Role of inflammation in diabetic cardiomyopathy

Ramesh, Pranav; Yeo, Jian L; Brady, Emer M; McCann, Gerry P

doi:10.1177/20420188221083530

Cited by 39 publications

(21 citation statements)

References 83 publications

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“…In 1974, the Framingham Heart Study showed that the risk of heart failure was five times higher in people with type 2 diabetes (T2D) (Kannel et al, 1974). T2D and DCM include markers of inflammation such as TNF⍺, IL-6, IL-8, IL-1β, and C-reactive protein (CRP) (Soinio et al, 2006;Bruno et al, 2009;Dinh et al, 2009;Herder et al, 2011;Ramesh et al, 2022). Another pathway activated in diastolic dysfunction associated with DCM is the renin-angiotensin-aldosterone system (RAAS).…”

Section: Cardiomyopathymentioning

confidence: 99%

Inflammation, dysregulated iron metabolism, and cardiovascular disease

Rosenblum

2023

Front. Aging

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Iron is an essential trace element associated with both pathologic deficiency and toxic overload. Thus, systemic and cell iron metabolism are highly controlled processes regulated by protein expression and localization, as well as turnover, through the action of cytokines and iron status. Iron metabolism in the heart is challenging because both iron overload and deficiency are associated with cardiac disease. Also associated with cardiovascular disease is inflammation, as many cardiac diseases are caused by or include an inflammatory component. In addition, iron metabolism and inflammation are closely linked. Hepcidin, the master regulator of systemic iron metabolism, is induced by the cytokine IL-6 and as such is among the acute phase proteins secreted by the liver as part of the inflammatory response. In an inflammatory state, systemic iron homeostasis is dysregulated, commonly resulting in hypoferremia, or low serum iron. Less well characterized is cardiac iron metabolism in general, and even less is known about how inflammation impacts heart iron handling. This review highlights what is known with respect to iron metabolism in the heart. Expression of iron metabolism-related proteins and processes of iron uptake and efflux in these cell types are outlined. Evidence for the strong co-morbid relationship between inflammation and cardiac disease is also reviewed. Known connections between inflammatory processes and iron metabolism in the heart are discussed with the goal of linking inflammation and iron metabolism in this tissue, a connection that has been relatively under-appreciated as a component of heart function in an inflammatory state. Therapeutic options connecting inflammation and iron balance are emphasized, with the main goal of this review being to bring attention to alterations in iron balance as a component of inflammatory diseases of the cardiovascular system.

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Section: Cardiomyopathymentioning

confidence: 99%

Inflammation, dysregulated iron metabolism, and cardiovascular disease

Rosenblum

2023

Front. Aging

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“…Following NF-κB activation, deleterious inflammatory processes ensue in the myocardium of patients with DM, including cardiomyocyte hypertrophy, fibrosis, and apoptosis, as well as the impairment of myocardial energetics, calcium management, and contractility [ 59 ]. Several human studies have suggested that an augmented systemic inflammatory burden could be predictive of incident HF in individuals with DM.…”

Section: The Role Of Diabetes Mellitus In Heart Failure Pathophysiologymentioning

confidence: 99%

Diabetes Mellitus and Heart Failure: Epidemiology, Pathophysiologic Mechanisms, and the Role of SGLT2 Inhibitors

Theofilis

Oikonomou

Tsioufis

et al. 2023

Life

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Diabetes mellitus (DM) and heart failure (HF) are frequently encountered afflictions that are linked by a common pathophysiologic background. According to landmark studies, those conditions frequently coexist, and this interaction represents a poor prognostic indicator. Based on mechanistic studies, HF can be propagated by multiple pathophysiologic pathways, such as inflammation, oxidative stress, endothelial dysfunction, fibrosis, cardiac autonomic neuropathy, and alterations in substrate utilization. In this regard, DM may augment myocardial inflammation, fibrosis, autonomic dysfunction, and lipotoxicity. As the interaction between DM and HF appears critical, the new cornerstone in DM and HF treatment, sodium-glucose cotransporter-2 inhibitors (SGLT2i), may be able to revert the pathophysiology of those conditions and lead to beneficial HF outcomes. In this review, we aim to highlight the deleterious pathophysiologic interaction between DM and HF, as well as demonstrate the beneficial role of SGLT2i in this field.

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“…Low-grade inflammation is a pathophysiologic factor in type 2 diabetes (T2D) and may have a significant impact on the development of diabetic complications, such as cardiovascular disease (CVD) [ 106 , 107 , 108 ]. GLP-1 suppresses inflammation and promotes gut mucosal integrity [ 10 , 109 ].…”

Section: Glp-1 and Glp-2 As Regulators Of Intestine Integrity And Inf...mentioning

confidence: 99%

GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk

Abdalqadir

Adeli

2022

Microorganisms

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The intestine represents the body’s largest interface between internal organs and external environments except for its nutrient and fluid absorption functions. It has the ability to sense numerous endogenous and exogenous signals from both apical and basolateral surfaces and respond through endocrine and neuronal signaling to maintain metabolic homeostasis and energy expenditure. The intestine also harbours the largest population of microbes that interact with the host to maintain human health and diseases. Furthermore, the gut is known as the largest endocrine gland, secreting over 100 peptides and other molecules that act as signaling molecules to regulate human nutrition and physiology. Among these gut-derived hormones, glucagon-like peptide 1 (GLP-1) and -2 have received the most attention due to their critical role in intestinal function and food absorption as well as their application as key drug targets. In this review, we highlight the current state of the literature that has brought into light the importance of GLP-1 and GLP-2 in orchestrating intestine–microbiota–immune system crosstalk to maintain intestinal barrier integrity, inflammation, and metabolic homeostasis.

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Role of inflammation in diabetic cardiomyopathy

Cited by 39 publications

References 83 publications

Inflammation, dysregulated iron metabolism, and cardiovascular disease

Inflammation, dysregulated iron metabolism, and cardiovascular disease

Diabetes Mellitus and Heart Failure: Epidemiology, Pathophysiologic Mechanisms, and the Role of SGLT2 Inhibitors

GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk

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