Role ofBicDRin bristle shaft construction, tracheal development, and support ofBicDfunctions
Aleksandra Jejina,
Yeniffer Ayala,
Greco Hernández
et al.
Abstract:Cell polarization requires asymmetric localization of numerous mRNAs, proteins, and organelles. The movement of cargo towards the minus end of microtubules mostly depends on cytoplasmic dynein motors, which function as multiprotein complexes. In the dynein/dynactin/Bicaudal-D (DDB) transport machinery, Bicaudal-D (BicD) links the cargo to the motor. Here we focus on the role of BicD-related (BicDR) and its contribution to microtubule-dependent transport processes. Drosophila BicDR is required for the normal de… Show more
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