Role of IGF-1 in neuroinflammation and cognition deficits induced by sleep deprivation

Wan, Yahui; Gao, Wei; Zhou, Kai; Li, Xuan; Jiang, Wei; Xue, Rong; Wu, Wei

doi:10.1016/j.neulet.2022.136575

Cited by 16 publications

(13 citation statements)

References 50 publications

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“…Based on the above, IGF1 is a potential treatment for both syndromic and non-syndromic types of ASD [ 46 , 52 , 53 , 54 ]. Therefore, the upregulation of the Igf1 expression level we measured following HBOT may lead to a cascading effect [ 55 , 56 , 57 ] that may improve brain functionality and behavioral outcomes.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Alleviates Social Behavior Dysfunction and Neuroinflammation in a Mouse Model for Autism Spectrum Disorders

Fischer

Shohat²,

Levy³

et al. 2022

IJMS

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Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder (NDD) characterized by impaired social communication and repetitive behavior, among other symptoms. ASD is highly heritable, with SHANK3 being one of the high-risk genes for ASD. In recent years, knowledge has been growing regarding the neuroplasticity effect induced by hyperbaric oxygen therapy (HBOT) and its potential use for ASD. Here, we characterized the effect of HBOT on a mouse model for ASD with the human genetic condition of InsG3680 mutation in the Shank3 gene. As compared to placebo, HBOT improved social behavior and reduced neuroinflammation in the cortex of the InsG3680(+/+) mice. Specifically, HBOT induced upregulation of Insulin-like growth factor 1 (Igf1) expression levels and reduced the number of Iba1-positive cells in the mouse model for ASD compared to placebo control. Together, our research suggests that HBOT has the potential to improve the clinical outcome of ASD by ameliorating some of the core pathophysiological processes responsible for the development of the disorder.

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Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Alleviates Social Behavior Dysfunction and Neuroinflammation in a Mouse Model for Autism Spectrum Disorders

Fischer

Shohat²,

Levy³

et al. 2022

IJMS

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“…[35] GSEA results helped us conclude that insomnia may result in immune-related, endocrine, and metabolic diseases. Notably, among the GSEA-enriched items, previous studies have proved the role of SD in phosphatidylinositol signaling system, [36] inositol phosphate metabolism, [37,38] hematopoietic cell lineage [39] ; glycine, serine, and threonine metabolism, [40] and estrogen signaling. [41] Sleep is regulated through homeostatic and circadian processes.…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that IGF-1 expression was downregulated after SD, with reduced activation of the downstream PI3K/AKT/GSK3B pathway in mice brains, as well as reduced expression of Bcl-2. [36] Moreover, IGF1R amplified per synthesis rates owing to daytime feeding. [46] GSK3B is a serine-threonine kinase, is downstream of EGFR, had the highest number of targets in the network of PPI, and was associated with severe insomnia patients.…”

Section: Discussionmentioning

confidence: 99%

Molecular targets and mechanisms involved in the action of Banxia Shumi decoction in insomnia treatment

