Role of I-123 MIBG in sepsis-induced cardiomyopathy

Waqar, Fahad; Jamali, Hina K.; Gerson, Myron C.

doi:10.1007/s12350-016-0659-0

Cited by 2 publications

(1 citation statement)

References 26 publications

(23 reference statements)

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“…Iodine 131 and 123 isotopes are used in thyroid scintigraphy to assess thyroid function and detect metastases [ 9 ]. Scintigraphy is also important in assessing the prognosis in patients with heart failure, where the catecholamine analog, 123I-meta-iodobenzylguanidine (MIBG), is employed [ 10 ]. Radioiodine therapy is an effective treatment in the case of hyperthyroidism in patients with Graves’ disease, toxic adenoma, and toxic multinodular goiter, and in patients with well-differentiated thyroid cancer [ 11 ].…”

Section: Application Of Iodine In Medicinementioning

confidence: 99%

The Impact of Iodine Concentration Disorders on Health and Cancer

et al. 2022

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Iodine deficiency is an ongoing problem. The implementation of salt iodization has significantly reduced the effects of iodine deficiency worldwide in recent years, and the remaining iodine deficiency is mild to moderate. Iodine is an essential substrate for the synthesis of thyroid hormones in the thyroid gland. It can also act as an antioxidant, as well as an anti-proliferative and pro-apoptotic factor. Pregnant women, breastfeeding women, and children are particularly affected by iodine deficiency. It leads to thyroid diseases and metabolic and developmental disorders, as well as cancer. However, an excessive iodine intake may, similarly to iodine deficiency, lead to the development of goiter, and toxic amounts of iodine can lead to thyroiditis, hyperthyroidism, and hypothyroidism, and even to the development of papillary thyroid cancer. Correcting iodine deficiency potentially reduces the chance of developing malignancies. Additional research is needed to better understand both the effect of iodine on carcinogenesis and the clinical outcome of iodine deficiency compensation on cancer patients’ prognosis. The upcoming public health challenge appears to be reducing salt consumption, which could result in a lower iodine intake. Thus, an iodine enrichment vehicle other than salt could be considered if salt iodine levels are not increased to compensate, and urine iodine levels should be monitored more frequently.

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Section: Application Of Iodine In Medicinementioning

confidence: 99%

The Impact of Iodine Concentration Disorders on Health and Cancer

et al. 2022

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Incidence, prognosis, and risk factors of sepsis-induced cardiomyopathy

Liang¹,

Zhu²,

Zhang³

et al. 2021

WJCC

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BACKGROUND At present, large-scale studies on the clinical characteristics of sepsis-induced cardiomyopathy (SIC) are lacking. AIM To investigate the clinical characteristics of SIC. METHODS Based on the analysis of the MIMIC-III public database, we performed a large-scale retrospective study involving sepsis patients who were admitted to the intensive care unit (ICU) and had no concomitant cardiac disease. We used propensity score matching analysis and multivariate logistic regression to ensure the robustness of the results. The primary outcome was hospital mortality, and the secondary outcomes included the number of patients who received mechanical ventilation or renal replacement therapy during their hospital stay, the number of patients administered with vasopressors, the length of ICU stay, and the length of hospital stay. RESULTS In the present study, after screening 38605 patients, 3530 patients with sepsis were included. A total of 997 patients met the SIC diagnostic criteria, and the incidence of SIC was 28.20% (95% confidence interval [CI]: 26.80%-29.70%). Compared to patients in the non-SIC group, patients in the SIC group were of older age and had a higher Simplified Acute Physiology Score (SAPS)-I score, SAPS-II score, and Elixhauser comorbidity index (ECI). A total of 367 (36.8%) of 997 patients in the SIC group and 818 (32.3%) of 2533 patients in the non-SIC group died in the hospital, which resulted in a significant between-group difference (odds ratios = 1.22, 95%CI: 1.05-1.42; P = 0.011). For the secondary outcomes, more patients in the SIC group received mechanical ventilation and vasopressors. Multivariate logistic regression analysis showed that age, male sex, ECI, hemoglobin level, diabetes, and mechanical ventilation use on the first day of ICU admission were risk factors for SIC. CONCLUSION Compared with non-SIC patients, hospital mortality is higher in SIC patients.

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Role of I-123 MIBG in sepsis-induced cardiomyopathy

Cited by 2 publications

References 26 publications

The Impact of Iodine Concentration Disorders on Health and Cancer

The Impact of Iodine Concentration Disorders on Health and Cancer

Incidence, prognosis, and risk factors of sepsis-induced cardiomyopathy

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