Role of heparin and non heparin binding serpins in coagulation and angiogenesis: A complex interplay

Bhakuni, Teena; Ali, Mohammad Farhan; Ahmad, Irshad; Bano, Shadabi; Ansari, Shoyab; Jairajpuri, Mohamad Aman

doi:10.1016/j.abb.2016.06.018

Cited by 56 publications

(36 citation statements)

References 148 publications

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“…22 Several signal pathways related to EC proliferation and differentiation are activated by VEGF. 23 bFGF, like VEGF, plays a role in differentiation of MSCs into ECs. 10 Previous research suggested that bFGF and VEGF have a synergistic angiogenic effect on the induction of angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Efficient Differentiation of Bone Marrow Mesenchymal Stem Cells into Endothelial Cells in Vitro

Wang

Yang

et al. 2018

European Journal of Vascular and Endovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Efficient Differentiation of Bone Marrow Mesenchymal Stem Cells into Endothelial Cells in Vitro

Wang

Yang

et al. 2018

European Journal of Vascular and Endovascular Surgery

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“…(B) Several factors of the intrinsic coagulation pathway (gray ovals) can be inhibited by either mosquito or tick serpins (yellow boxes, see Section 4.2). The mammalian serpins that target the same pathway are shown in comparison (blue boxes) [156–158]. (C) The evolutionary history of tick and mammalian thrombin-inhibiting serpins does not indicate any orthologies between individual tick and human serpin pairs.…”

Section: Figmentioning

confidence: 99%

Serpins in arthropod biology

Meekins

Kanost

Michel

2017

Seminars in Cell & Developmental Biology

142

136

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Serpins are the largest known family of serine proteinase inhibitors and perform a variety of physiological functions in arthropods. Herein, we review the field of serpins in arthropod biology, providing an overview of current knowledge and topics of interest. Serpins regulate insect innate immunity via inhibition of serine proteinase cascades that initiate immune responses such as melanization and antimicrobial peptide production. In addition, several serpins with anti-pathogen activity are expressed as acute-phase serpins in insects upon infection. Parasitoid wasps can downregulate host serpin expression to modulate the host immune system. In addition, examples of serpin activity in development and reproduction in Drosophila have also been discovered. Serpins also function in host-pathogen interactions beyond immunity as constituents of venom in parasitoid wasps and saliva of blood-feeding ticks and mosquitoes. These serpins have distinct effects on immunosuppression and anticoagulation and are of interest for vaccine development. Lastly, the known structures of arthropod serpins are discussed, which represent the serpin inhibitory mechanism and provide a detailed overview of the process.

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“…[1,3] With the exception of HA, which is nonsulfated and only exists as a major component of the ECM, GAGs are attached to cell surfaces and ECM protein cores to form proteoglycans. [2,6,7] Due to their unique position and high anionic character, GAGs modulate several important airway functions, including mucociliary clearance,[4] hydration and water homeostasis,[8,9] inflammation,[2,9,10] angiogenesis,[11] and tissue repair and remodeling of mucosal surfaces. [12] Moreover, accumulating evidence suggests that certain GAGs provide a protective mechanism against injury in asthma,[13,14] bronchitis,[15] chronic obstructive pulmonary disorder (COPD),[2,16,17] allergic rhinitis,[17] and chronic rhinosinusitis (CRS),[18] affording opportunities to develop new therapeutics for upper airway inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Prevention of sinonasal inflammation by a synthetic glycosaminoglycan

Pulsipher

Qin

Thomas

et al. 2016

Int Forum Allergy Rhinol

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Background Glycosaminoglycans (GAGs) are polysaccharides that are distributed on respiratory epithelial cells, endothelial cells, and submucosal glands. Uniquely positioned, certain GAGs exhibit anti-inflammatory properties in respiratory diseases and serve important roles in repairing mucosal surfaces and modulating mucociliary clearance. We hypothesized that topical administration of a synthetic GAG (GM-0111) would prevent sinonasal inflammation in a mouse model of rhinosinusitis (RS). Methods To test our hypothesis, C57BL/6 mice were intranasally administered fluorescent GM-0111, and sinonasal tissues were examined for coating and penetration ability. To test therapeutic feasibility, mice (n = 6) were given GM-0111 or hyaluronic acid (HA) (800 μg dose) prior to inducing RS with inflammatory molecule LL-37 (115 μg dose). After 24 h, sinonasal tissues were harvested for histological and biochemical analysis of inflammatory markers (inflammatory cell infiltration, lamina propria (LP) thickening, and neutrophil enzyme myeloperoxidase (MPO)) and cell death. Results (1) GM-0111 was observed within sinonasal tissues 1 h and 24 h after intranasal administration, indicating rapid and effective coating and penetration. (2) GM-0111 prevented sinonasal tissues from developing inflammatory changes, with significant reductions in mast cell infiltration (p < 0.05), LP thickening (p < 0.001), and MPO levels (p < 0.01) when compared to tissues treated with LL-37 and those pre-treated with HA. (3) GM-0111 reduced cell death within sinonasal tissues in contrast to LL-37-treated tissues. Conclusions We report a new synthetic GAG (GM-0111) that uniformly coats and penetrates into the sinonasal mucosa to prevent sinonasal inflammation and cell death in a mouse model of RS.

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Role of heparin and non heparin binding serpins in coagulation and angiogenesis: A complex interplay

Cited by 56 publications

References 148 publications

Efficient Differentiation of Bone Marrow Mesenchymal Stem Cells into Endothelial Cells in Vitro

Efficient Differentiation of Bone Marrow Mesenchymal Stem Cells into Endothelial Cells in Vitro

Serpins in arthropod biology

Prevention of sinonasal inflammation by a synthetic glycosaminoglycan

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