Role of histamine and related substances in development of tolerance to edemagenic gases

Dixon, Joseph R.; Mountain, John T.

doi:10.1016/0041-008x(65)90134-1

Cited by 31 publications

(5 citation statements)

References 20 publications

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“…Ozone exposure. Mice were exposed for 4 h to either filtered air, 1 part/million (ppm) of O 3 , a level of exposure previously shown to induce neither pulmonary edema nor death in mice (8), or 3 ppm of O 3 . O 3 was generated by passing a constant flow of filtered, dry 100% oxygen through a high-voltage (7,000-V) discharge-device ultraviolet source and mixing it with a diluting flow of filtered room air (50 l/min) in a stainless steel and Plexiglas exposure chamber (100 liters) maintained at a net negative static pressure of 0.5 in.…”

Section: Animalsmentioning

confidence: 99%

Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice

Noviski

Brewer

Skornik

et al. 1999

Journal of Applied Physiology

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Exposure to ambient ozone (O3) is associated with increased exacerbations of asthma. We sought to determine whether mast cell degranulation is induced by in vivo exposure to O3 in mice and whether mast cells play an essential role in the development of pulmonary pathophysiological alterations induced by O3. For this we exposed mast cell-deficient WBB6F1-kitW/kitW-v (kitW/kitW-v) mice and the congenic normal WBB6F1 (+/+) mice to air or to 1 or 3 parts/million O3 for 4 h and studied them at different intervals from 4 to 72 h later. We found evidence of O3-induced cutaneous, as well as bronchial, mast cell degranulation. Polymorphonuclear cell influx into the pulmonary parenchyma was observed after exposure to 1 part/milllion O3 only in mice that possessed mast cells. Airway hyperresponsiveness to intravenous methacholine measured in vivo under pentobarbital anesthesia was observed in both kitW/kitW-v and +/+ mice after exposure to O3. Thus, although mast cells are activated in vivo by O3 and participate in O3-induced polymorphonuclear cell infiltration into the pulmonary parenchyma, they do not participate detectably in the development of O3-induced airway hyperresponsiveness in mice.

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Section: Animalsmentioning

confidence: 99%

Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice

Noviski

Brewer

Skornik

et al. 1999

Journal of Applied Physiology

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“…This is supported by the finding that plasma histamine and LDH3 are not significantly changed. A decrease in histamine has been demonstrated in the lungs of mice and rats exposed to oxidants (16)(17)(18), whereas increased levels of plasma LDH3 are suggested to be indicative of lung tissue damage (19).…”

Section: Methodsmentioning

confidence: 99%

“…Cages were placed in a stainless steel cabinet. The animals had full access to water, but they were deprived of food for 16 hr prior to and in the penod of 03 exposure. 03 was generated by an adjustable silent-discharge ozonizer (Air-cos Switzerland) situated at the bottom of the cabinet.…”

Section: Methodsmentioning

confidence: 99%

Distinct Enzymatic Responses in Mice Exposed to a Range of Low Doses of Ozone

Veninga¹,

Wagenaar²,

Lemstra³

1981

Environmental Health Perspectives

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Short-term exposure of mice to low 03 doses, as defined by the product of concentration and exposure time (ct), was observed to induce alterations in two enzyme systems: first, that leading to changes in hepatic reduced ascorbic acid (RAA) content, and second to changes in plasma creatine phosphokinase (CPK) activity. RAA alterations were noticed immediately, 30 min and 120 min after termination of the exposure period, whereas CPK showed alterations immediately and 15 min after termination of the exposure. Later determinations, i.e., 24 hr after 03 exposure for RAA and 30 min after 03 exposure for CPK, revealed no significant differences when compared to control animals. Although differences in sensitivity existed, the dose response curves for both systems were more or less similar, showing a short decrease for the initial very low 03 doses, followed by a profound rise and a gradual decrease to control levels for subsequent ct doses. Exceptions were the 30 min curve for RAA and the immediate curve for CPK in so far as that both showed an additional depression.Neither plasma histamine nor plasma lactic acid dehydrogenase (LDH3) were observed to be altered by the range of 03 doses employed. These findings were explained on the basis of adaptation of the organism to a potentially noxious 03 stimulus by enhanced metabolic processes: a weak stimulus leading to only a small adjustment, and stronger stimuli to elevated enzyme activity as well. With increasing doses of 03 this elevation in enzyme activity was found to be gradually diminished, possibly due to a steadily growing demand, leaving the overshoot becoming continually smaller until a balanced state is achieved.Radiomimetic activity of ozone (03), first described by Brinkman and Lamberst (1) (5, 6). In the opinion of these authors there is no threshold value (no-effect level), and the dose-effect curve starts at zero. However, in the same way as with ionizing irradiation, in order to visualize effects, dosages of 03 have to be explored which in general clearly exceed the permissible

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“…If these cells are not removed from the pulmonary vascular compartment and the airspace then there is a great liklihood of masking the true response to a given edematogenic agent. We believe that the lack of perfusion coupled with varying degrees of edema has most likely been a major factor in contributing to the data conflict (1,16,17,18) regarding the effects of edematogenic agents on histamine and serotonin content of the lungs.…”

mentioning

confidence: 94%

Effects of Pulmonary Irritants on DNA, ATPase Activity, and Histamine on Rat Lung

Cronin¹,

Giri²

1974

Experimental Biology and Medicine

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Role of histamine and related substances in development of tolerance to edemagenic gases

Cited by 31 publications

References 20 publications

Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice

Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice

Distinct Enzymatic Responses in Mice Exposed to a Range of Low Doses of Ozone

Effects of Pulmonary Irritants on DNA, ATPase Activity, and Histamine on Rat Lung

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