Role of <i><scp>H</scp>elicobacter pylori</i> in common rosacea subtypes: A genotypic comparative study of <scp>E</scp>gyptian patients

El‐Khalawany, Mohamed; Mahmoud, Alì Mokhtar; Mosbeh, Al-Sadat; Al-Salam, Fatma Abd; Ghonaim, Noha; Abou-Bakr, Amany A

doi:10.1111/j.1346-8138.2012.01675.x

Cited by 27 publications

(28 citation statements)

References 23 publications

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“…Many reports have been published on the prevalence of H. pylori infection among patients with rosacea (11,(18)(19)(20)(21)(22)(23), which ranges from studies reporting prevalence of 100% to studies indicating no significant difference between healthy people and the rosacea group (24, 25). Despite intense investigations on the spread of rosacea, the precise etiology remains unclear.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Helicobacter pylori Infection and Rosacea

Saleh

Naghavi-Behzad

Babapour

et al. 2018

Arch Clin Infect Dis

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Introduction: Helicobacter pylori (H. pylori) is one the most infectious microorganism of human disease found in half of the world's population. Despite intense investigations into the spread of rosacea, the precise etiology remains unclear. There are theories, which suggest H. pylori as a predisposing factor for the occurrence. This study aimed at determining the prevalence of H. pylori in patients with rosacea. Methods: This analytical-descriptive study was conducted on patients with rosacea disease attending Tabriz University of Medical Sciences Dermatology Clinics from October 2011 to January 2011. Patients, who were 18-to 65-year-olds with confirmed rosacea diagnosis, were included in the study. All patients were referred to a dermatologist and the severity of rosacea was categorized in 3 grades of mild, moderate and severe. Then H. pylori infection was investigated using H. pylori stool antigen. P values of less than 0.05 were considered statistically significant. Results: Out of 63 patients with rosacea, 35 patients (55.55%) were male and 28 patients (44.44%) were female. Based on the rosacea categorization, 11 (17.46%), 32 (50.79%), and 20 (31.74%) patients had respectively severe, moderate, and mild rosacea. There was no statistical significant difference regarding age and gender between different severities (P = 0.39). Forty patients (63.4%) out of all 63 were positive for H. pylori on stool antigen examination. There was no statistically significant association between H. pylori infection and gender (P = 0.87) or age (P = 0.62). There was a statistically significant difference between patients with H. pylori negative and positive test results considering severity (P = 0.013). Conclusions:In conclusion, although no association between rosacea and H. pylori infection was seen, there was a significant association between H. pylori infection and cases of severe rosacea.

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Section: Introductionmentioning

confidence: 99%

The Association Between Helicobacter pylori Infection and Rosacea

Saleh

Naghavi-Behzad

Babapour

et al. 2018

Arch Clin Infect Dis

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“…Other authors suggest a causal relationship between the two disorders, based on the RS clinical improvement after HP treatment (2,3,4,5) and the high incidence of this microorganism in RS patients (6,7). Improvment in the symptomatology of the disease noticed after the treatment of HP infection is supported by several studies, while other authors consider that this treatment and RS evolution are not connected (8,9).…”

Section: Results Resultsmentioning

confidence: 67%

“…In their study, 67% of the patients with RS with dyspeptic symptoms had anti-CagA (cytotoxin associated gene A) antibodies compared to 32% of the patients without RS but complaining of dyspepsia (11). At a later date Argenziano et al confirmed a predominance of anti-Cag A antibodies in RS patients (10) and El-Khalawany M et al recently proved that this virulent strain of HP is more frequently positive in papulo-pustular cases and its presence is responsible for an ampler inflammatory response in both gastric mucosa and cutaneous lesions (7).…”

Section: Results Resultsmentioning

confidence: 99%

Rosacea and its comorbidities

Merticariu¹,

Marinescu²,

Giurcăneanu³

2016

JTMR

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Objectives: Rosacea is currently defined as an inflammatory cutaneous disease without systemic echoes. The objective of our paper is to review the published articles to confirm our belief that rosacea is associated to or can predispose to various diseases, mainly inflammatory diseases. Material and methods:Review all the papers published in the last two decades in PubMed, Google Academic and Medscape databases, linking rosacea and various disorders of the body systems. Results: We found that rosacea is associated to several illnesses of major systems (gastrointestinal, cardiovascular, respiratory) and that there are also links between rosacea and immune system disorders and psychiatric diseases. Rosacea clinical course can be influenced by various drugs prescribed for the previous mentioned diseases. Conclusions: Rosacea should no longer be considered a localized cutaneous condition but rather a complex pathology with systemic reverberation. Patients suffering of severe forms of rosacea for a long period of time should have a careful evaluation of body systems.

