Role of immunoglobulin E and gastro-esophageal reflux disease in the development of otitis media with effusion

Gomaa, Mohamed; Karim, Abdel Rahim Ahmed Abdel; Elsherbeny, Yaser Makram

doi:10.1016/j.otpol.2013.08.002

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…In a prospective study, the serum and effusion IgE levels were positively correlated, while the serum and effusion pepsinogen 1 (PG1) levels were negatively correlated (with an effusion level of 1/10 in serum) in 30 pediatric patients with SOM, suggesting that allergic reaction is a risk factor for SOM development. 27 Similar results were reported by Karyanta et al 28 They reported that the SOM prevalence ratio was 4.5 times greater for subjects with and without laryngopharyngeal reflux, suggesting that gastroesophageal reflux is a SOM risk factor.…”

Section: Discussionsupporting

confidence: 81%

Interleukin-33 and thymic stromal lymphopoietin are primary cytokines involved in the Th1/Th2 inflammatory response in chronic secretory otitis media

et al. 2022

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Background: T-helper (Th)1/Th2 inflammatory responses are responsible for secretory otitis media (SOM) development. However, the mechanisms underlying these immune responses remain unknown. This study aims to identify the primary cytokines that play essential roles in chronic SOM. Methods: Two groups were established for the present study: chronic SOM group ( n = 21) and control group ( n = 10). The middle ear effusion and serum samples of the expression cytokines (interleukin IL-2, IL-4, IL-5, IL-13, IL-17, IL-25, IL-33, interferon [IFN]-γ, thymic stromal lymphopoietin [TSLP], immunoglobulin IgE, and pepsins) were analyzed by enzyme-linked immunosorbent assay. Results: The levels of IL-4, IL-5, IL-13, IL-17, IL-25, IFN-γ, TLSP, pepsins, IL-2, and IL-33 (all, p < 0.001) were higher in middle ear effusion, when compared to those in serum, in chronic SOM group (non-paired sample). However, there was no significant difference in serum expression for those cytokines compared chronic SOM group and control group. The paired sample expression for IL-33 and TLSP (both, p = 0.046) were higher compared the effusion and serum in chronic SOM group. Conclusions: IL-33 produces inflammatory cytokines, such as IL-1b, IL-6, TNF-α, IL-10, IL-4, and TGF-β, which through nucleus into cytoplasm causing inflammatory responses. The present study revealed that IL-33 also produce IL-17, IL-4, IL-5, and IL-13 inflammatory factors, triggering an inflammatory response. Study reported that the combined stimulation of TSLP and IL-33 elicits an approximately 10-fold increase in cytokine production, when compared to the stimulation of IL-33 alone. This suggests that IL-33 and TLSP may be the primary cytokines involved in Th1/Th2 inflammatory responses in chronic SOM.

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Section: Discussionsupporting

confidence: 81%

Interleukin-33 and thymic stromal lymphopoietin are primary cytokines involved in the Th1/Th2 inflammatory response in chronic secretory otitis media

et al. 2022

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“…In recent years, emphasis has been placed on strategies encompassing observation versus antimicrobial therapy, the appropriate choice of antibiotics, prevention of deleterious sequelae, and improvement of analgesia . Further inquiry will likely build on these issues and others, including indications for operative intervention, how best to deal with rising microbial resistance patterns, and previously noted associations with other conditions such as reflux . Otolaryngologists play a crucial part in treating complicated OM by deciding the appropriate time to perform surgery and managing such patients for many years.…”

Section: Introductionmentioning

confidence: 99%

Scholarly investigation into otitis media: who is receiving funding support from the National Institutes of Health?

et al. 2015

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The NIH provided considerable grant support for researchers studying OM as awards to practitioners in numerous specialties exceeded a quarter of a billion dollars since 2000. Although awards to otolaryngologists were significant, the share of grants awarded to otolaryngologists has declined, suggesting that increased recruitment of basic scientists and enhanced cooperation with other specialists may facilitate further scholarship. These findings suggest a need for improving initiatives that prepare otolaryngology trainees interested in translational OM research for the rigorous NIH peer-review grant process.

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“…As regard food allergy history, it was e positive in 10.2% of studied children and this agrees with Döner et al [21] who found a higher prevalence of food allergy in OME patients than in controls. Collection of MEE samples was collected by many methods Gomaa et al [1] and El-Sharnoby et al [22] obtained effusion fluid samples from patients by using wide bore (5 ml.) syringe in their clinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…Otitis media with effusion (OME) is defined as chronic inflammation of the middle ear mucosa characterized by fluid storage behind an intact tympanic membrane (TM) within the middle ear space without signs or symptoms of an acute ear infection [1]. It is one of the most common causes of childhood hearing loss that leads to surgical intervention [2].…”

Section: Introductionmentioning

confidence: 99%

May allergy have a role in primary or recurrent otitis media in Egyptian pediatric patients: a prospective study

El-Shahat

Elsharkawy

Shahin

et al. 2021

Egyptian Journal of Basic and Applied Sciences

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This study aimed to estimate the levels of total serum IgE and assess the presence of eosinophils in middle ear fluid in primary and recurrent otitis media with effusion in Egyptian pediatric patients. A prospective study of 59 children with bilateral otititis media effusion (OME) were enrolled in this study. All patients had refractory OME to non-surgical lines of treatment. Full history was taken then detailed ENT examination followed by various investigations in the form of pure tone audiometry, tympanometry, serum total IgE, and eosinophilia. The incidence of allergic dermatitis, food allergy, allergic conjunctivitis, and anaphylaxis were (64.4%), (32.2%), (33.9%), (10.2%), (8.5%), and (5.1%), respectively. In this study middle ear effusion, eosinophils were positive in (61%). Total IgE was high in 40 children (67.8%). There was a strong relationship of recurrent OME with allergic manifestations, serum IgE, middle ear effusion fluid eosinophils, and blood eosinophilia suggesting intimately important role of allergy in the recurrence of OME. Allergy has a fundamental role in the pathogenesis of recurrent OME. The possibility of allergy should be considered in OME cases that did not improve with conventional lines of treatment.

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Role of immunoglobulin E and gastro-esophageal reflux disease in the development of otitis media with effusion

Abstract: Allergy is a possible risk factor for the development of OME. The level of PG1in the effusion is one tenth of its level in the serum of the patients.

Cited by 5 publications

References 23 publications

Interleukin-33 and thymic stromal lymphopoietin are primary cytokines involved in the Th1/Th2 inflammatory response in chronic secretory otitis media

Interleukin-33 and thymic stromal lymphopoietin are primary cytokines involved in the Th1/Th2 inflammatory response in chronic secretory otitis media

Scholarly investigation into otitis media: who is receiving funding support from the National Institutes of Health?

May allergy have a role in primary or recurrent otitis media in Egyptian pediatric patients: a prospective study

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