Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix

Delvenne, Philippe; Herman, Ludivine; Kholod, Natalia; Caberg, Jean-Hubert; Herfs, Michaël; Boniver, Jacques; Jacobs, Nathalie; Hubert, Pascale

doi:10.1016/j.mce.2006.10.014

Cited by 35 publications

(23 citation statements)

References 59 publications

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“…First, co-factors may promote HPV infection by causing cervical epithelial injury, such as: early age at first sexual activity and first delivery, multiple pregnancies and/or multiple sexual partners (Kahn et (Delvenne et al, 2007), leading to increased risk for cervical cancer in longer use of contraceptive in this study. Estrogen contained in oral contraceptives may affect cervical carcinogenesis in several ways, such as: increasing the S-phase fraction (Bhattacharya et al, 1997), increasing the sensitivity of cervical transformation zone (Hughes et al, 1988;Castellsague et al, 2003) and binding to a specific DNA sequences within transcriptional regulatory regions on the HPV DNA either to increase or to suppress transcription of various genes (Moodley et al, 2003).…”

Section: Discussionmentioning

confidence: 84%

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.97 (p<0.001) and an adjusted OR of 38.07 (p<0.001) were observed. Early age at first sexual exposure, and multiple sexual partners increased the risk of cervical cancer with ORs ranging between 1.73-2.78 (p<0.05). The interval between menarche and first sexual intercourse <6 years resulted in a significant increase in the risk for cervical cancer with ORs ranging between 3.32-4.09 and the respective adjusted OR range for the 4-5 and 2-3 year-old groups were 4.09 and 2.92. A higher risk was observed among subjects whose partner had smoking habits, whether currently or formerly; with respective ORs of 3.36 (p<0.001) and 2.17 (p<0.05); and respective adjusted ORs of 2.90 (p<0.05) and 3.55 (p<0.05). Other smoking characteristics of the partners including smoking duration ≥ 20 years, number of cigarettes smokes ≥ 20 pack-years and exposure time of the subject to passive smoking ≥ 5 hrs per day were found to be statistically significant risks for cervical cancer with adjusted ORs of 3.75, 4.04 and 11.8, respectively. Our data suggest that the risk of cervical cancer in Thai women is substantially associated with smoking characteristics of the partner(s), the interval between menarche and first sexual intercourse as well as some other aspects of sexual behavior.

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Section: Discussionmentioning

confidence: 84%

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…High levels of sex hormones appear to be involved in cervical carcinogenesis: oestrogen has been suggested to stimulate HPV gene expression, influence the cervical immune response, and stimulate cell proliferation in the transformation zone (Delvenne et al , 2007; Gariglio et al , 2009). Exposure to sex hormones is related to both parity and OC use.…”

Section: Discussionmentioning

confidence: 99%

Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up

et al. 2012

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Background:Several environmental factors have been associated with increased risks for cervical cancer. We examined whether reproductive history, contraceptive use, or sexual behaviour increase the risk for cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among women with persistent human papillomavirus (HPV) infection.Methods:A population-based cohort of women participated in a personal interview and underwent a gynaecological examination at which cervical specimens were obtained for HPV DNA testing. Follow-up information (∼13 years) on cervical lesions was obtained from the Danish Pathology Data Bank. Women who had a high-risk HPV infection comprised the overall study population (n=1353). A subgroup of women with persistent high-risk HPV infection (n=312) was identified. Hazard ratios (HRs) for a diagnosis of CIN3+ and the corresponding 95% confidence intervals (CIs) were calculated.Results:Women with persistent HPV infection who had given birth had a significantly increased risk for CIN3+ (HR=1.78; 95% CI: 1.07–2.94). No association was found with pregnancy, use of intrauterine devices, or sexual behaviour. Based on small numbers, women with persistent HPV infection had a decreased risk for CIN3+ with any use of oral contraceptives (HR=0.54; 95% CI: 0.29–1.00).Conclusion:Childbirth increases the risk for subsequent CIN3+ among women with persistent HPV infection.

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“…It results from a metaplastic conversion of glandular epithelial cells into squamous epithelium in response to a repetitive hormone induce vaginal pH acidification and sexual intercourse injury. 33 This metaplastic process is often associated with local deregulation of cytokine and chemokine production as well as inflammatory response. Herfs et al 34 hypothesized that this could lead to the establishment of an immunosuppressive microenvironment and potentiate tumor cell progression to the underlying stroma.…”

Section: Discussionmentioning

confidence: 99%

Improved computer-assisted analysis of the global lymphatic network in human cervical tissues

et al. 2014

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Lymphatic dissemination is a key event in cervical cancer progression and related tumor lymphatic markers are viewed as promising prognostic factor of nodal extension. However, validating such parameters requires an objective characterization of the lymphatic vasculature. Here, we performed a global analysis of the lymphatic network using a new computerized method applied on whole uterine cervical digital images. Sixty-eight cases of cervical neoplasia (12 CIN3, 10 FIGO stage 1A and 46 stage IB1) and 10 cases of normal cervical tissue were reacted with antibodies raised against D2-40, D2-40/p16 and D2-40/Ki67. Immunostained structures were automatically detected on whole slides. The lymphatic vessel density (D2-40), proliferating lymphatic vessel density (D2-40/ki67) and spatial lymphatic distribution in respect to the adjacent epithelium were assessed from normal cervix to early cervical cancer and correlated with lymphovascular space invasion and lymph node status. Prominent lymphatic vessel density and proliferating lymphatic vessel density are detected under the transformation zone of benign cervix and no further increase is noted during cancer progression. Notably, a shift of lymphatic vessel distribution toward the neoplastic edges is detected. In IB1 cervical cancer, although intra-and peritumoral lymphatic vessel density are neither correlated with lymphovascular space invasion nor with lymph node metastasis, a specific spatial distribution with more lymphatic vessels in the vicinity of tumor edges is predictive of lymphatic dissemination. Herein, we provide a new computerized method suitable for an innovative detailed analysis of the lymphatic network. We show that the transformation zone of the benign cervix acts as a baseline lymphangiogenic niche before the initiation of neoplastic process. During cancer progression, this specific microenvironment is maintained with lymphatic vessels even in closer vicinity to tumor cells.

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Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix

Cited by 35 publications

References 59 publications

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up

Improved computer-assisted analysis of the global lymphatic network in human cervical tissues

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