Role of Inflammation in Carcinogenesis

Menkin, Valy

doi:10.1136/bmj.1.5186.1585

Cited by 28 publications

(10 citation statements)

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“…Menkin (1960) suggested that a growthpromotion factor, which he believed to be present in inflammatory exudate, acts in conjunction with scar tissue to produce excessive growth and finally the features of malignancy. I n this respect a varicose ulcer lies midway between a healed scar and an osteomyelitic sinus in malignant potential.…”

mentioning

confidence: 98%

Two Unusual Leg Ulcers

Fawcett

Harrison

1972

Journal of British Surgery

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mentioning

confidence: 98%

Two Unusual Leg Ulcers

Fawcett

Harrison

1972

Journal of British Surgery

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“…The three year survival for a well differentiated lesion is about 90% where as it is around 14% for a poorly differentiated lesion [6]. The presence of lymph nodal metastasis increases the mortality rate to about 65% in burn scars [5].…”

Section: Case Reportmentioning

confidence: 99%

“…Trauma, infection, solar exposure, chemicals in wound exudates and burnt tissues caused by cell lysis have all been implicated as co-carcinogens in the development of scar carcinoma for their role in causing parenchymal, cellular, nuclear and nucleic acid damages in a scar [1,[3][4][5].…”

Section: Case Reportmentioning

confidence: 99%

Squamous cell carcinoma arising in a median sternotomy scar—a case report and a brief review of literature

Gnanamuthu

Shukla

Thankatchen

et al. 2010

Indian J Thorac Cardiovasc Surg

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A 71 year old gentleman presented with a nodular growth in the upper end of a median sternotomy scar 17 years after an uneventful cardiac surgery. In the months immediately following the surgery he had itching over the scar and there was an episode of superficial infection in the scar two years hence. He presented this time with a history of itching, ulceration and nodule formation in the upper end of the old surgical scar over the last five months. On examination there was an ulcer at the top end of the sternotomy scar containing a three centimetre diameter nodular growth. He underwent a wide excision biopsy of the lesion which was reported as squamous cell carcinoma. Carcinomas are known to arise from scars of diverse aetiologies, but to our knowledge this is only the second time in the English literature a squamous cell carcinoma has been reported arising from a sternotomy scar.

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“…Neue Aspekte ffir den Entstehungsmechanismus bringen Arbeiten von Menking [5], der im Zusammenhang mit Methylchlorantren im Tierexperiment Tumoren induzieren konnte. t]bereinstimmend wird ffir das Entstehen car-cinomat6ser Ver/inderungen in einer Fistel eine Auskleidung des Fistelganges mit Epithel vorausgesetzt.…”

Section: Diskussionunclassified

Chronische Osteomyelitis und Fistelcarcinom

Wening

Stein

et al. 1989

Langenbecks Arch Chiv

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Malignant change following chronic osteomyelitis with draining sinuses is rare (0.38-2.7%). The time from onset of osteomyelitis until malignant changes differs but needs 30 years in an average. Most patients are men between 50 and 60 years of age. If there is any doubt about malignancy (bleeding, tumor growth) biopsy should be performed and repeated if histological findings give no clear diagnosis. Metastases should be excluded by x-ray of the chest, scintigram and CT of the regional lymphnodes. Correct surgical therapy can only be done by amputation or exarticulation of the extremity. Patients who were operated upon malignant carcinoma of a sinus after osteomyelitis ought to be controlled in a regular follow-up including blood test (tumor marker).

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Role of Inflammation in Carcinogenesis

Cited by 28 publications

References 1 publication

Two Unusual Leg Ulcers

Two Unusual Leg Ulcers

Squamous cell carcinoma arising in a median sternotomy scar—a case report and a brief review of literature

Chronische Osteomyelitis und Fistelcarcinom

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