Role of HLA-B51 and HLA-B52 in susceptibility to pulmonary tuberculosis

Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

“…Therefore, the characterization of immune response genes is an important step in understanding the factors that can lead to TB and/or HIV-1, TB-HIV co-infected individuals, and IRIS onset. It is known that HLA (human leukocyte antigen) class I and KIR (killer-cell immunoglobulin-like receptor) genes influence the outcomes of HIV-1 infections and TB [5][6][7]. In particular, the HLA-B locus plays a dominant role in the selection of cytotoxic T-lymphocyte (CTL) responses when compared with other class I molecules [7][8][9].…”

Detection of Tuberculous Lymphadenopathy by Positron Emission Tomography/Computed Tomo­graphy in a Patient with Behçet’s Disease

“…Furthermore, HLA B51 antigen has been a well-known genetic factor, which plays a pivotal role in determining susceptibility of BD (9). Vijaya Lakshmi et al (10) reported that HLA B51 has a susceptible association for pulmonary tuberculosis, whereas HLA B52 has a protective association.…”

HLA profile in patients with AIDS and tuberculosis

“…Vijaya Lakshimi et al (2006) [8], in a study of the association of class I molecules (HLA-B) in patients with pulmonary tuberculosis who also had AIDS, or not, detected an association of HLA-B52(5) with protection against, and of HLA-B51(5) with susceptibility to tuberculosis, regardless of whether the patient was HIV-infected or not.…”

“…In addition, there is a relation between the immunological response and the HLA profile of an individual, which results in greater or lesser genetic susceptibility to certain infections, such as tuberculosis [2][3][4][5][6][7][8][9][10].…”