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“…Before the test, the patients were asked to eat or drink nothing for 6 h. Antacids and H2 receptor antagonists were discontinued 24 h before the test. One week prior to the test, proton pump inhibitors and sucralfate were stopped (17). Antibiotics were discontinued over a month before the test.…”

Section: C14 Ubtmentioning

confidence: 99%

“…Gastric ulceration and carcinogenesis are associated with HP infection (11). HP infection has been linked to various autoimmune dermatological diseases, such as alopecia areata, Behçet's disease, chronic urticaria, pruritus, psoriasis, and rosacea (12)(13)(14)(15)(16)(17). The frequency of HP has not been studied in patients with vitiligo.…”

Section: Introductionmentioning

confidence: 99%

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

Rifaioğlu¹,

Aydogan²,

Şen³

et al. 2014

Turk J Med Sci

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IntroductionVitiligo is an acquired depigmenting skin disorder. It occurs clinically by the appearance of well-circumscribed, asymptomatic, white macules following the loss of functional melanocytes in the epidermis (1). The prevalence rate of vitiligo ranges from 0.06% to 2.28% in the population (2). The main etiopathogenesis of vitiligo is multifactorial. According to various pathophysiological theories, it may be associated with autoimmunity, neurogenic dysregulation, autocytotoxicity, biochemical dysregulation, oxidative stress, and weak melanocyte viability (1,(3)(4)(5)(6). Several potentially environmental factors such as infectious agents appear to be related with vitiligo (7-9).Helicobacter pylori (HP) is a major health problem affecting about 50% of the world population (10). Gastric ulceration and carcinogenesis are associated with HP infection (11). HP infection has been linked to various autoimmune dermatological diseases, such as alopecia areata, Behçet's disease, chronic urticaria, pruritus, psoriasis, and rosacea (12-17). The frequency of HP has not been studied in patients with vitiligo. Noninvasive tests such as the carbon 13 or carbon 14 (C14) urea breath test (UBT), stool antigen tests, and serology are used to detect HP infection (18). In this study, we used the C14 UBT to detect the frequency of HP infection in patients with vitiligo. Materials and methods Patient and control groupsWith the approval of the local ethics committee, a prospective study was conducted in our dermatology department clinic. The study comprised 34 patients with vitiligo and 30 age-and sex-matched healthy controls. The patients with vitiligo were newly diagnosed and older than 16 years. The patients with gastrointestinal symptoms or those who had received eradication therapy for HP earlier were excluded from the study. Other exclusion criteria were age under 16 years, pregnancy or lactation, and the use of antibiotics, proton pump inhibitors, or H2 blockers in the 40, 7, and 14 days, respectively, leading up to sample collection. According to the working clinical classification, vitiligo was classified as vitiligo vulgaris, acrofacial, focal, segmental, universal, or mucosal (16).Background/aim: Vitiligo is a common, acquired depigmenting skin disorder. The relationship between Helicobacter pylori (HP) infection and autoimmune dermatological disease has been previously reported. However, the frequency of HP infection in patients with vitiligo has not been reported. In this study, we aimed to investigate the frequency of HP infection with the carbon 14 (C14) urea breath test (UBT) in patients with vitiligo. Materials and methods:This study included 34 patients (18 males and 16 females) with vitiligo and 30 age-and sex-matched healthy controls. HP infection was diagnosed using the C14 UBT (Heliprobe). Statistical analysis was performed using SPSS 19. Results:The frequency of HP infection was 64.7% in the patient group and 33.3% in the control group according to the C14 UBT (chisquare test, P = 0.012). HP infection frequ...

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Role of Helicobacter pylori in common rosacea subtypes: A genotypic comparative study of Egyptian patients

Cited by 27 publications

References 23 publications

The Association Between Helicobacter pylori Infection and Rosacea

The Association Between Helicobacter pylori Infection and Rosacea

Rosacea and its comorbidities

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

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