Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice

Silva, Regina H.; Abı́lio, Vanessa C.; Takatsu, Akihiro; Kameda, Sonia R.; Grassl, Christian; Chehin, A.B.; Medrano, Wladimir Agostini; Calzavara, Mariana Bendlin; Registro, Sibele; Andersen, Mônica Levy; Machado, Ricardo Borges; Carvalho, Reinaldo de Amorim; Ribeiro, R. de A.; Tufik, Sérgio; Frussa‐Filho, Roberto

doi:10.1016/j.neuropharm.2003.11.032

Cited by 266 publications

(156 citation statements)

References 51 publications

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“…We have recently used the RSR paradigm to demonstrate that rats allowed to sleep for only 4 h per day for 8 consecutive days have increased basal corticosterone levels and develop pronounced changes in the reactivity of the hypothalamo-pituitary-adrenal axis to stress (18). RSR and other forms of SD have also been shown to alter regulation of corticosterone (18)(19)(20) and proinflammatory cytokine levels (21,22), elevate markers of oxidative stress (23), and promote neurodegenerative processes in the hippocampus (24,25).…”

Section: Discussionmentioning

confidence: 99%

Repeated sleep restriction in rats leads to homeostatic and allostatic responses during recovery sleep

Kim

Laposky

Bergmann

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

112

108

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Recent studies indicate that chronic sleep restriction can have negative consequences for brain function and peripheral physiology and can contribute to the allostatic load throughout the body. Interestingly, few studies have examined how the sleep-wake system itself responds to repeated sleep restriction. In this study, rats were subjected to a sleep-restriction protocol consisting of 20 h of sleep deprivation (SD) followed by a 4-h sleep opportunity each day for 5 consecutive days. In response to the first 20-h SD block on day 1, animals responded during the 4-h sleep opportunity with enhanced sleep intensity [i.e., nonrapid eye movement (NREM) delta power] and increased rapid eye movement sleep time compared with baseline. This sleep pattern is indicative of a homeostatic response to acute sleep loss. Remarkably, after the 20-h SD blocks on days 2-5, animals failed to exhibit a compensatory NREM delta power response during the 4-h sleep opportunities and failed to increase NREM and rapid eye movement sleep times, despite accumulating a sleep debt each consecutive day. After losing Ϸ35 h of sleep over 5 days of sleep restriction, animals regained virtually none of their lost sleep, even during a full 3-day recovery period. These data demonstrate that the compensatory/ homeostatic sleep response to acute SD does not generalize to conditions of chronic partial sleep loss. We propose that the change in sleep-wake regulation in the context of repeated sleep restriction reflects an allostatic process, and that the allostatic load produced by SD has direct effects on the sleep-wake regulatory system. allostasis ͉ homeostasis ͉ sleep deprivation ͉ stress ͉ rodents

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Section: Discussionmentioning

confidence: 99%

Repeated sleep restriction in rats leads to homeostatic and allostatic responses during recovery sleep

Kim

Laposky

Bergmann

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

112

108

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“…In this procedure, animals are aroused from sleep when the loss of muscle tone leads them to fall off the platform. This method produces a consistent amount of sleep reduction in mice (47).…”

Section: Animalsmentioning

confidence: 97%

Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus

Palma

Gabriel²,

Colugnati³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Firstly, PS following the acquisition of learning tasks leads to increases in the number and duration of episodes and PS density (Smith and Wong 1991). Secondly, many studies report an impaired acquisition when PSD is performed before or after the training period for several learning tasks (Smith 1985, Silva et al 2004a. PSD performed before the training period resulted in acquisition deficits that were not task-specific.…”

Section: Cognitionmentioning

confidence: 99%

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

Tufik

Andersen

Bittencourt

et al. 2009

An. Acad. Bras. Ciênc.

139

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Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.

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Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice

Cited by 266 publications

References 51 publications

Repeated sleep restriction in rats leads to homeostatic and allostatic responses during recovery sleep

Repeated sleep restriction in rats leads to homeostatic and allostatic responses during recovery sleep

Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

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