Role of Herbal Medicines in the Management of Brain Injury

Safdari, Mohammad; Shakeri, Farzaneh; Mohammadi, Ameneh; Bibak, Bahram; Alesheikh, Peiman; Jamialahmadi, Tannaz; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1007/978-3-030-73234-9_19

Cited by 8 publications

(8 citation statements)

References 109 publications

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“…Among the known antioxidants of Ziziphus spina-christi leaf extract are glycosides, phenols, terpenoids, cyclopeptide alkaloids, and flavonoids (Elghaffar et al, 2022;Sakna et al, 2019). In addition, consumption of the leaf extract has been shown to reduce oxidative stress and improve recovery from brain injury via modulatingaquaporin-4 and TLR4/NF-ĸB/TNF-α signaling pathways (Safdari et al, 2021). Using a rat animal model, Ziziphus spina-christi leaf extract has been reported to attenuate mercuric chloride-induced liver and testicular injury via normalizing oxidative stress (Almeer et al, 2020;Ramadan et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

JJBS

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Study areas include cell biology, genomics, microbiology, immunology, molecular biology, biochemistry, embryology, immunogenetics, cell and tissue culture, molecular ecology, genetic engineering and biological engineering, bioremediation and biodegradation, bioinformatics, biotechnology regulations, gene therapy, organismal biology, microbial and environmental biotechnology, marine sciences. The JJBS welcomes the submission of manuscript that meets the general criteria of significance and academic excellence. All articles published in JJBS are peerreviewed. Papers will be published approximately one to two months after acceptance.

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Section: Discussionmentioning

confidence: 99%

Untitled

2023

JJBS

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“…Furthermore, it increased brain ATP content, total adenine nucleotides, energy load, and Na+ K+ ATPase activity. It also improves the brain content of GPx, malondialdehyde (MDA), catalase, SOD and reduces the activity of the LOX enzyme, which, in turn, decreases lipid peroxidation [151][152][153][154].…”

Section: Bm Oxidative Stress Mithocondrial Dysfunction and Apoptosismentioning

confidence: 99%

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Valotto Neto,

Reverete de Araujo,

Moretti Junior

et al. 2024

Antioxidants

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The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has been conducted on the therapeutic applications of BM in neurodegenerative conditions. This systematic review aims to project BM’s beneficial role in brain disorders. BM has anti-apoptotic and antioxidant actions and can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, and increase neuroprotection. The included twenty-two clinical trials demonstrated that BM can reduce Nuclear Factor-κB phosphorylation, improve emotional function, cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, and psychiatric problems. Moreover, BM can reduce the levels of pro-inflammatory biomarkers and oxidative stress. Here, we highlight that BM provides notable therapeutic benefits and can serve as a complementary approach for the care of patients with neurodegenerative conditions associated with brain disorders. This review adds to the growing interest in natural products and their potential therapeutic applications by improving our understanding of the mechanisms underlying cognitive function and neurodegeneration and informing the development of new therapeutic strategies for neurodegenerative diseases.

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“…A HIF-1α inhibitor (YC-1) significantly reduced NLRP3 inflammasome, resulting in the downregulation of cell apoptosis and pyroptosis ( Jiang et al, 2020 ). Curcumin can also inhibit HIF-1α to alleviate brain injury by decreasing inflammation and TLR4/NF-κB/TNF-α and NO expression ( Safdari et al, 2021 ). It can thus potentially regulate HIF-1α expression to influence NLRP3 and autophagy in ischemic stroke.…”

Section: Curcumin Exerts Neuroprotection In Ischemic Stroke By Suppre...mentioning

confidence: 99%

Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke

Du,

Amin,

et al. 2023

Front. Pharmacol.

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Ischemic-induced neuronal injury arises due to low oxygen/nutrient levels and an inflammatory response that exacerbates neuronal loss. NOD-like receptor family pyrin domain-containing 3 (NLRP3) is an important regulator of inflammation after ischemic stroke, with its inhibition being involved in nerve regeneration. Curcumin, a main active ingredient in Chinese herbs, plays a positive role in neuronal repair and neuroprotection by regulating the NLRP3 signaling pathway. Nevertheless, the signaling mechanisms relating to how curcumin regulates NLRP3 inflammasome in inflammation and neural restoration following ischemic stroke are unknown. In this report, we summarize the main biological functions of the NLRP3 inflammasome along with the neuroprotective effects and underlying mechanisms of curcumin via impairment of the NLRP3 pathway in ischemic brain injury. We also discuss the role of medicinal interventions that target the NLRP3 and potential pathways, as well as possible directions for curcumin therapy to penetrate the blood–brain barrier (BBB) and hinder inflammation in ischemic stroke. This report conclusively demonstrates that curcumin has neuroprotective properties that inhibit inflammation and prevent nerve cell loss, thereby delaying the progression of ischemic brain damage.

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Role of Herbal Medicines in the Management of Brain Injury

Cited by 8 publications

References 109 publications

Untitled

Untitled

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke

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