Role of Inflammation and the NF-κB Signaling Pathway in Hirschsprung’s Disease
Enas Zoheer Elkrewi,
Ahmad A. Al Abdulqader,
Rasul Khasanov
et al.
Abstract:Hirschsprung’s disease (HSCR, incidence 1/5000 live births) is caused by the failure of neural crest-derived precursors to migrate, survive, proliferate, or differentiate during the embryonic development of the Enteric Nervous System (ENS), which could be disrupted by many factors, including inflammatory processes. The NF-κB family controls several biological processes, including inflammation, neurogenesis, and cell migration. With the aim of studying the potential role of NF-κB in HSCR, we have analyzed the e… Show more
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