Role of <i>IL-1β</i> rs1143634 (+3954C&gt;T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis

Jafrin, Sarah; Aziz, Abdul; Islam, Mohammad Safiqul

doi:10.1177/03000605211060144

Cited by 11 publications

(11 citation statements)

References 72 publications

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“…These associations highlight their potential roles in maintaining liver health and immune system support. The associations found in our study are consistent with the results of other similar studies, where gene function and SNP associations suggest a multifactorial approach through different mechanisms or platforms and have been discussed in common pathophysiological pathways [ 11 , 13 , 17 ].…”

Section: Discussionsupporting

confidence: 92%

Genetical Signature—An Example of a Personalized Skin Aging Investigation with Possible Implementation in Clinical Practice

Sepetiene,

Patamsyte,

Valiukevicius

et al. 2023

JPM

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We conducted a research study to create the groundwork for personalized solutions within a skin aging segment. This test utilizes genetic and general laboratory data to predict individual susceptibility to weak skin characteristics, leveraging the research on genetic polymorphisms related to skin functional properties. A cross-sectional study was conducted in a collaboration between the Private Clinic Medicina Practica Laboratory (Vilnius, Lithuania) and the Public Institution Lithuanian University of Health Sciences (Kaunas, Lithuania). A total of 370 participants agreed to participate in the project. The median age of the respondents was 40, with a range of 19 to 74 years. After the literature search, we selected 15 polymorphisms of the genes related to skin aging, which were subsequently categorized in terms of different skin functions: SOD2 (rs4880), GPX1 (rs1050450), NQO1 (rs1800566), CAT (rs1001179), TYR (rs1126809), SLC45A2 (rs26722), SLC45A2 (rs16891982), MMP1 (rs1799750), ELN (rs7787362), COL1A1 (rs1800012), AHR (rs2066853), IL6 (rs1800795), IL1Beta (rs1143634), TNF-α (rs1800629), and AQP3 (rs17553719). RT genotyping, blood count, and immunochemistry results were analyzed using statistical methods. The obtained results show significant associations between genotyping models and routine blood screens. These findings demonstrate the personalized medicine approach for the aging segment and further add to the growing literature. Further investigation is warranted to fully understand the complex interplay between genetic factors, environmental influences, and skin aging.

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Section: Discussionsupporting

confidence: 92%

Genetical Signature—An Example of a Personalized Skin Aging Investigation with Possible Implementation in Clinical Practice

Sepetiene,

Patamsyte,

Valiukevicius

et al. 2023

JPM

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“…This is a synonymous variant (p.Phe105=) reported in ClinVar [23] as associated with antisynthetase syndrome and endometriosis. Jafrin, Aziz, & Islam (2021) performed a meta-analysis which revealed that the presence of this polymorphism increases the risk of cancer development, more precisely gastric and breast cancers and multiple myeloma, especially in Asian populations [24]. Several studies connect rs1143634 with chronic periodontitis, including a meta-analysis by da Silva et al (2017), in which it was signi cantly associated with chronic periodontitis disease in Caucasian, Asian and mixed populations [25].…”

Section: Discussionmentioning

confidence: 99%

Identification of Human Genetic Variants Modulating the Course of Covid-19 Infection

Ašić

Salihefendić²,

Čeko³

et al. 2023

Preprint

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COVID-19, caused by the SARS-CoV-2 virus, has been a major focus of scientific research since late 2019 and early 2020. Due to its enormous societal, economic, and clinical impact worldwide, research efforts aimed, among other questions, to address the effect of host genetics in susceptibility and severity of COVID-19. In this research, we performed next-generation sequencing of coding and regulatory regions of 16 selected human genes, involved in the maintenance of the immune system or encoding the receptors for viral entry into the host cells, in a subset of 60 COVID-19 patients from the General Hospital Tešanj, Bosnia and Herzegovina, classified into three groups of patients with clinical conditions of different severity (“mild”, “moderate”, and “severe” clinical groups). In accordance with previous studies, we found out that the male sex and older age are risk factors for severe clinical picture. We identified 13 variants on seven genes (CD55, IL1B, IL4, IRF7, DDX58, TMPRSS2, and ACE2) with potential functional significance, either as genetic markers of modulated susceptibility to SARS-CoV-2 infection or as modifiers of the course of infection in terms of predicted symptom severity. Our results include variants reported for the first time as potentially associated with COVID-19. Future studies on larger patient cohorts, focused on candidate genes and/or candidate genetic variants, have a potential to answer a range of open questions regarding the effect of host (human) genetic makeup on the expected outcome of COVID-19.

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“…This is a synonymous variant (p.Phe105=) reported in ClinVar ( Landrum et al, 2018 ) as associated with antisynthetase syndrome and endometriosis. Jafrin, Aziz and Islam (2021) performed a meta-analysis which revealed that the presence of this polymorphism increases the risk of cancer development, more precisely gastric and breast cancers and multiple myeloma, especially in Asian populations ( Jafrin et al, 2021 ). Several studies connect rs1143634 with chronic periodontitis, including a meta-analysis by da Silva et al (2017) , in which it was significantly associated with chronic periodontitis disease in Caucasian, Asian and mixed populations ( da Silva et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of human genetic variants modulating the course of COVID-19 infection with importance in other viral infections

Salihefendić,

Čeko,

Bešić

et al. 2023

Front. Genet.

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Introduction: COVID-19 has been a major focus of scientific research since early 2020. Due to its societal, economic, and clinical impact worldwide, research efforts aimed, among other questions, to address the effect of host genetics in susceptibility and severity of COVID-19.Methods: We, therefore, performed next-generation sequencing of coding and regulatory regions of 16 human genes, involved in maintenance of the immune system or encoding receptors for viral entry into the host cells, in a subset of 60 COVID-19 patients from the General Hospital Tešanj, Bosnia and Herzegovina, classified into three groups of clinical conditions of different severity (“mild,” “moderate,” and “severe”).Results: We confirmed that the male sex and older age are risk factors for severe clinical picture and identified 13 variants on seven genes (CD55, IL1B, IL4, IRF7, DDX58, TMPRSS2, and ACE2) with potential functional significance, either as genetic markers of modulated susceptibility to SARS-CoV-2 infection or modifiers of the infection severity. Our results include variants reported for the first time as potentially associated with COVID-19, but further research and larger patient cohorts are required to confirm their effect.Discussion: Such studies, focused on candidate genes and/or variants, have a potential to answer the questions regarding the effect of human genetic makeup on the expected infection outcome. In addition, loci we identified here were previously reported to have clinical significance in other diseases and viral infections, thus confirming a general, broader significance of COVID-19-related research results following the end of the pandemic period.

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Role of IL-1β rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis

Cited by 11 publications

References 72 publications

Genetical Signature—An Example of a Personalized Skin Aging Investigation with Possible Implementation in Clinical Practice

Genetical Signature—An Example of a Personalized Skin Aging Investigation with Possible Implementation in Clinical Practice

Identification of Human Genetic Variants Modulating the Course of Covid-19 Infection

Identification of human genetic variants modulating the course of COVID-19 infection with importance in other viral infections

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