Role of <i>p</i>H-responsiveness in the design of chitosan-based cancer nanotherapeutics: A review

Suarato, Giulia; Li, Weiyi; Meng, Yizhi

doi:10.1116/1.4944661

Cited by 34 publications

(20 citation statements)

References 145 publications

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“…CS has been proven to be a useful and effective carrier for microspheres drug delivery through the inhalation route due to its low toxicity, biocompatibility, biodegradability, and mucoadhesive properties as well as macromolecule permeation enhancement. 18 , 19 It has been confirmed that spray-dried CS microspheres have a low toxicity in cell lines of human origin from airway and alveolar regions of the pulmonary tract; this is an encouraging index for the safe use of the dry powder inhalation. 20 …”

Section: Introductionmentioning

confidence: 86%

Preparation of novel pirfenidone microspheres for lung-targeted delivery: in vitro and in vivo study

Li¹,

Gong²

2016

DDDT

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The aim of this study was to develop and characterize pirfenidone (PF)-loaded chitosan microspheres for lung targeting. The microspheres were prepared using the emulsion-solvent evaporation method and characterized by assessing morphology, particle size, and zeta potential. The microspheres had a spherical nature with highly smooth and integrated surfaces. The particle size of microspheres was 4.6±0.3 µm, and the zeta potential was 20.3±1.4 mV. The in vitro release results indicated that the obtained formulation of PF could reach the state of sustained release with a biphasic drug release pattern. It was observed that there was no significant difference in both the percentage of entrapment efficiency and that of drug release before and after the stability study. In vivo, the calculated relative bioavailability indicated greater pulmonary absorption of PF when it was encapsulated in microspheres. According to histopathological studies, no histological change occurred to the rat lung after the administration of PF-loaded chitosan microspheres.

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Section: Introductionmentioning

confidence: 86%

Preparation of novel pirfenidone microspheres for lung-targeted delivery: in vitro and in vivo study

Li¹,

Gong²

2016

DDDT

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“…Cancer cells expose increased content of anionic PS in the outer leaflet of the cytoplasmic membrane, favoring electrostatic interactions (Zwaal et al, 2005) as in the case of antibacterial activity. Other appealing features of chitosan should be considered as its facilitated adsorption at the cancer cell membrane due to electrostatic interactions and to the presence of secondary and tertiary amino groups, and the abundant possibilities of hydrogen-bonding that enhances for longer the adhesive effect (Suarato, Li, & Meng, 2016). From our set of compounds, CH50 was the only derivative endowed with significant activity toward HeLa cells.…”

Section: Discussionmentioning

confidence: 99%

Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes

Martins

Nasário²,

Silva-Gonçalves

et al. 2018

Carbohydrate Polymers

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The antimicrobial activity of chitosan and derivatives to human and plant pathogens represents a high-valued prospective market. Presently, two low molecular weight derivatives, endowed with hydrophobic and cationic character at different ratios were synthesized and characterized. They exhibit antimicrobial activity and increased performance in relation to the intermediate and starting compounds. However, just the derivative with higher cationic character showed cytotoxicity towards human cervical carcinoma cells. Considering cell membranes as targets, the mode of action was investigated through the interaction with model lipid vesicles mimicking bacterial, tumoral and erythrocyte membranes. Intense lytic activity and binding are demonstrated for both derivatives in anionic bilayers. The less charged compound exhibits slightly improved selectivity towards bacterial model membranes, suggesting that balancing its hydrophobic/hydrophilic character may improve efficiency. Observing the aggregation of vesicles, we hypothesize that the "charge cluster mechanism", ascribed to some antimicrobial peptides, could be applied to these chitosan derivatives.

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“…Chitosan is insoluble in neutral and alkaline environments, but it is soluble in acidic environments due to the conversion of NH 2 to NH 3 + groups. Chitosan pH-dependent behavior makes it an appropriate carrier to release cancer drugs that can reduce the side effects of anticancer drugs [29,36].…”

Section: Stimuli-responsive Chitosan Carriermentioning

confidence: 99%

A Critical Comparison Study on the pH-Sensitive Nanocomposites Based on Graphene-Grafted Chitosan for Cancer Theragnosis

Gooneh-Farahani

Naghib

Naimi‐Jamal

2019

Multidiscip Cancer Investig

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Drug delivery is one of the major issues in the world of science, which receives a large part of the research in various fields. The ultimate goal of drug delivery is to help the patient with developing advanced drug delivery systems. These systems revolutionize the treatment of many diseases including cancer. Effective drug carriers can significantly reduce the undesirable side effects of anticancer drugs through the drug controlled release and using the selective drug to cancerous tissue. The natural biocompatible and biodegradable polymer of chitosan is widely investigated in drug delivery systems, especially as the carrier for anticancer drugs. An important aspect for the application of chitosan in drug delivery for cancer treatment is its pH sensitivity. Graphene attracted much attention in various fields as a shining star in the science of materials. In recent years, the use of graphene in the diagnosis and treatment of cancer is also investigated. Therefore, chitosan-graphene nanocomposite can be introduced as a pH-sensitive carrier for cancer theragnosis. In the current study, the application of chitosan and graphene in the treatment of cancer addressed in previous years was discussed.

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Role of pH-responsiveness in the design of chitosan-based cancer nanotherapeutics: A review

Cited by 34 publications

References 145 publications

Preparation of novel pirfenidone microspheres for lung-targeted delivery: in vitro and in vivo study

Preparation of novel pirfenidone microspheres for lung-targeted delivery: in vitro and in vivo study

Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes

A Critical Comparison Study on the pH-Sensitive Nanocomposites Based on Graphene-Grafted Chitosan for Cancer Theragnosis

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