Role of HSP in the Treatment of Internal Diseases

Akan, Ozden Yildirim; Ortan, Pınar; Hoşgörler, Ferda

doi:10.1007/978-3-030-24285-5_16

Cited by 2 publications

(1 citation statement)

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“…Heat shock protein (HSP) molecules have different roles depending on their intracellular or extracellular expression. They are mainly involved in the degradation and clearance of misfolded proteins as well as in chaperone-mediated autophagy, protein quality control mechanisms, cell signaling, stress response formation, and kidney self-defense systems [3]. In rat models, HSP-60 stains primarily in the proximal tubule cells and less intensely in the distal convoluted tubule cells.…”

Section: Introductionmentioning

confidence: 99%

The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease

Yıldırım¹,

Tatar²

2022

Cureus

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IntroductionThe exact mechanisms of obesity-related kidney disease (ORKD) are not fully known. Heat shock proteins (HSPs) may play a role in ORKD mechanisms because of their role in cell apoptosis, cytoprotection, and inflammatory processes. We aimed to determine the role of circulating serum HSP-60 and HSP-70 levels as a biomarker for ORKD. Materials and methodsThis study included 40 ORKD patients, 40 obese age-matched and sex-matched controls with similar body mass index (BMI), and 40 healthy controls. Their serum biochemical and hemogram parameters as well as HSP-60 and HSP-70 levels were evaluated and compared. Their neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein levels were assessed to define inflammation. ResultsThe patients had significantly higher HSP-60 levels than the obese and healthy controls (537.58 ± 170.35, 430.80 ± 110.61, and 371.85 ± 76.34, respectively; p<0.00). The results revealed that the 24-hour urinary protein levels had a positive correlation (r= 0.544), whereas the glomerular filtration rate had a negative correlation (r = 0.38) with the serum HSP-60 level. According to the regression analysis performed on the HSP-60 and 24-hour urinary protein excretion levels, an increase in the HSP-60 level significantly increased the 24-hour urinary protein excretion rate (r=0.15; p<0.005). The HSP-60 levels were correlated with inflammatory markers ConclusionThe serum HSP-60 levels increased in patients with ORKD. This increase was correlated with 24-hour urinary protein excretion. Increased circulating levels of HSP-60 may play a role in the initiation and/or progression of renal damage and inflammation. HSP-60 is a potential biomarker for ORKD. However, additional information and studies are required to further elucidate this finding.

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Section: Introductionmentioning

confidence: 99%