Role of IgD and Tδ Cells in the Regulation of the Humoral Immune Response

Coico, Richard; Siskjnd, Gregory W.; Thorbecke, G. J.

doi:10.1111/j.1600-065x.1988.tb00765.x

Cited by 53 publications

(37 citation statements)

References 51 publications

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“…This may indicate that different ligands drive germinal centre B cells into different differentiation pathways, namely either plasma cell or memory cell generation. That germinal centre B cells can indeed differentiate in either direction is supported by evidence from in vivo experiments (Coico et al, 1983;Tew et al, 1992).…”

Section: Introductionsupporting

confidence: 51%

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

et al. 1993

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Section: Introductionsupporting

confidence: 51%

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

et al. 1993

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“…After exposure to aggregated oligomeric or antigen-crosslinked monomeric secreted IgD, 10 to 15% of human peripheral blood T cells (T␦ cells) exhibit receptors for IgD and form rosettes with IgD-coated erythrocytes (26,27). These receptors are upregulated by interleukin-2 (IL-2), IL-4, and gamma interferon on the T␦ cells.…”

Section: Properties Of Igd and Its Role In The Immune Responsementioning

confidence: 99%

Immunoglobulin D: Properties, Measurement, and Clinical Relevance

Vladutiu

2000

Clin Diagn Lab Immunol

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“…(IL-2), interleukin 4 (IL-4), and interferon 'y also up-regulate IgD-R on CD4' polyclonal or cloned T cells (3)(4)(5). We established the isotypic specificity of these receptors on the T-helper cells bearing receptors for IgD (T8) cells by showing that dimeric IgD, at concentrations -120 tug/ml (1 ItM), competitively inhibits TS resetting, whereas IgM, IgG1, IgG2, IgG3, IgA, or IgE fail to do so (3,5).…”

mentioning

confidence: 99%

“…We established the isotypic specificity of these receptors on the T-helper cells bearing receptors for IgD (T8) cells by showing that dimeric IgD, at concentrations -120 tug/ml (1 ItM), competitively inhibits TS resetting, whereas IgM, IgG1, IgG2, IgG3, IgA, or IgE fail to do so (3,5). The possible physiological significance and role of these IgD-R on T cells in immunoregulation has been discussed (3,6).…”

mentioning

confidence: 99%

Specificity of the murine IgD receptor on T cells is for N-linked glycans on IgD molecules.

Amin

Tamma

Oppenheim

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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IgD receptors on murine T cells have been reported in this issue [Tamma, S. M. L., Amin, A. R., Finkelman, F. D., Chen, Y.-W., Thorbecke, G. J. & Coico, R. F. (1991) Proc. Natl. Acad. Sci. USA 88, 9233-9237] to bind either the first or third constant region of the heavy-chain of IgD molecules--findings that could not be satisfactorily explained by IgD amino acid sequences. We now find that boiled IgD molecules or low-Mr fragments from protease-digested IgD still inhibit binding of IgD-coated erythrocytes to IgD receptors. This inhibitory activity can be absorbed with the murine IgD-binding lectin from Griffonia simplicifolia 1 (GS-1) immobilized on Sepharose. N-linked glycans, obtained from N-glycanase-treated IgD and purified by binding to GS-1-Sepharose, also inhibit rosette formation of T-helper cells bearing receptors for IgD with IgD- or mutant IgD-coated erythrocytes. Deglycosylated IgD, produced by treatment with N-glycanase, no longer binds to the lectin and fails to inhibit IgD rosetting. Binding of intact IgD to T cells is also competitively inhibited by N-acetylgalactosamine, galactose, N-acetylglucosamine, and neoglycoproteins containing these sugars. These results clearly show that N-linked glycans, present in both the first and third constant regions of the delta heavy-chain domains, are prerequisites for binding of IgD to IgD receptors.

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Role of IgD and Tδ Cells in the Regulation of the Humoral Immune Response

Cited by 53 publications

References 51 publications

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

Immunoglobulin D: Properties, Measurement, and Clinical Relevance

Specificity of the murine IgD receptor on T cells is for N-linked glycans on IgD molecules.

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