Role of illness in producing learned taste aversions in rats: A comparison of several rodenticides.

Abstract

Several toxic agents were compared in order to test the effect of various types of illness in producing learned taste aversions. After a 10-min sucrose drinking trial, groups of rats were injected intraperitoneally with lithium chloride or with a strong, near lethal dose of a rodenticide. Strong sucrose aversions were acquired by groups injected withlithium chloride, coppersulfate, sodium fluoroacetate, or red squill, and very weak or no aversions were learned by groups injected with thallium, warfarin, cyanide, or strychnine. The results were discussed in terms of onset of symptoms, duration of symptoms, and kinds of physiological effects necessary to produce aversions. It was concluded that the effects of different drugs may be mediated by different physiological systems in producing learned taste aversions.

Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences

“…However, the neophobic behaviour of some rodents such as rats and their social organisation make these molecules inefective. Indeed, the precocity of symptoms or death after a bait eating by congeners induces bait aversion in the rodent population [28,29]. Conversely, the time to onset of anticoagulant action is suicient to avoid that rodents link their symptoms and death to bait eating [29].…”

Role of the area postrema in three putative measures of motion sickness in the rat

“…One likely candidate is the vagus, since any internal aversive state produced in the rat by rotational stimulation could be acting through peripheral gastrointestinal mechanisms, much like intragastric copper sulfate. This peripherally acting emetic produces strong CTA in the rat (Nachman & Hartley, 1975), produces emesis in animals with lesions of the AP (Borison & Wang, 1953), but is ineffective for producing CTA in vagotomized rats when given orally or intragastrically (Coil et al, 1978;Rauschenberger, 1979). However, although a study on motioninduced CTA in vagotomized rats would be informative, even if such intervention prevents acquisition of motion-induced CTA any analogy with "motion sickness"…”

Conditioned taste aversion in Philippine rice rats (R. r. mindanensis): Comparisons among drugs, dosages, modes of administration, and sexes

“…CTA effects of various rodenticides have been compared with LiCI-induced aversion, and the CTA effects of route of drug administration have been examined using albino rats and short-term tests of aversion (Nachman & Ashe, 1973;Nachman & Hartley, 1975). The current studies sought to investigate the effects of select drugs, dosages, and modes of drug administration upon long-term saccharin aversions of a species of wild rodent (i.e., Rattus rattusmindanensisi.…”