Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps

Ouyang, Hong; Cheng, Jie; Zheng, Yajun; Du, Jingdong

doi:10.1007/s00405-014-2913-x

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…The expression of IL-31 is elevated in NPs and IL-31 protein levels correlated with clinical outcome, probably due to the IL-31-amplified T H 2-skewed inflammation profile. 82 Expression levels of IL-31 and IL31RA were further found upregulated in the inferior turbinate of patients with allergic rhinitis. 91 IL31RA primarily localized to submucosal glands and stimulation of A549 cells induced expression of themucin 5AC (MUC5AC ) gene suggesting a role for IL-31 in mucus overproduction during nasal allergic inflammation.…”

Section: Il-31 In Mucosal Airway and Intestinementioning

confidence: 95%

“…Recently, IL-31 signaling has been detected in mucosal sites of the human lung, nasal sinus and intestine (Figure 3). [81][82][83] Lung epithelial cells express IL31RA, OSMRβ and gp130. Although both, OSM and IL-31, engage with equal affinities to IL31RA/OSMRβ of lung epithelium and activate common signal transduction pathways, each agonist can activate distinct downstream signaling cascades.…”

Section: Il-31 In Mucosal Airway and Intestinementioning

confidence: 99%

“…IL-31 has recently been implicated in the pathogenesis of nasal polyps (NP) of the sinus mucosa. 82 Nasal polyps are similar to AD histologically characterized by an infiltration of lymphocytes, especially T H 2 cells, and eosinophils, considered now as a type-2 inflammation. The expression of IL-31 is elevated in NPs and IL-31 protein levels correlated with clinical outcome, probably due to the IL-31-amplified T H 2-skewed inflammation profile.…”

Section: Il-31 In Mucosal Airway and Intestinementioning

confidence: 99%

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Interleukin-31: The ‘itchy’ cytokine in inflammation and therapy

Datsi¹,

Alam²,

Faried³

et al. 2020

Preprint

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Interleukin-31 has been implicated in the pathophysiology of multiple atopic disorders such as atopic dermatitis (AD), rhinitis and airway hyperreactivity. In AD, IL-31 has been identified as one of the main ‘drivers’ of its cardinal symptom pruritus. Here, we aim to summarize the mechanisms by which IL-31 modulates inflammatory and allergic diseases. TH2 cells play a central role in AD and release high levels of TH2-produced cytokines including IL-31, thereby mediating inflammatory responses, initiating immunoregulatory circuits, and stimulating itch and neuronal outgrowth through activation of the heterodimer receptor IL-31 receptor alpha (IL31RA)/Oncostatin M receptor β. IL31RA expression is found on human and murine dorsal root ganglia neurons, epithelial cells including keratinocytes as well as various innate immune cells. IL-31 is a critical cytokine involved in neuro-immune communication, which opens new avenues for cytokine modulation in neuroinflammatory diseases including AD/pruritus, as validated by recent clinical trials using an anti-IL-31 antibody. Accordingly, inhibition of IL-31 downstream signaling may be a beneficial approach for various inflammatory diseases including prurigo nodularis. For example, whether downstream JAK inhibitors directly block IL-31-mediated-signaling needs to be clarified. Targeting the IL-31/IL31RA/OSMRβ axis appears to be a promising approach for inflammatory, neuroinflammatory and pruritic disorders in the future.

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Section: Il-31 In Mucosal Airway and Intestinementioning

confidence: 95%

Section: Il-31 In Mucosal Airway and Intestinementioning

confidence: 99%

Section: Il-31 In Mucosal Airway and Intestinementioning

confidence: 99%

See 1 more Smart Citation

Interleukin-31: The ‘itchy’ cytokine in inflammation and therapy

Datsi¹,

Alam²,

Faried³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…It acts through the oncostatin receptor (OSMR) and heterodimeric receptors of IL-31 (IL-31R), a complex that stimulates the JAK-STAT, the phosphoinositol 3-kinase (PI3K)/AKT, and the RAS/extracellular signal-regulated kinase (ERK) signal pathways (7,8). There is emerging evidence showing that the IL-31/IL-31R signaling pathway plays an important role in the pathogenesis of atopic and allergic diseases and inflammatory diseases such as allergic contact dermatitis (9,10), nonatopic eczema (11), spontaneous urticaria (12), nasal polyps (13), asthma (14), and familial primary cutaneous amyloidosis (15). Nevertheless, there is a paucity of data exploring the potential role of IL-31 in the pathogenesis of ACLF.…”

mentioning

confidence: 99%

The Transforming Growth Factor β1/Interleukin-31 Pathway Is Upregulated in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure and Is Associated with Disease Severity and Survival

Guo

Ming

et al. 2015

Clin. Vaccine Immunol.

