Role of IL-35 in sublingual allergen immunotherapy

Shamji, Mohamed H.; Layhadi, Janice A.; Achkova, Daniela; Kouser, Lubna; Perera-Webb, Alan; Couto-Francisco, Natália C.; Parkin, Rebecca; Matsuoka, Tomokazu; Scadding, Guy W.; Ashton‐Rickardt, Philip G.; Durham, Stephen R.

doi:10.1016/j.jaci.2018.06.041

Cited by 89 publications

(84 citation statements)

References 50 publications

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“…[34][35][36] Furthermore, it induces the production of IL-10 and IFN-γ. 37 In addition to IL-35, an increase in IFN-γ and IL-10 has been observed in Trichuris muris-infected mice, and this increase can inhibit the allergic airway inflammation induced by papain. 38 Although we did not investigate how IFN-γ, IL-10 and IL-35 affect and produce one another by SJMHE1 treatment, we found that the inhibition of IL-4, IL-5 and IL-17 and elevation of IFN-γ, IL-10 and IL-35 may contribute to the protection conferred by SJMHE1 in allergic mice.…”

Section: Discussionmentioning

confidence: 99%

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice

Zhang

Zheng

et al. 2019

J Cellular Molecular Medi

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Helminths and their products can shape immune responses by modulating immune cells, which are dysfunctional in inflammatory diseases such as asthma. We previously identified SJMHE1, a small molecule peptide from the HSP60 protein of Schistosoma japonicum. SJMHE1 can inhibit delayed‐type hypersensitivity and collagen‐induced arthritis in mice. In the present study, we evaluated this peptide's potential intervention effect and mechanism on ovalbumin‐induced asthma in mice. SJMHE1 treatment suppressed airway inflammation in allergic mice, decreased the infiltrating inflammatory cells in the lungs and bronchoalveolar lavage fluid, modulated the production of pro‐inflammatory and anti‐inflammatory cytokines in the splenocytes and lungs of allergic mice, reduced the percentage of Th2 cells and increased the proportion of Th1 and regulatory T cells (Tregs). At the same time, Foxp3 and T‐bet expression increased, and GATA3 and RORγt decreased in the lungs of allergic mice. We proved that SJMHE1 can interrupt the development of asthma by diminishing airway inflammation in mice. The down‐regulation of Th2 response and the up‐regulation of Th1 and Tregs response may contribute to the protection induced by SJMHE1 in allergic mice. SJMHE1 can serve as a novel therapy for asthma and other allergic or inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice

Zhang

Zheng

et al. 2019

J Cellular Molecular Medi

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“…Our results found that baseline Th2 (IL-4, IL-5, and IL-13) and Th17 (IL-17) cytokines had no correlation with short-term efficacy, suggesting that Th1/Th2 imbalance was not reversed in the short term. Multivariate logistic 3 [15,16]. Therefore, it is reasonable that higher baseline levels of IL-10 and IL-35 may predict good response of SLIT.…”

Section: Discussionmentioning

confidence: 99%

Predictors for Short-Term Efficacy of Allergen-Specific Sublingual Immunotherapy in Children with Allergic Rhinitis

Liu

Zeng

Luo

2020

Mediators of Inflammation

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Background.A good compliance in allergen-specific sublingual immunotherapy (SLIT) often comes from good short-term efficacy. We aimed to evaluate the pretreatment parameters which can predict the short-term clinical efficacy in children that underwent SLIT. Methods. 517 children with allergic rhinitis (AR) that underwent SLIT were recruited in this study. Baseline clinical characteristics and laboratory parameters were collected, and the clinical efficacy was evaluated using symptom and medication scores. A multivariate logistic regression model and receiver operating characteristic (ROC) curves were established. Results. A total of 303 (65%) in 466 children that underwent SLIT achieved short-term clinical efficacy. The time of using the air conditioner was negatively correlated with clinical efficacy, whereas the serum-specific IgE (s-IgE) levels, the serum IL-10 and IL-35 levels, and the s-IgE/total-IgE ratio were positively correlated with clinical efficacy. Conclusion. The time of using the air conditioner, serum-specific IgE (s-IgE) levels, serum IL-10 and IL-35 levels, and s-IgE/total-IgE ratio may be helpful for child selection before SLIT.

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“…Accordingly, IL-35 has recently been shown to suppress grass pollenspecific Th2 cell responses in cells from SAR patients and to suppress production of IL-5 and IL-13 by ILC2s from these individuals. 159 Moreover, IL-35 + Tregs were less frequent in peripheral blood of SAR patients, but were elevated with sublingual allergen immunotherapy, inversely correlating with symptom scores. 159 Although these studies used peripheral blood cells as a surrogate for those from tissue, they suggest a role for IL-35 in regulating the type 2 immune response to grass pollen in the upper airways.…”

Section: Il-35 Suppression Of Allergic Airway Diseasementioning

confidence: 96%

“…155 IL-35 REGULATION OF IMMUNITY IL-35, but not IL-12α or EBI3 alone, suppresses Teff proliferation in vitro 149 and suppresses Th17 cell generation in vitro and during Regulatory cytokine function in the respiratory tract WJ Branchett and CM Lloyd experimental arthritis in vivo. 157 IL-35 can also drive differentiation of an IL-35 + CD4 + Treg population, termed iTr35 cells, 158,159 when signaling via the IL-12Rβ2-gp130 heterodimer. 155 A population of FoxP3 + IL-35 + Tregs exists in secondary lymphoid organs at steady state 160 and can expand in the gut during helminth infection.…”

Section: Il-35 Signalingmentioning

confidence: 99%

Regulatory cytokine function in the respiratory tract

Branchett

Lloyd

2019

Mucosal Immunology

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The respiratory tract is an important site of immune regulation; required to allow protective immunity against pathogens, while minimizing tissue damage and avoiding aberrant inflammatory responses to inhaled allergens. Several cell types work in concert to control pulmonary immune responses and maintain tolerance in the respiratory tract, including regulatory and effector T cells, airway and interstitial macrophages, dendritic cells and the airway epithelium. The cytokines transforming growth factor β, interleukin (IL-) 10, IL-27, and IL-35 are key coordinators of immune regulation in tissues such as the lung. Here, we discuss the role of these cytokines during respiratory infection and allergic airway disease, highlighting the critical importance of cellular source and immunological context for the effects of these cytokines in vivo.

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Role of IL-35 in sublingual allergen immunotherapy

Abstract: IL-35 and iT35 cells are potential novel immune regulators induced by SLIT. The clinical relevance of SLIT can be underscored by restoration of protective iT35 cells.

Cited by 89 publications

References 50 publications

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice

Predictors for Short-Term Efficacy of Allergen-Specific Sublingual Immunotherapy in Children with Allergic Rhinitis

Regulatory cytokine function in the respiratory tract

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