Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer

Abstract

The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was determined by performing immunohistochemistry on surgical tissue samples of 273 BC specimens from the Second Affiliated Hospital of Zhejiang University (Zhejiang, China) and 310 BCs from the National Engineering Center for Biochip (Shanghai, China). Kaplan-Meier analysis and Cox proportional hazard model were employed to analyze the survivability. HMGA1 expression was significantly associated with tumor histological degree and body mass index (BMI). However, HMGA1 expression showed no prognostic value in patients with BC. Combined evaluation of HMGA1 expression and high BMI (≥24 kg/m2) predicted worse overall survival of BC. Therefore, HMGA1 and BMI were considered to serve synergistic roles in the development and progression of BC, and combined evaluation of HMGA1 expression and high BMI may be an effective marker in predicting poor prognosis of BC patients.

HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas

“…A collection of studies recently demonstrated that high mobility group AT-hook 1 (HMGA1), which acts as a tumor promoter, is associated with several types of human cancers, including non-small cell lung cancer [ 5 ], breast cancer [ 6 ], and cervical cancer [ 7 ]. Recent studies have suggested the important roles of HMGA1 in gliomas.…”

Prevalence and Risk Factors of Type 2 Diabetes and Prediabetes Among 53,288 Middle-Aged and Elderly Adults in China: A Cross-Sectional Study

“…High BMI has been reported to be one of the strongest determinants of T2DM. 27 Compared with other European and American nations, Chinese participants had a higher comparative risk of T2DM than participants of other ethnic groups, despite having the same BMI. 28 The present study found that hypertension, hyperlipidemia, CHD, and stroke were positively related to T2DM, consistent with previous studies.…”

Long noncoding RNA LINC00963 promotes breast cancer progression by functioning as a molecular sponge for microRNA-625 and thereby upregulating HMGA1

“…HMGA1, a member of the HMGA protein family, regulates chromatin structure by directly binding to the A/T-rich DNA sequences located in the promoter and enhancer regions of multiple human genes [42]. HMGA1 exerts a crucial effect on the malignancy of breast cancer and is implicated in the regulation of various malignant characteristics [43][44][45]. Our current study revealed that the depletion of LINC00963 restrains the aggressiveness of breast cancer cells in vitro and in vivo; these influences turned out to be mediated by decreased sponging of miR-625 and consequent HMGA1 upregulation.…”