Role of Homocysteine Metabolism in Cardiovascular Diseases

Kumar, Prashant; Verma, Sunil Kumar; Rai, Sweta; Prakash, Parvathy; Chitara, Dheeraj

doi:10.1007/978-981-16-6867-8_14

Cited by 5 publications

(1 citation statement)

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“…In addition to classic cardiovascular risk factors, there are additional cardiovascular risk factors such as homocysteine, C-reactive protein, fbrinogen, and lipoprotein (a) that may coexist in patients with hypertension [3][4][5]. Homocysteine levels in blood are regarded as an independent risk factor for cardiovascular and noncardiovascular death.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Consequences of Blood Pressure Management and Blood Homocysteine Levels with Perindopril in Newly Diagnosed Hypertensive Patients in the Vietnamese Population

Kim Tran,

Truong,

Nguyen

et al. 2023

International Journal of Hypertension

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Background. Perindopril is an ACE inhibitor that aids in both blood pressure regulation and homocysteine reduction. Objectives. Our study aimed to evaluate the results of controlling blood pressure and blood homocysteine levels by perindopril in patients with primary hypertension. Materials and Methods. A cross-sectional descriptive study with a longitudinal follow-up was conducted on 105 primary hypertensive patients treated with perindopril. Results. The results of our study showed that after 6 weeks of treatment with perindopril, the proportion of patients with the target blood pressure (BP) level accounted for 70.5%, the rate of grade 1 hypertension decreased from 61.0% to 25.7%, grade 2 blood pressure decreased from 17.1% to 3.8%, and there was no case of grade 3 hypertension. At the same time, we also found that the rate of BP control in the group of patients who controlled Hcy below a threshold of 15 μmol/L was significantly higher than in the other group p < 0.05 . Concerning the efficacy of decreasing homocysteine in blood, we discovered that after 6 weeks of treatment with perindopril, the proportion of patients with elevated homocysteine reduced considerably from 74.3% to 40% p < 0.05 . In addition, the homocysteine concentration was 4.33 mol/L lower after treatment than before treatment (95% CI: 3.69–4.97) p < 0.05 . Conclusion. Perindopril helps control blood pressure and reduces blood homocysteine levels in patients with primary hypertension.

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Section: Introductionmentioning

confidence: 99%