Role of incremental doses of intracoronary adenosine for fractional flow reserve assessment

Diagnostic Performance of a Novel Cadmium-Zinc-Telluride Gamma Camera System Assessed Using Fractional Flow Reserve

“…From the technical point of view, FFR will be artificially high in a submaximum hyperemic condition, and stenosis severity may be underestimated. 42 Therefore, we excluded patients with severe left LV hypertrophy, such as from aortic stenosis or hypertrophic cardiomyopathy. In addition, FFR cut-offs have not been established in patients with acute myocardial infarction or on chronic hemodialysis.…”

Physiological Assessment of Coronary Artery Disease in the Cardiac Catheterization Laboratory

“…Moreover, FFR, unlike CFR, is independent of gender and CAD risk factors such as hypertension and diabetes, and it varies less with common doses of adenosine than does CFR. 21 A nonischemic threshold value has been prospectively confirmed 19 and was compared with noninvasive stress testing. 20,22 An FFR Ͻ0.75 is associated with inducible ischemia (specificity, 100%), whereas a value Ͼ0.80 indicates absence of inducible ischemia in the majority of patients (sensitivity, 90%).…”

Comparison of Intracoronary Versus Intravenous Administration of Adenosine for Measurement of Coronary Fractional Flow Reserve

“…1,[5][6][7] Most frequently, a bolus injection of 40 μg adenosine for the right coronary artery and 80 μg for the left coronary artery has been used. [8][9][10] There is only limited data, which validates the intracoronary application of adenosine against standard intravenous infusion. We therefore systematically compared FFR measurements during intracoronary and intravenous application of adenosine in 114 consecutive patients and evaluated both the agreement between the 2 application routes as well as the intraindividual variability of each method.…”