Role of
            <i>Porphyromonas gingivalis</i>
            SerB in Gingival Epithelial Cell Cytoskeletal Remodeling and Cytokine Production

Hasegawa, Yoshinori; Tribble, Gena D.; Baker, Henry V.; Mans, Jeffrey J.; Handfield, Martin; Lamont, Richard J.

doi:10.1128/iai.00156-08

Cited by 75 publications

(79 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This experiment indicated that MtSerB2 acted in a similar capacity as SerB653 from Porphyromonas gingivalis (P. gingivalis), previously shown to induce microtubule rearrangement in HIGK cells (human immortalized gingival Fig. 1 continued keratinocytes) [35,37,38]. Recently, the same group published a follow-up study and showed that MtSerB2 was secreted in the cytoplasm of infected THP1 macrophages [30].…”

Section: Serb2mentioning

confidence: 66%

Bacterial Virulence Factors: Secreted for Survival

et al. 2016

View full text Add to dashboard Cite

Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature. The cytosolic factors facilitate the bacterium to undergo quick adaptive-metabolic, physiological and morphological shifts. The membrane associated virulence factors aid the bacterium in adhesion and evasion of the host cell. The secretory factors are important components of bacterial armoury which help the bacterium wade through the innate and adaptive immune response mounted within the host. In extracellular pathogens, the secretory virulence factors act synergistically to kill the host cells. In this review, we revisit the role of some of the secreted virulence factors of two human pathogens: Mycobacterium tuberculosis-an intracellular pathogen and Bacillus anthracis-an extracellular pathogen. The advances in research on the role of secretory factors of these pathogens during infection are discussed.

show abstract

Section: Serb2mentioning

confidence: 66%

Bacterial Virulence Factors: Secreted for Survival

et al. 2016

View full text Add to dashboard Cite

show abstract

“…It was proposed that this could facilitate survival and multiplication of the entire microbial community [59]. P. gingivalis can block gingival epithelial cells IL-8 production in vitro, by secreting a serine phosphatase that inhibits the synthesis of IL-8 [60]. This process can delay the recruitment of neutrophils preventing the proper formation of the neutrophil wall, facilitating initial microbial colonization of the periodontium [61].…”

Section: Host Defense Mechanismsmentioning

confidence: 99%

Impact of Dental Plaque Biofilms in Periodontal Disease: Management and Future Therapy

Lazăr¹,

Dițu²,

Curuţiu³

et al. 2017

Periodontitis - A Useful Reference

View full text Add to dashboard Cite

Oral cavity represents an ideal environment for the microbial cell growth, persistence, and dental plaque establishment. The presence of different microniches leads to the occurrence of different biofilm communities, formed on teeth surface, above gingival crevice or at subgingival level, on tongue, mucosa and dental prosthetics too. The healthy state is regulated by host immune system and interactions between microbial community members, maintaining the predominance of "good" microorganisms. When the complexity and volume of biofilms from the gingival crevice increase, chronic pathological conditions such as gingivitis and periodontitis can occur, predisposing to a wide range of complications. Bacteria growing in biofilms exhibit a different behavior compared with their counterpart, respectively planktonic or free cells. There have been described numerous mechanisms of differences in antibiotic susceptibility of biofilm embedded cells. Resistance to antibiotics, mediated by genetic factors or, phenotypical, due to biofilm formation, called also tolerance, is the most important cause of therapy failure of biofilm-associated infections, including periodontitis; the mechanisms of tolerance are different, the metabolic low rate and cell's dormancy being the major ones. The recent progress in science and technology has made possible a wide range of novel approaches and advanced therapies, aiming the efficient management of periodontal disease.

show abstract

“…Clients generally find it easier to identify the cognitive distortions and biased thinking of others and then apply the skill to their own cognitions, with group members frequently filling the role of co-therapists [24]. The group setting also provides an opportunity for modelling the desired behaviours by group facilitators and members by displaying empathy, support and encouragement, as well as promoting change via challenging negative automatic thoughts and distorted cognitions.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Group CBT Vs Group Information and Support in Relapse and Recurrence of Depression in Adults

Cassidy¹

2016

JPCPY

View full text Add to dashboard Cite

This study aimed to analyse the rates and length of time to relapse and/or recurrence of depression in individuals who attended either Group CBT or Group Information and Support in an adult secondary mental health setting in Ireland. The present study centred on the analysis of previously collected data from groups running between 2005 and 2010 and on the retrospective file review. It formed part of a larger scale research study conducted by the Principal Clinical Psychologist evaluating the effectiveness of CBT for depression and bipolar disorder. The study was quantitative in nature and incorporated qualitative elements (i.e. Clients' and Practitioners' description of the severity of the depressive episodes) which were converted into quantifiable categories. Participants comprised of two groups: Treatment I (Group CBT) including participants who attended 8 or 12 sessions of manualised Group CBT and a comparison sample: Treatment II (Group Information and Support) comprised of participants who attended 12 sessions of group information and support. Based on survival analysis, no significant difference was found in effectiveness for Group CBT and Group Information and Support in preventing and/or decreasing the number and the length of time to relapse and/or recurrence of depression in this client group. Findings, clinical implications, methodological limitations and future research directions were also discussed.

show abstract

Role of Porphyromonas gingivalis SerB in Gingival Epithelial Cell Cytoskeletal Remodeling and Cytokine Production

Cited by 75 publications

References 60 publications

Bacterial Virulence Factors: Secreted for Survival

Bacterial Virulence Factors: Secreted for Survival

Impact of Dental Plaque Biofilms in Periodontal Disease: Management and Future Therapy

Efficacy of Group CBT Vs Group Information and Support in Relapse and Recurrence of Depression in Adults

Contact Info

Product

Resources

About