Role of immune cells in the ocular manifestations of pemphigoid diseases

Abstract

Pemphigoid disease is classified according to the phenotypical location of the disease and the presence of different types of antibodies. The ocular distribution of pemphigoid mainly occurs in patients with bullous pemphigoid and mucous membrane pemphigoid. Several immune cells, including the cells of the innate immune system (neutrophils and γδ T cells) and the adaptive immune system (T and B cells), are involved in pemphigoid disease. The treatment of pemphigoid is still wide-ranging, and the most utilized treatment is the use of immunosuppressants and corticosteroids. In this scenario, it is absolutely important to screen the immune cells that are involved in this group of diseases and to determine if a targeted treatment approach is plausible. In conclusion, this review will identify some newer treatment possibilities for the whole spectrum of pemphigoid diseases.

Ocular Cicatricial Pemphigoid Activation After COVID-19 Infection

“…Although the resulting xerosis is severe, it is associated with limbal stem cell damage and progressive subepithelial fibrosis leading to ocular keratinization. 3 Our patient had severe dry eye in both eyes. While there was 360⁰ limbal insufficiency and secondary total corneal neovascularization in his right eye, there was limbal insufficiency in the 60⁰ area in his left eye and corneal neovascularization in the area corresponding to this region.…”

“…The disease typically lasts for several years and can ultimately lead to blindness without treatment. [1][2][3][4][5] It has been reported that coronavirus disease-2019 (COVID-19) infection stimulated the immune system and caused the activation of autoimmune diseases. 6 We aimed to present a patient who had reactivation of OCP in the right eye and new diagnosis of OCP in the left eye, after COVID-19 infection.…”