Role of imaging in the evaluation of inflammatory bowel disease: How much is too much?

Haas, Kelly; Rubesova, Erika; Bass, Dorsey

doi:10.4329/wjr.v8.i2.124

Cited by 27 publications

(28 citation statements)

References 58 publications

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“…[2][3][4][5][6][7] This issue emphasizes the importance of a noninvasive and accurate diagnostic method in clinical practice. 3,8,9 None of the imaging modalities alone could qualify as gold standard for evaluation of all of the aspects of UC. [9][10][11] Ultrasonography in comparison with endoscopy is noninvasive, inexpensive, radiation free, easy to use, acceptable, repeatable and completely compatible with an ideal diagnostic method.…”

Section: Introductionmentioning

confidence: 99%

“…3,8,9 None of the imaging modalities alone could qualify as gold standard for evaluation of all of the aspects of UC. [9][10][11] Ultrasonography in comparison with endoscopy is noninvasive, inexpensive, radiation free, easy to use, acceptable, repeatable and completely compatible with an ideal diagnostic method. 12 Tran abdominal ultrasonography is useful for diagnosing of bowel wall thickness, the extent of inflammatory involvement and assessment of disease activity.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of ultrasonography in comparison with colonoscopy for diagnosing of ulcerative colitis

Alavinejad¹,

Hajiani²,

Gharibvand³

et al. 2018

GHOA

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Aim: To evaluate diagnostic accuracy of ultrasonography in comparison with colonoscopy as gold standard for diagnosing of ulcerative colitis (UC). Method: In this prospective study, 114 participants who attended in Ahvaz Imam Hospital during March 2014 to February 2015 included. The participants divided into 2 groups: group A as 64 UC patients (flare or new case) and 50 participants as control group who attend for colorectal cancer screening or evaluation of rectorrhagia. All of the participants obtained a Trans abdominal ultrasonography after 8hours fasting and evaluated for colonic thickness in any involved region, loss of compressibility, peristaltic movement, mesenteric lymph nodes enlargement and presence or absence of ascites, fat stranding or stratification. Results: Ultrasonography sensitivity for diagnosing of moderate to severe UC in comparison with colonoscopy was between 52.56 to 86.36% based on different factors such as new onset or active disease, BMI, gender and region of involvement. In all of the situations the specificity was 100%. The sensitivity for diagnosing new cases of UC and pancolitis were 86.36% and 76.67% respectively and these figures were less among cases with BMI more than 25. The colonic wall thickness in new cases of UC (6.4±1.3mm) was significantly more than wall thickness among disease flare up (5.5±1.7mm) (P=0.02) and also average colon thickness in UC group (average 5.9mm , range 2-9mm) was significantly more than control group (average 3.3mm, range 3-4mm). Conclusion: The findings of current study prove that ultrasonography is not an ideal tool for evaluation of UC patients because its results could affect by several factors such as BMI and region of involvement.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of ultrasonography in comparison with colonoscopy for diagnosing of ulcerative colitis

Alavinejad¹,

Hajiani²,

Gharibvand³

et al. 2018

GHOA

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“…The machines used for sonographic evaluation of the gastrointestinal tract are no different than those used in standard radiology units. Nevertheless, the performance of intestinal ultrasound is dedicated to experienced sonographers, who are able to recognise and evaluate all bowel structures and their abnormalities [ 6 , 10 ]. The performance of bowel ultrasound involves the use of two different probes: low-frequency convex probe (3.0–3.5 MHz) and high-frequency linear probe (5–17 MHz) [ 11 ].…”

Section: Ultrasound Techniquesmentioning

confidence: 99%

“…Over the past few years, thanks to technological progress in ultrasonography, followed by increasing experience of physicians, intestinal ultrasound has become an important diagnostic tool in the detection of bowel diseases. Being a safe, fast, inexpensive imaging method with high sensitivity and specificity, it is commonly used in European countries, such as Italy and Germany, especially for the diagnosis and monitoring of inflammatory bowel diseases (IBD) [ 1 – 6 ]. The performance of the intestinal ultrasound can be improved by the use of intraluminal or intravenous contrast media [ 4 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The role of intestinal ultrasound in diagnostics of bowel diseases

