Role of HLA in IgA nephropathy

Kasahara, Masanori; Hamada, Koji; Okuyama, T; Ishikawa, Naoshi; Ogasawara, Kunio; Ikeda, Hitoshi; Takenouchi, Toshinao; Wakisaka, Akemi; Aizawa, Mamoru; Kataoka, Yoshimitsu; Miyamoto, Reiko; Kohara, Masaki; Naito, Setsuya; Kashiwagi, Noboru; Hiki, Yoshiyuki

doi:10.1016/0090-1229(82)90181-7

Cited by 18 publications

(9 citation statements)

References 16 publications

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“…In the past 2 decades, the association of HLA-DRB1 alleles and pIgAN has been studied in various ethnic groups [10,11,12,13,14]. In Japanese and French [19] cohorts, there was a strong association between pIgAN and the HLA-DR4 gene; a study of Japanese patients found that some haplotypes of the HLA-DRA locus had an important role in the development of pIgAN [30, 31].…”

Section: Resultsmentioning

confidence: 99%

“…In the past decades, there were many clinical studies which provided further evidence indicating a marked association of HLA gene polymorphism and pIgAN [2,3,4,5]. Earlier studies have shown that HLA-DR * 4 might be associated with pIgAN, especially in Japanese [10,11,12,13] and Chinese patients [14]. There is a significant association between HLA-DQB1 * 0301 and IgAN patients with a poor clinical outcome [15].…”

Section: Introductionmentioning

confidence: 99%

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Human Leukocyte Antigen <i>DRB1</i> Alleles Predict Risk and Disease Progression of Immunoglobulin A Nephropathy in Han Chinese

Cao

Nie

et al. 2008

Am J Nephrol

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The role of human leukocyte antigen (HLA) class II polymorphisms in the pathogenesis and progression of primary immunoglobulin A nephropathy (pIgAN) is unclear. This study aimed to explore the relationship of HLA-DRB1 alleles with the susceptibility and disease progression of pIgAN in Han Chinese. A PCR-based genotyping technique was used to detect HLA-DRB1 alleles in 139 patients with pIgAN and 143 healthy subjects. A total of 37 HLA-DRB1 alleles were detected, of which 30 were found in pIgAN patients and 29 in healthy subjects. In pIgAN patients, the frequencies of HLA-DRB1*140501 (belonging to DR*14) were significantly increased, while the frequencies of HLA-DRB1*070101 (belonging to DR*7) were significantly reduced compared with the healthy individuals. Further stratification analysis revealed that the frequencies of HLA-DRB1*030101 in pIgAN patients with normal renal function were significantly higher than those in patients with renal dysfunction. These findings suggest that HLA-DRB1 polymorphisms are related to the occurrence and disease progression of pIgAN patients in Han Chinese, with HLA-DRB1*140501 being a susceptible allele and HLA-DRB1*070101 a resistant allele. HLA-DRB1*030101 may serve as a predictor of disease progression and renal damage of pIgAN in Han Chinese. Further studies are warranted to explore the immunological mechanisms for the genotype-disease phenotype relationship.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human Leukocyte Antigen <i>DRB1</i> Alleles Predict Risk and Disease Progression of Immunoglobulin A Nephropathy in Han Chinese

Cao

Nie

et al. 2008

Am J Nephrol

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“…The association of HLA-DR4 with IgA nephropathy might be consistent in Caucasians [1] and Japanese [2][3][4][5], but several reports also exist on the association of HLABw35 with IgA nephropathy [1], Idiopathic membranous nephropathy was associated with HLA-DR3 in Cauca sians [6,7] but with DR2 in Japanese [8,9], So, there have still been some discrepancies among studies and races investigated. There have been reports on the association of specific HLA antigens with lipoid nephrosis and post streptococcal glomerulonephritis in Caucasians as well as in Japanese.…”

Section: Introductionmentioning

confidence: 99%

Association of Class II Antigens of HLA with Primary Glomerulopathies

Naito¹,

Kohara²,

Arakawa³

1987

Nephron

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HLA antigens of Japanese patients with primary glomerulopathies were determined, and the frequency of each HLA antigen was compared with that of Japanese normal controls. IgA nephropathy with HLA-DR4, idiopathic membraneous glomerulopathy with DR2, lipoid nephrosis with DRw53 and poststreptococcal glomerulonephritis with DR1 were definitely or probably associated. It was suggested that primary glomerulopathies might all be associated with HLA class II and not class I antigens. Japanese patients with HLA-Bw48 and -DRw8 were less susceptible to primary glomerulopathies.

