Role of histopathology in predicting type 1 lepra reaction in borderline tuberculoid leprosy

Sankaran, Dhanya; Sasidharanpillai, Sarita; Ajithkumar, Kidangazhiathmana; Aparna, Govindan; Seemi, Ekkila Valappil; Sathi, P P

doi:10.4103/idoj.idoj_423_19

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Immunity: The immunological status of an individual decides the probability of the occurrence of the leprosy disease. At the TT pole, there is strong cell-mediated immunity, very few bacilli, and localized lesions [ 25 ]. At the other pole, that is, the lepromatous one, there is a lack of cell-mediated immunity, a strong humoral response, disseminated disease, and a large no of bacilli [ 26 ].…”

Section: Reviewmentioning

confidence: 99%

Leprosy Classification, Clinical Features, Epidemiology, and Host Immunological Responses: Failure of Eradication in 2023

Alrehaili

2023

Cureus

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Leprosy is of big concern in the medical fraternity. Leprosy is also known as Hansen’s disease. It is a curable communicable disease that remains prevalent in most countries all over the globe. It is a chronic granulomatous infection commonly caused by Mycobacterium leprae and Mycobacterium lepromatosis , which mainly show an effect on the skin and peripheral nerves. To control the disease and minimize the impact of the disease, much effort has been put into it for decades. Nearly 0.2 million fresh cases were documented in 2017 worldwide in spite of being declared “eradicated” by the WHO in the year 2000. However, impressive achievements have been made in several countries, including India; still, we are lagging behind the ultimate goal of the final disappearance of leprosy. Extensive migration is a crucial element that may transmit leprosy to unaffected areas. Additionally, there are several areas in the USA where person-to-person leprosy transmission has been reported without a prior history of exposure. Recently, WHO instigated a new Global Leprosy Strategy 2021-2030, termed "Towards Zero Leprosy." In this article, we review the clinical features, leprosy epidemiology, transmission, classification, host immunological response, and diagnostic challenges.

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Section: Reviewmentioning

confidence: 99%

Leprosy Classification, Clinical Features, Epidemiology, and Host Immunological Responses: Failure of Eradication in 2023

Alrehaili

2023

Cureus

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“…Type 1 reactions can be improved (reversal reactions) or worsened (degradation reactions). In these cases, the common clinical manifestations are hyperesthesia, erythema, edema, subsequent scaling, and sometimes ulceration and neuritis [ 32 , 34 ]. Approximately 95% of type 1 reaction cases occur in the first 2 years after starting MDT [ 35 ].…”

Section: Leprosy Reactionsmentioning

confidence: 99%

Leprosy: A Review of Epidemiology, Clinical Diagnosis, and Management

Chen

Lin

et al. 2022

Journal of Tropical Medicine

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Leprosy is a neglected infectious disease caused by acid-fast bacillus Mycobacterium leprae. It primarily affects the skin and then progresses to a secondary stage, causing peripheral neuropathy with potential long-term disability along with stigma. Leprosy patients account for a significant proportion of the global disease burden. Previous efforts to improve diagnostic and therapeutic techniques have focused on leprosy in adults, whereas childhood leprosy has been relatively neglected. This review aims to update the diagnostic and therapeutic recommendations for adult and childhood leprosy. This review summarizes the clinical, bacteriological, and immunological approaches used in the diagnosis of leprosy. As strategies for the diagnosis and management of leprosy continue to develop better and more advanced knowledge, control and prevention of leprosy are crucial.

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Histopathology of the Skin in Leprosy

Massone,

Schettini

2022

Leprosy and Buruli Ulcer

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Role of histopathology in predicting type 1 lepra reaction in borderline tuberculoid leprosy

Cited by 5 publications

References 9 publications

Leprosy Classification, Clinical Features, Epidemiology, and Host Immunological Responses: Failure of Eradication in 2023

Leprosy Classification, Clinical Features, Epidemiology, and Host Immunological Responses: Failure of Eradication in 2023

Leprosy: A Review of Epidemiology, Clinical Diagnosis, and Management

Histopathology of the Skin in Leprosy

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