Role of histone demethylases and histone methyltransferases in triple-negative breast cancer: Epigenetic mnemonics

Mandumpala, Janice Jacson; Baby, Stephin; Tom, Antriya Annie; Godugu, Chandraiah; Shankaraiah, Nagula

doi:10.1016/j.lfs.2022.120321

Cited by 13 publications

(14 citation statements)

References 71 publications

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“…Histone methylation is related to transcriptional inhibition as well as transcriptional activation. For example, H3K4me2/3 ( 37 ), H3K36me1/3 ( 38 ), and H3K79me1/2 ( 39 ) are associated with transcriptional activation, and H3K27me2/3 ( 40 ) and H3K9me2/3 ( 41 ) are associated with transcriptional inhibition ( 42 ). Histone acetylation is regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) mediates the process of deacetylation.…”

Section: Transcriptional Regulation Of Macrophage Phenotype and Funct...mentioning

confidence: 99%

Transcriptional regulation of macrophages in heart failure

Wang

Sun

et al. 2023

Front. Cardiovasc. Med.

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Adverse cardiac remodeling after acute myocardial infarction is the most important pathological mechanism of heart failure and remains a major problem in clinical practice. Cardiac macrophages, derived from tissue resident macrophages and circulating monocyte, undergo significant phenotypic and functional changes following cardiac injury and play crucial roles in inflammatory response and tissue repair response. Currently, numerous studies indicate that epigenetic regulatory factors and transcription factors can regulate the transcription of inflammatory and reparative genes and timely conversion of inflammatory macrophages into reparative macrophages and then alleviate cardiac remodeling. Accordingly, targeting transcriptional regulation of macrophages may be a promising option for heart failure treatment. In this review, we not only summarize the origin and function of cardiac macrophages, but more importantly, describe the transcriptional regulation of macrophages in heart failure, aiming to provide a potential therapeutic target for heart failure.

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Section: Transcriptional Regulation Of Macrophage Phenotype and Funct...mentioning

confidence: 99%

Transcriptional regulation of macrophages in heart failure

Wang

Sun

et al. 2023

Front. Cardiovasc. Med.

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“…Poly(ADP-ribosyl)ation of TET1 regulates transcriptional TET1 expression [93]. In contrast to hypermethylation, TNBC is one of the most hypomethylated cancers [233]. TET1 DNA demethylase is notably overexpressed in roughly 40% of patients [234].…”

Section: Perspective and Conclusionmentioning

confidence: 99%

DNA Methylation Malleability and Dysregulation in Cancer Progression: Understanding the Role of PARP1

Srivastava

Lodhi

2022

Biomolecules

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Mammalian genomic DNA methylation represents a key epigenetic modification and its dynamic regulation that fine-tunes the gene expression of multiple pathways during development. It maintains the gene expression of one generation of cells; particularly, the mitotic inheritance of gene-expression patterns makes it the key governing mechanism of epigenetic change to the next generation of cells. Convincing evidence from recent discoveries suggests that the dynamic regulation of DNA methylation is accomplished by the enzymatic action of TET dioxygenase, which oxidizes the methyl group of cytosine and activates transcription. As a result of aberrant DNA modifications, genes are improperly activated or inhibited in the inappropriate cellular context, contributing to a plethora of inheritable diseases, including cancer. We outline recent advancements in understanding how DNA modifications contribute to tumor suppressor gene silencing or oncogenic-gene stimulation, as well as dysregulation of DNA methylation in cancer progression. In addition, we emphasize the function of PARP1 enzymatic activity or inhibition in the maintenance of DNA methylation dysregulation. In the context of cancer remediation, the impact of DNA methylation and PARP1 pharmacological inhibitors, and their relevance as a combination therapy are highlighted.

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“…Histone methylation modification is regulated by histone methyltransferases (HMTs) and histone demethylases (HDMs). According to different methylation sites and states, methylated histones can be activated (H3K4me2/3, H3K36me1/3, H3K79me1/2, and H4K20me1) or inhibit (H3K9me2/3, H3K27me2/3, H3K79me3, and H4K20me3) gene transcription ( 29 ). Similarly, another common acetylation modification is acetyltransferases (HATs) and deacetyltransferases (HDACs) that turn gene transcription on and off.…”

Section: Histone Modifications Regulate Endothelial-mesenchymal Trans...mentioning

confidence: 99%

Histone modification of endothelial-mesenchymal transition in cardiovascular diseases

Qiu

Zhong³

et al. 2022

Front. Cardiovasc. Med.

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Endothelial-mesenchymal transition (EndMT) is a differentiation process in which endothelial cells lose their own characteristics and acquire mesenchymal-like characteristics, which contributes to the formation and development of atherosclerotic plaques. Until now, there is still a lack of effective measures to treat atherosclerosis (AS), so there is an urgent need to understand the underlying mechanisms of AS. In addition, although various studies have shown that EndMT is involved in the pathological stages of cardiovascular diseases, such as myocardial fibrosis, myocardial hypertrophy, and hypertension, the specific molecular mechanisms driving EndMT are still in the exploratory stage. In this review, we review the role of histone modifications (methylation, demethylation and acetylation, deacetylation) on EndMT in cardiovascular disease, aiming to target histone-modifying enzymes to guide cardiovascular disease therapy.

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Role of histone demethylases and histone methyltransferases in triple-negative breast cancer: Epigenetic mnemonics

Cited by 13 publications

References 71 publications

Transcriptional regulation of macrophages in heart failure

Transcriptional regulation of macrophages in heart failure

DNA Methylation Malleability and Dysregulation in Cancer Progression: Understanding the Role of PARP1

Histone modification of endothelial-mesenchymal transition in cardiovascular diseases

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