Role of HPV in cutaneous premalignant and malignant tumors

Pfister, Herbert; Schegget, Jan ter

doi:10.1016/s0738-081x(96)00162-9

Cited by 120 publications

(106 citation statements)

References 83 publications

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“…These patients have a high risk of developing HPV-positive nonmelanoma skin cancer. Cutaneous HPV is commonly found among the immunocompetent both in benign and malignant skin lesions (11) and on healthy skin (12). In case-control studies, presence of HPV of the h2 species has been associated with SCC (13,14).…”

Section: Introductionmentioning

confidence: 99%

Staphylococcus aureusand Squamous Cell Carcinoma of the Skin

Kullander

Forslund

Dillner

2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Squamous cell carcinoma (SCC) of the skin is a tumor with greatly increased incidence among immunosuppressed patients; therefore, an infectious cause of SCC has long been sought. We performed a hospital-based case-control study of Staphylococcus aureus and biopsies of SCC (n = 82), basal cell carcinoma (n = 142), actinic keratosis (n = 57), and seborrhoeic keratosis (n = 72) in comparison with biopsies from healthy skin of these 353 immunocompetent patients. In a S. aureusspecific PCR, targeting the nuc gene, presence of S. aureus DNA was strongly associated with SCC (29.3% positive specimens; adjusted odds ratio, 6.23; 95% confidence interval, 3.10-12.53) compared with healthy skin (5.7% positive specimens). There was also a tendency for association of S. aureus with actinic keratosis, but no association was found for basal cell carcinoma or seborrhoeic keratosis. Analysis using cotton swab samples taken on top of the lesions and from healthy skin gave similar results (adjusted odds ratio for SCC compared with healthy skin, 2.67; 95% confidence interval, 1.47-4.83). In conclusion, there is a strong association between SCC and presence of S. aureus. The study design used cannot determine whether the association implies that presence of S. aureus might influence carcinogenesis or whether it may imply that SCC has an increased susceptibility to S. aureus colonization. (Cancer Epidemiol Biomarkers Prev 2009;18(2):472 -8)

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Section: Introductionmentioning

confidence: 99%

Staphylococcus aureusand Squamous Cell Carcinoma of the Skin

Kullander

Forslund

Dillner

2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…These patients are highly susceptible to HPV infections (Kremsdorf et al, 1984;Orth et al, 1978), predominantly HPV-5 and -8, which belong to the genus Betapapillomavirus (Pfister, 2003;Pfister & Ter Schegget, 1997). These viruses are detectable both in skin cancers and in specimens of healthy skin from the general population (Antonsson et al, 2003a;Astori et al, 1998;Harwood & Proby, 2002), but a recent study has found that betapapillomaviruses of species 1 tend to be associated with benign skin lesions, whilst betapapillomaviruses of species 2 are more commonly found in skin cancers .…”

Section: Introductionmentioning

confidence: 99%

Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis

Vasiljević

Hazard

Dillner

et al. 2008

Journal of General Virology

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Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus Betapapillomavirus, and squamous cell carcinoma (SCC) of the skin. As most of these viruses are uncharacterized, molecular characterization and epidemiology are needed to advance our understanding of their significance in carcinogenesis. This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated , an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients by HPV type-specific real-time PCR assays. Seventeen patients (6.5 %) harboured at least one of the four HPV types in their lesion, whereas seven patients (2.7 %) harboured one or more of the HPV types in healthy skin. Overall, the four viruses were more common in AK than in healthy skin (odds ratio 5.0, 95 % confidence interval 1.4-17.5), but the prevalence and viral loads were low. This characterization of expands the heterogeneity of members of species 2 of the genus Betapapillomavirus. However, as these types were found in only a few samples and in low amounts, a possible role in carcinogenesis remains elusive.

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“…Sensitive detection techniques frequently identified EV-HPVs also in healthy skin and NMSC of the general population. They are particularly prevalent in immunosuppressed organ transplant recipients (6)(7)(8). The meaning of these findings for skin carcinogenesis is still uncertain because no single highrisk HPV types predominate in NMSC of non-EV patients and low viral loads suggest that only a minority of tumor cells contain HPV DNA (reviewed in ref.…”

Section: Introductionmentioning

confidence: 99%

Development of Skin Tumors in Mice Transgenic for Early Genes of Human Papillomavirus Type 8

et al. 2005

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The cutaneous human papillomavirus (HPV) 8 is clearly involved in skin cancer development in epidermodysplasia verruciformis patients and its early genes E2, E6, and E7 have been implicated in cell transformation in vitro. To examine the functions of these genes in vivo we integrated the complete early region of HPV8 into the genome of DBA/Bl6 mice. To target their expression to the basal layer of the squamous epithelia the transgenes were put under the control of the keratin-14 promoter. Transgenic mice were back-crossed for up to six generations into both FVB/N and Bl6 mouse strains. Whereas none of the HPV8 transgene-negative littermates developed lesions in the skin or any other organ, 91% of HPV8-transgenic mice developed single or multifocal benign tumors, characterized by papillomatosis, acanthosis, hyperkeratosis, and varying degrees of epidermal dysplasia. Squamous cell carcinomas developed in 6% of the transgenic FVB/N mice. Real-time reverse transcription-PCR showed highest expression levels for HPV8-E2, followed by E7 and E6. There was no consistent difference in relative viral RNA levels between healthy or dysplastic skin and malignant skin tumors. Whereas UV-induced mutations in the tumor suppressor gene p53 are frequently detected in human skin carcinomas, mutations in p53 were not observed either in the benign or malignant mouse tumors. Nonmelanoma skin cancer developed in HPV8-transgenic mice without any treatment with physical or chemical carcinogens. This is the first experimental proof of the carcinogenic potential of an epidermodysplasia verruciformis-associated HPV-type in vivo. (Cancer Res 2005; 65(4): 1394-400)

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Role of HPV in cutaneous premalignant and malignant tumors

Cited by 120 publications

References 83 publications

Staphylococcus aureusand Squamous Cell Carcinoma of the Skin

Staphylococcus aureusand Squamous Cell Carcinoma of the Skin

Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis

Development of Skin Tumors in Mice Transgenic for Early Genes of Human Papillomavirus Type 8

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