Role of heparin-binding protein and brachial artery reactivity as prognostic tests in critically ill patients with sepsis

Ibrahim, Hanan; Ragab, Mohamed; Rizk, Fatima; Abbas, I. H.; Hagag, Talal I.M

doi:10.4103/1110-1415.198657

Cited by 1 publication

(3 citation statements)

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“…In the patient selection domain, 8 studies (28.5%) had a high risk of bias as their selection of patients may have introduced bias. [ 25 , 36 , 42 , 46 , 47 , 51 , 57 , 61 ] Furthermore, 2 studies (7.1%) had an unclear risk of bias because of insufficient information about their enrollment design. [ 37 , 55 ]…”

Section: Resultsmentioning

confidence: 99%

“…In the index test domain, 16 studies (58.6%) had a high risk of bias because of the lack of a prespecified cutoff threshold for HBP. [ 29 , 36 – 38 , 40 , 42 , 43 , 45 – 47 , 51 , 55 , 57 , 59 – 61 ] In the reference standard domain, 2 studies (7.1%) high risk of bias, [ 25 , 46 ] and the other 3 (10.7%) had unclear risk due to the interpretation bias. [ 53 , 55 , 61 ]…”

Section: Resultsmentioning

confidence: 99%

“…In the patient selection domain, 8 studies (28.5%) had a high risk of bias as their selection of patients may have introduced bias. [25,36,42,46,47,51,57,61] Furthermore, 2 studies (7.1%) had an unclear risk of bias because of insufficient information about their enrollment design. [37,55] In the index test domain, 16 studies (58.6%) had a high risk of bias because of the lack of a prespecified cutoff threshold for HBP.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

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Diagnostic and prognostic value of heparin-binding protein in sepsis: A systematic review and meta-analysis

Taha,

Najah,

Omar

et al. 2024

Medicine

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Background: Sepsis remains a leading cause of death worldwide. In this context, heparin-binding protein (HBP) has emerged as a possible biomarker, drawing significant attention for its diagnostic and prognostic usefulness in septic patients. Despite this advancement, the literature yields conflicting results. This study is intended to critically evaluate the diagnostic and prognostic value of HBP in critically ill septic patients. Methods: We searched multiple databases, including PubMed, SCOPUS, Web of Science, and EBSCO, to identify relevant studies on April 27, 2023. We included studies investigating sepsis or its severe outcomes that reported HBP levels and the required data to create 2 × 2 tables. We used R version 4.2.2 and R Studio to analyze the pooled diagnostic accuracy outcomes. The diagmeta package was utilized to calculate the optimum cutoff value. Results: In our meta-analysis, we incorporated 28 studies including 5508 patients. The analysis revealed that HBP has a sensitivity of 0.71 (95% CI: 0.60; 0.79) and a specificity of 0.68 (95% CI: 0.51; 0.81) in diagnosing sepsis, respectively. HBP demonstrated moderate prognostic accuracy for mortality at a cutoff value of 161.415 ng/mL, with a sensitivity and specificity of 72%, and for severe sepsis outcomes at a cutoff value of 58.907 ng/mL, with a sensitivity and specificity of 71%. Conclusion: Our findings indicate a relatively moderate diagnostic and prognostic accuracy of HBP for sepsis. Future studies are required to verify the accuracy of HBP as a biomarker for sepsis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…In the patient selection domain, 8 studies (28.5%) had a high risk of bias as their selection of patients may have introduced bias. [25,36,42,46,47,51,57,61] Furthermore, 2 studies (7.1%) had an unclear risk of bias because of insufficient information about their enrollment design. [37,55] In the index test domain, 16 studies (58.6%) had a high risk of bias because of the lack of a prespecified cutoff threshold for HBP.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

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