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The transforming growth factor ␤1/interleukin-31 (TGF-␤1/IL-31) pathway plays an important role in the process of cell injury and inflammation. The purpose of this work was to explore the role of the TGF-␤1/IL-31 pathway in the cytopathic process of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF). The quantitative serum levels of TGF-␤1, IL-9, IL-10, IL-17, IL-22, IL-23, IL-31, IL-33, and IL-35 were analyzed among chronic hepatitis B (CHB) patients (n ‫؍‬ 17), ACLF patients (n ‫؍‬ 18), and normal control (NC) subjects (n ‫؍‬ 18). Disease severity in patients with ACLF was assessed using the model for endstage liver disease (MELD) and Child-Pugh scores. Serum TGF-␤1 levels were strongly positively correlated with IL-31 in all subjects, and both of them were positively correlated with IL-17, IL-22, and IL-33. In CHB and ACLF patients, serum levels of TGF-␤1 and IL-31 were both increased significantly compared with those in NC subjects and positively correlated with total bilirubin (TBil) and alpha-fetoprotein (AFP) levels. ACLF patients showed the highest levels of TGF-␤1 and IL-31, which were positively correlated with Child-Pugh scores. Furthermore, the recovery from the liver injury in CHB was accompanied by decreased TGF-␤1 and IL-31 levels. More importantly, serum levels of TGF-␤1 and IL-31 were markedly upregulated in ACLF nonsurvivors, and IL-31 displayed the highest sensitivity and specificity (85.7% and 100.0%, respectively) in predicting nonsurvival of ACLF patients. Increasing activity of the TGF-␤1/IL-31 pathway is well correlated with the extent of liver injury, disease severity, and nonsurvival of ACLF patients, while reducing activity is detected along the recovery from liver injury in CHB, suggesting its potential role in the pathogenesis of liver injury during chronic HBV infection. Hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) is triggered mainly by severe extensive liver injury, and the exact mechanisms of massive destruction of HBV-infected hepatocytes remain unclear. However, one of the current assumptions is that the imbalance of the cytokine network, the so-called cytokine storm theory (1), points to potential involvement of inflammatory cytokines in destroying the HBV-infected cells, which may provide an explanation for the aggravation of liver injury.Transforming growth factor-␤1 (TGF-␤1) is a 25-kDa homodimeric protein composed of two subunits linked by a disulfide bond and is a powerful inhibitor of DNA synthesis and cellular proliferation (2). It also mediates formation of extracellular matrix and facilitates cell differentiation (3). Previous studies have shown that TGF-␤1 plays a role in developing liver failure (LF). Miwa et al. found that the mRNA and protein expression of TGF-␤1 were significantly upregulated in both the plasma and liver tissue in patients with fulminant liver failure (FLF) (4). Yoshimoto et al. found that the overexpression of TGF-␤1 delayed liver regeneration and promoted perisinusoidal fibrosis and hepatocyte apoptos...

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“…Interleukin (IL)-31 is a cytokine that was recently identified by Dillon and colleagues 3 . IL-31 has been confirmed to be involved in the pathogenesis of inflammatory diseases such as atopic dermatitis, itching, alopecia, inflammatory bowel disease, airway hypersensitivity and hepatitis B related liver failure 4 5 6 7 8 . Tuberculous pleurisy is the most common extrapulmonary tuberculosis clinically 9 .…”

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confidence: 99%

Potential diagnostic value of serum/pleural fluid IL-31 levels for tuberculous pleural effusion

Gao

et al. 2016

Sci Rep

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The aim of this study was to explore the diagnostic value of IL-31 levels in the pleural fluid and plasma to differentially diagnose tuberculous and malignant pleural effusion. We enrolled 91 cases, including tuberculous pleural effusion (TPE, n = 50), malignant pleural effusion (MPE, n = 41), other cases including pneumonia with pleural fluid, pulmonary tuberculosis and healthy people as controls. Whole blood was stimulated with the M. tuberculosis–specific antigens and plasma was collected. The multiplex bead-based cytokine immunoassay was employed to measure the levels of various cytokines. IL-31 was found to be the most prominent cytokine (P < 0.0001), and with an optimal cut-off value of 67.5 pg/mL, the sensitivity and specificity for the diagnosis of TPE were 86% and 100%, respectively. Furthermore, the tuberculosis-specific IL-31 levels in the plasma of TPE patients were higher than that of MPE patients (P = 0.0002). At an optimal cut-off value of 23.9 pg/mL, the sensitivity and specificity for the diagnosis of TPE were 92.9% and 85.7%, respectively. Ultimately, the combination of pleural fluid with the plasma tuberculosis-specific IL-31 levels improved the sensitivity and specificity to 94.0% and 95.1%, respectively. Thus, we identified a novel biomarker for the diagnosis of TPE for clinical application.

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Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps

Cited by 9 publications

References 23 publications

Interleukin-31: The ‘itchy’ cytokine in inflammation and therapy

Interleukin-31: The ‘itchy’ cytokine in inflammation and therapy

The Transforming Growth Factor β1/Interleukin-31 Pathway Is Upregulated in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure and Is Associated with Disease Severity and Survival

Potential diagnostic value of serum/pleural fluid IL-31 levels for tuberculous pleural effusion

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