Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis

Hasan, Simon A.; Eksteen, Bertus; Reid, Danielle; Paine, Heather V.; Alansary, Abrar; Johannson, Kerri A.; Gwozd, Carol; Goring, Kimberly-Ann R.; Vo, Tina; Proud, David; Kelly, Margaret M.

doi:10.1016/j.jaci.2013.01.015

Cited by 69 publications

(65 citation statements)

References 53 publications

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“…That we did not observe a large percentage of Th17 cells in the lungs of exposed mice despite high levels of IL-17 mRNA suggests that other cells also contribute to its production. Hasan et al (20) showed that neutrophils and macrophages were the main cell types that expressed IL-17A in mice exposed to SR for 3 wk. It is possible that neutrophils and macrophages contribute to IL-17 production during the chronic stage of FLD.…”

Section: Discussionmentioning

confidence: 99%

Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response

Andrews

Ghosh

Schwingshackl

et al. 2016

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussionmentioning

confidence: 99%

Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response

Andrews

Ghosh

Schwingshackl

et al. 2016

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…IL-17 expression and a Th17 immune response after 3-4 week exposure to SR is associated with increased disease severity and fibrosis in HP (Hasan et al, 2013;Joshi et al, 2009;Simonian et al, 2009). The results of this study show long term exposure to SR is also associated with a Th17 response.…”

Section: Discussionmentioning

confidence: 52%

“…IL-17 expression is associated with the induction of neutrophil chemokines and neutrophil recruitment in the lung (Hellings et al, 2003;Laan et al, 1999;Miyamoto et al, 2003;Witowski et al, 2000). In addition, recent studies of HP in mice have shown that neutrophils and macrophages were the main cell type that expressed IL-17A in HP, and that neutrophil depletion decreased the amount of lung collagen (Hasan et al, 2013).…”

Section: Chronic Hp Studiesmentioning

confidence: 99%

“…There was no significant increase in the percentage of CD4 − Th cells expressing IL-17A or IL-4 after 14 weeks SR exposure (Figure 5-9C). Recent studies have suggested neutrophils and macrophages also contribute to IL-17 production and the fibrotic response in HP (Hasan et al, 2013). To determine if macrophages are a greater contributor to IL-17A or IL-4 production after long term WT and TLR2/9 −/− mice were exposed to SR 3 times/week for 14 weeks and analyzed 2 days after the last exposure.…”

Section: Cd4 + Th Cells From Mice With Long Term Exposure To Sr Exprementioning

confidence: 99%

“…Other models of lung fibrosis such as bleomycin and IL-1-mediated lung fibrosis have also found IL-17 production by Th17 and γδ T cells is associated with increased lung fibrosis (Wilson et al, 2010). In addition, recent studies in mice have shown that neutrophils and macrophages were the main cell type that expressed IL-17A in HP and that neutrophil depletion decreased the amount of collagen in the lungs after SR exposure (Hasan et al, 2013). However, the role of IL-17 in fibrosis is controversial.…”

Section: Chapter 5 Chronic Phase Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis

Andrews¹

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Fibrogenesis in chronic murine colitis is independent of innate lymphoid cells

Creyns

Cremer

Hertogh

et al. 2020

Immunity Inflam & Disease

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Introduction: Insight in the pathogenesis of intestinal fibrosis is an unmet medical need in inflammatory bowel diseases. Studies in murine models and human organ fibrosis point to a potential role of innate lymphoid cells (ILC) in chronic intestinal inflammation and fibrosis. Materials and Methods: Dextran sodium sulfate (DSS) in drinking water was used to induce chronic colitis and remodeling in C57Bl/6 wild type (WT), RAG-deficient, RAG −/− common γ chain deficient and anti-CD90.2 monoclonal antibody treated RAG −/− mice. Inflammation was scored by macroscopic and histological examination and fibrosis was evaluated by hydroxyproline quantification and histology. Results: In RAG −/− mice (which have a normal ILC population but no adaptive immunity), chronic intestinal inflammation and fibrosis developed similarly as in WT mice, with a relative increase in ILC2 during repeated DSS exposure. Chronic colitis could also be induced in the absence of ILC (RAG −/− γc −/− or anti-CD90.2 treated RAG −/− mice) with no attenuation of fibrosis. Importantly, clinical recovery based on weight gain after stopping DSS exposure was impaired in ILC-deficient or ILC-depleted mice. Conclusion: These data argue against a profibrotic effect of ILC in chronic colitis, but rather suggest that ILC have a protective and recovery-enhancing effect after repeated intestinal injury. K E Y W O R D S Crohn's disease, innate immunity, innate lymphoid cell, intestinal fibrosis 1 | INTRODUCTION Chronic inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are inflammatory intestinal diseases with a relapsingremitting disease course. Throughout their disease course, one-third of CD patients and 5% of UC patients will develop a fibrostenotic phenotype (strictures and bowel

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Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis

Cited by 69 publications

References 53 publications

Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response

Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response

Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis

Fibrogenesis in chronic murine colitis is independent of innate lymphoid cells

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