Andrzejewska

Grzymisławski

2018

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Intestinal ultrasound is a safe and inexpensive method that allows visualisation of the gastrointestinal tract and detection of abnormalities. This examination involves the use of two different ultrasound transducers: a low-frequency convex probe and high-frequency linear probe. When needed, the performance of these methods can be enhanced by the use of contrast media or Doppler techniques. Intestinal ultrasound is mostly utilised for the diagnosis and follow-up of patients with inflammatory bowel diseases, helping to avoid frequent use of invasive and expensive diagnostic procedures and leading to early implementation of suitable treatment. This technique can also serve to detect other pathologic conditions that are present in the gastrointestinal tract. It is a promising method with high sensitivity and specificity, which has gained popularity in recent years and has the potential to become the method of choice in the diagnostics of many intestinal disorders.

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“…Whilst computed tomography (CT) is a widely available and fast method, it lacks sensitivity in terms of detection of early mucosal changes, and is associated with the risks of repeated radiation exposure. Due to the technical progress of the last years, magnetic resonance imaging (MRI) has become the imaging modality of choice in detection, surveillance, therapy monitoring and evaluation of the extent of IBDs in humans [ 13 , 14 ]. However, bowel imaging in animal models remains challenging.…”

Section: Introductionmentioning

confidence: 99%

Application of machine learning algorithms for multiparametric MRI-based evaluation of murine colitis

Ellmann

Langer²,

Britzen-Laurent³

et al. 2018

PLoS ONE

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Magnetic resonance imaging (MRI) allows non-invasive evaluation of inflammatory bowel disease (IBD) by assessing pathologically altered gut. Besides morphological changes, relaxation times and diffusion capacity of involved bowel segments can be obtained by MRI. The aim of this study was to assess the use of multiparametric MRI in the diagnosis of experimentally induced colitis in mice, and evaluate the diagnostic benefit of parameter combinations using machine learning. This study relied on colitis induction by Dextran Sodium Sulfate (DSS) and investigated the colon of mice in vivo as well as ex vivo. Receiver Operating Characteristics were used to calculate sensitivity, specificity, positive- and negative-predictive values (PPV and NPV) of these single values in detecting DSS-treatment as a reference condition. A Model Averaged Neural Network (avNNet) was trained on the multiparametric combination of the measured values, and its predictive capacity was compared to those of the single parameters using exact binomial tests. Within the in vivo subgroup (n = 19), the avNNet featured a sensitivity of 91.3% (95% CI: 86.6–96.0%), specificity of 92.3% (95% CI: 85.1–99.6%), PPV of 96.9% (94.0–99.9%) and NPV of 80.0% (95% CI: 69.9–90.1%), significantly outperforming all single parameters in at least 2 accuracy measures (p < 0.003) and performing significantly worse compared to none of the single values. Within the ex vivo subgroup (n = 30), the avNNet featured a sensitivity of 87.4% (95% CI: 82.6–92.2%), specificity of 82.9% (95% CI: 76.1–89.7%), PPV of 88.9% (84.3–93.5%) and NPV of 80.8% (95% CI: 73.8–87.9%), significantly outperforming all single parameters in at least 2 accuracy measures (p < 0.015), exceeded by none of the single parameters. In experimental mouse colitis, multiparametric MRI and the combination of several single measured values to an avNNet can significantly increase diagnostic accuracy compared to the single parameters alone. This pilot study will provide new avenues for the development of an MR-derived colitis score for optimized diagnosis and surveillance of inflammatory bowel disease.

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Role of imaging in the evaluation of inflammatory bowel disease: How much is too much?

Cited by 27 publications

References 58 publications

Diagnostic accuracy of ultrasonography in comparison with colonoscopy for diagnosing of ulcerative colitis

Diagnostic accuracy of ultrasonography in comparison with colonoscopy for diagnosing of ulcerative colitis

The role of intestinal ultrasound in diagnostics of bowel diseases

Application of machine learning algorithms for multiparametric MRI-based evaluation of murine colitis

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