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“…IgA nephropathy, on the other hand, has been shown to have an association with HLA-BW35 or HLA-B12, and more recently with HLA-DR4 [10]. Since HLA antigens are known to be associated with several immunopathological diseases, both IgA nephropathy and seronegative spondylarthropathies might be related to certain HLA complexes, but this requires confirmation by further systematic research work.…”

Section: Discussionmentioning

confidence: 95%

Case Report of IgA Nephropathy Associated with Ankylosing Spondylitis and HLA-B27

Saku¹,

Naito²,

Matsuzaki³

et al. 1987

Nephron

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A 32-year-old male patient with concurrent IgA neph ropathy and ankylosing spondylitis is described. He had HLA-B27 antigen. Renal involvement in seronegative spondylarthropathies is considered to be very rare. Eigh teen such cases reported are reviewed, and a possible common genetic or other pathogenesis discussed. Case ReportThe patient was a 32-year-old Japanese male who was admitted to hospital because of visual disturbance and mild headache. Posi tive physical findings on admission w'ere a blood pressure of 270/180 mm Hg, a tachycardia of 140 beats/min, grade IV retinopa thy, and scotoma of the left eye. Urinalysis revealed 70 -80 RBC/ HPF, a few hyaline casts and proteinuria of 3.0g/24 h. Laboratory studies revealed an elevated sedimentation rate (ESR) of 31 mm/h, BUN 22 mg/dl, serum creatinine 2.2 mg/dl, a 24-hour creatinine clearance of 36 ml/min and positive HLA-B27. Plasma renin activ ity was 5.7 ng/m l/h. Electrolytes and blood gases were within normal limits. The hematocrit was 36%, hemoglobin 12.2 g/d l with a normal WBC count and differential count. The platelet count was 223,000. Serum IgA concentration was 495 mg/dl which was higher than normal (120-450 m g/dl); the level of circulating immune com plexes was 1.3 pg/ml ( < 5 p/ml). Chest x-ray showed no pulmonary edema and cardiomegaly. The ECG revealed sinus tachycardia and left atrial enlargement. X-ray of sacroiliac joints and spine showed changes typical of ankylosing spondylitis.Malignant hypertension was diagnosed and the patient was rapidly treated, initially with nifedipine 30 mg/day, and then with captopril 100 m g/day; the diastolic blood pressure was controlled at approximately 80 mm Hg. The 24-hour creatinine clearance was between 30 and 40 ml/min. Aortography was performed; there was no evidence of aortitis or stenosis of renal arteries.A renal biopsy demonstrated mild mesangial proliferative glom erulonephritis with focal tubulointerstitial damage. There were three glomeruli of which two showed mild proliferation of mesan gial cell and matrix and one moderate mesangial proliferation. The glomerular basememt membranes were thin and smooth without shrinkage as is frequently seen in hypertensive patients. Focal tubular atrophy with mononuclear infiltrations was observed in the interstitium. Diffuse granular deposits of lgA(2 + ), C3( + ) and fibrinogen ( ± ) were found in the mesangium by immunofluores cence microscopy; (fig. I); deposits of IgG and Clq could not be identified.

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Role of HLA in IgA nephropathy

Cited by 18 publications

References 16 publications

Human Leukocyte Antigen <i>DRB1</i> Alleles Predict Risk and Disease Progression of Immunoglobulin A Nephropathy in Han Chinese

Human Leukocyte Antigen <i>DRB1</i> Alleles Predict Risk and Disease Progression of Immunoglobulin A Nephropathy in Han Chinese

Association of Class II Antigens of HLA with Primary Glomerulopathies

Case Report of IgA Nephropathy Associated with Ankylosing Spondylitis and HLA-B27

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