Zhang

Zhang²,

Wang³

et al. 2023

Medicine

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Insomnia is a common sleep-wake rhythm disorder, which is closely associated with the occurrence of many serious diseases. Recent researches suggest that circadian rhythms play an important role in regulating sleep duration and sleep quality. Banxia Shumi decoction (BSXM) is a well-known Chinese formula used to treat insomnia in China. However, the overall molecular mechanism behind this therapeutic effect has not yet been fully elucidated. This study aimed to identify the molecular targets and mechanisms involved in the action of BSXM during the treatment of insomnia. Using network pharmacology and molecular docking methods, we investigated the molecular targets and underlying mechanisms of action of BSXM in insomnia therapy. We identified 8 active compounds from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and the traditional Chinese medicine integrative database that corresponded to 26 target genes involved in insomnia treatment. The compound-differentially expressed genes of the BXSM network indicated that cavidine and gondoic acid could potentially become key components of drugs used for insomnia treatment. Further analysis revealed that GSK3B, MAPK14, IGF1R, CCL5, and BCL2L11 were core targets significantly associated with the circadian clock. Pathway enrichment analysis of Kyoto Encyclopedia of Genes and Genomes revealed that epidermal growth factor receptor tyrosine kinase inhibitor resistance was the most prominently enriched pathway for BSXM in the insomnia treatment. The forkhead box O signaling pathway was also found to be significantly enriched. These targets were validated using the Gene Expression Omnibus dataset. Molecular docking studies were performed to confirm the binding of cavidine and gondoic acid to the identified core targets. To our knowledge, our study confirmed for the first time that the multi-component, multi-target, and multi-pathway characteristics of BXSM may be the potential mechanism for treating insomnia with respect to the circadian clock gene. The results of this study provided theoretical guidance for researchers to further explore its mechanism of action.Abbreviations: BCL2L1 = BCL2 like 1, BSXM = Banxia Shumi decoction, DEGs = differentially expressed genes, EGFR = epidermal growth factor receptor, FOXO = forkhead box O, GO = gene ontology, GA = gondoic acid, GSEA = gene set enrichment analysis, KEGG = Kyoto Encyclopedia of Genes and Genomes, MAPK14 = mitogen-activated protein kinase, MCC = maximum cluster centrality, PPI = protein-protein interaction, ROC = receiver operating characteristic, SD = sleep deprivation, TCM = traditional Chinese medicine.

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“…Also, mice with IGF-1 deficiency showed increased Tnfa and Il1b mRNAs in the retina indicating persistent inflammation (Arroba et al, 2016). In addition, activation of the IGF-1/PI3K/AKT/GSK-3β pathway was shown to attenuate neuro-inflammation and cognitive impairment after sleep deprivation (Wan et al, 2022). LA was shown to prevent losses in body weight and gastrocnemius muscle weight in rats with rheumatoid arthritis exposed to chronic nicotine treatment.…”

Section: Effects Of La On Inflammationmentioning

confidence: 98%

Effects of linalyl acetate on oxidative stress, inflammation and endothelial dysfunction: can linalyl acetate prevent mild cognitive impairment?

Shin

Seol

2023

Front. Pharmacol.

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Mild cognitive impairment (MCI) is a major public health challenge with an increasing prevalence. Although the mechanisms underlying the development of MCI remain unclear, MCI has been reported to be associated with oxidative stress, inflammatory responses, and endothelial dysfunction, suggesting that agents that reduce these factors may be key to preventing MCI. Currently, no agents have been approved for the treatment of MCI, with the efficacy of commonly prescribed cholinesterase inhibitors remaining unclear. Relatively safe natural products that can prevent the development of MCI are of great interest. Linalyl acetate (LA), the major component of clary sage and lavender essential oils, has been shown to have a variety of pharmacological effects, including anti-hypertensive, anti-diabetic, neuroprotective, anti-inflammatory, and antioxidant properties, which may have the potential for the prevention of MCI. The present review briefly summarizes the pathogenesis of MCI related to oxidative stress, inflammatory responses, and endothelial dysfunction as well as the benefits of LA against these MCI-associated factors. The PubMed and Google Scholar databases were used to search the relevant literature. Further clinical research may lead to the development of new strategies for preventing MCI, particularly in high-risk populations with oxidative stress, inflammatory responses, and endothelial dysfunction (e.g., patients with hypertension and/or diabetes mellitus).

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Role of IGF-1 in neuroinflammation and cognition deficits induced by sleep deprivation

Cited by 16 publications

References 50 publications

Hyperbaric Oxygen Therapy Alleviates Social Behavior Dysfunction and Neuroinflammation in a Mouse Model for Autism Spectrum Disorders

Hyperbaric Oxygen Therapy Alleviates Social Behavior Dysfunction and Neuroinflammation in a Mouse Model for Autism Spectrum Disorders

Molecular targets and mechanisms involved in the action of Banxia Shumi decoction in insomnia treatment

Effects of linalyl acetate on oxidative stress, inflammation and endothelial dysfunction: can linalyl acetate prevent mild cognitive impairment?

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