Role of hydrolytic degradation of polylactide drug carriers in developing micro- and nanoscale polylactide-based drug dosage forms

Preparation and Drug-release Properties of Poly (lactic-<i>co</i>-glycolic acid) Microparticles Co-encapsulating Lidocaine and Capsaicin

“…Poly (lactic glycolic acid) (PLGA)is one of the biocompatible and biodegradable copolymers used in medical devices 18 20) and has been approved in some specific applications by the FDA(Food and Drug Administration of the United States Department of Health and Human Service) 21 23) . Importantly, PLGA is hydrolysed to lactic acid and glycolic acid by de esterification involving esterase enzymes and is excreted as carbon dioxide and water via respiration, stool, and urine 24,25) .…”