Role of immune cells in crystal-induced kidney fibrosis

Dhana, Ermanila; Ludwig‐Portugall, Isis; Kurts, Christian

doi:10.1016/j.matbio.2017.11.013

Cited by 8 publications

(8 citation statements)

References 106 publications

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“…When barrier is ruptured "leaky gut, " immune cells are activated, infiltrate the kidney, and induce proinflammatory and anti-inflammatory functions, as well as regulatory signals to modulate the neutrophil response (39). Neutrophils and macrophages are implicated in the innate immunity as first-line response of non-specific defense against pathogens (40).…”

Section: Metabolic and Immune Pathways Involved In Kidney Diseasesmentioning

confidence: 99%

Focus on the Gut–Kidney Axis in Health and Disease

et al. 2021

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The recent new developments in technology with culture-independent techniques including genome sequencing methodologies shed light on the identification of microbiota bacterial species and their role in health and disease. Microbiome is actually reported as an important predictive tool for evaluating characteristic shifts in case of disease. Our present review states the development of different renal diseases and pathologies linked to the intestinal dysbiosis, which impacts on host homeostasis. The gastrointestinal–kidney dialogue provides intriguing features in the pathogenesis of several renal diseases. Without any doubt, investigation of this interconnection consists one of the most cutting-edge areas of research with potential implications on our health.

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Section: Metabolic and Immune Pathways Involved In Kidney Diseasesmentioning

confidence: 99%

Focus on the Gut–Kidney Axis in Health and Disease

et al. 2021

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“…Their role in promoting TIF is unclear as their deletion (CD11c/DTR) did not alter matrix accumulation in the UUO model[38, 39]. The role of DCs may also depend upon the etiology of injury as these cells have been shown to activate the inflammasome leading to renal fibrosis in crystal induced nephropathies[40].…”

Section: Introductionmentioning

confidence: 99%

Renal fibrosis: Primacy of the proximal tubule

2018

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Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of renal survival. Many different cell types contribute to TIF progression including tubular epithelial cells, myofibroblasts, endothelia, and inflammatory cells. Previously, most of the attention has centered on myofibroblasts given their central importance in extracellular matrix production. However, emerging data focuses on how the response of the proximal tubule, a specialized epithelial segment vulnerable to injury, plays a central role in TIF progression. Several proximal tubular responses such as de-differentiation, cell cycle changes, autophagy, and metabolic changes may be adaptive initially, but can lead to maladaptive responses that promote TIF both through autocrine and paracrine effects. This review discusses the current paradigm of TIF progression and the increasingly important role of the proximal tubule in promoting TIF both in tubulointerstitial and glomerular injuries. A better understanding and appreciation of the role of the proximal tubule in TIF has important implications for therapeutic strategies to halt chronic kidney disease progression.

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“…However, when the intestinal barrier is breached, a situation called “leaky gut,” the gut bacteria and their toxins are able to infiltrate the intestinal mucosa and then through the blood stream circulate to different tissues and organs ( 1 , 29 ). Moreover, activated immune cells penetrate the kidney and generate pro-and anti-inflammatory reactions and regulatory signals in order to induce a neutrophils response ( 30 ). Neutrophils together with macrophages are induced as part of the first line response in innate immunity against pathogens ( 31 ) and kidney disease ( 32 ).…”

Section: Immunological Pathways In Kidney Diseasementioning

confidence: 99%

“…Renal tubular epithelial cells present a crucial role in inflammation, positively or negatively regulating T cell responses in an alternative way, as they express co-stimulators of T cells (ICOS-L) and B7-H1 molecules ( 43 ). Yet, macrophages, dendritic cells (DCs), and T regulatory cells (Tregs) induce an adaptive immune response and DC activation promotes the production of proinflammatory cytokines such as IL-12 and IL-6 ( 30 ). Clearly, DCs trigger the differentiation of naïve CD4 + T cells into regulatory T (Treg) cells and the maturation of B cells into IgA-secreting ones ( 30 , 44 ).…”

Section: Immunological Pathways In Kidney Diseasementioning

confidence: 99%

“…Yet, macrophages, dendritic cells (DCs), and T regulatory cells (Tregs) induce an adaptive immune response and DC activation promotes the production of proinflammatory cytokines such as IL-12 and IL-6 ( 30 ). Clearly, DCs trigger the differentiation of naïve CD4 + T cells into regulatory T (Treg) cells and the maturation of B cells into IgA-secreting ones ( 30 , 44 ). The role of Treg cells in renal disease seems to be crucial in protecting against inflammation processes and amplifying homeostasis by boosting microbiota ( 45 ).…”

Section: Immunological Pathways In Kidney Diseasementioning

confidence: 99%

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Microbiome, Immunosenescence, and Chronic Kidney Disease

et al. 2021

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The gut microbiome is known as an important predictive tool for perceiving characteristic shifts in disease states. Multiple renal diseases and pathologies seem to be associated with gut dysbiosis which directly affects host homeostasis. The gastrointestinal-kidney dialogue confers interesting information about the pathogenesis of multiple kidney diseases. Moreover, aging is followed by specific shifts in the human microbiome, and gradual elimination of physiological functions predisposes the microbiome to inflammaging, sarcopenia, and disease. Aging is characterized by a microbiota with an abundance of disease-associated pathobionts. Multiple factors such as the immune system, environment, medication, diet, and genetic endowment are involved in determining the age of the microbiome in health and disease. Our present review promotes recently acquired knowledge and is expected to inspire researchers to advance studies and investigations on the involved pathways of the gut microbiota and kidney axis.

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Role of immune cells in crystal-induced kidney fibrosis

Cited by 8 publications

References 106 publications

Focus on the Gut–Kidney Axis in Health and Disease

Focus on the Gut–Kidney Axis in Health and Disease

Renal fibrosis: Primacy of the proximal tubule

Microbiome, Immunosenescence, and Chronic Kidney Disease

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