventions and targeted therapeutic strategies for stroke survivors.

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Section: Introductionmentioning

confidence: 99%

Stroke and its diagnosis age on incidence dementia, and the mediating role of inflammation: A matched cohort study

Yang,

Chang,

Qin

et al. 2024

Preprint

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Identifying the mediating role of inflammation on the relationship between socioeconomic status and Alzheimer’s disease: a Mendelian randomization analysis and mediation analysis

Geng,

Meng,

Tang

2024

J Neurol

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Association of Gum Treatment with Cognitive Decline and Dementia Risk among Older Adults with Periodontal Symptoms: A 12-Year Prospective Cohort Study

Qi,

Zhu,

Wang

et al. 2024

Neuroepidemiology

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Introduction: This study examines the associations of gum treatment with cognitive decline and dementia risk among older adults with periodontal symptoms in the US. Methods: A cohort of 866 adults aged ≥50 with periodontal symptoms was recruited for the 2008 Health and Retirement Study “Dental Health Experimental Module” and followed until 2020. Cognitive function was assessed with the Telephone Interview for Cognitive Status (TICS). Dementia status was ascertained with the Langa-Weir algorithm based on TICS scores and proxy assessments. Linear mixed-effects model and multivariable Cox regression models were utilized to analyze the associations of gum treatment with cognitive decline and the risk of dementia, respectively. Results: Of 866 participants (mean age 67.7, 61.4% women), 105 (12.1%) developed dementia with a median 9 (IQR, 6-10) years follow-up. The dementia incidence rates were lower in the group with gum treatment (7.4 vs. 12.9 per 1,000 person-years). Compared with participants who did not have gum treatment, those with gum treatment experienced a decline in TICS score that was on average 0.025 (95% CI, 0.005-0.044) points less per year and a 38% lower incidence of dementia (Hazard Ratio, 0.62; 95% CI, 0.41-0.93). These associations were consistent across participants with different severity of periodontal symptoms and sociodemographic characteristics (age, sex, race, ethnicity, and education) except for income levels. Conclusion: Prompt gum treatment for older adults with periodontal symptoms may be beneficial for their cognitive health.

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Role of inflammation in the socioeconomic inequalities of neurocognitive disorders

Cited by 3 publications

References 63 publications

Stroke and its diagnosis age on incidence dementia, and the mediating role of inflammation: A matched cohort study

Stroke and its diagnosis age on incidence dementia, and the mediating role of inflammation: A matched cohort study

Identifying the mediating role of inflammation on the relationship between socioeconomic status and Alzheimer’s disease: a Mendelian randomization analysis and mediation analysis

Association of Gum Treatment with Cognitive Decline and Dementia Risk among Older Adults with Periodontal Symptoms: A 12-Year Prospective Cohort Study

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