Role of Heparan Sulfate in Cancer

Liu, Dongfang; Sasisekharan, Ram

doi:10.1016/b978-008044859-6/50026-5

Cited by 5 publications

(4 citation statements)

References 166 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Applications of these species in other therapeutic areas, such as the major field of anticoagulation and thrombosis (Bourin and Lindahl, 1993; Linhardt, 2003) and the prospective ones in viral, Alzheimer's, and malaria diseases (Lindahl, 2007; Lindahl and Li, 2009) are outside the scope of this article. For HS and heparin relevant to inflammation and cancer, we choose to focus on paradigmatic examples rather than attempting to cover the expanding information relating to specific roles of HS, which are covered in other reviews (Linhardt, 2003; Götte, 2003; Iozzo, 2005; Whitelock and Iozzo, 2005; Liu and Sasisekharan, 2005; Gallagher, 2006; Fears and Woods, 2006; Taylor and Gallo, 2006; Bishop et al, 2007; Coombe, 2008; Rek et al, 2009; Fux et al, 2009; Iozzo et al, 2009; Lindahl and Li, 2009). …”

Section: Introductionmentioning

confidence: 99%

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

2010

View full text Add to dashboard Cite

The heparan sulfate (HS) chains of heparan sulfate proteoglycans (HSPG) are "ubiquitous" components of the cell surface and the extracellular matrix (EC) and play important roles in the physiopathology of developmental and homeostatic processes. Most biological properties of HS are mediated by interactions with "heparin-binding proteins" and can be modulated by exogenous heparin species (unmodified heparin, low molecular weight heparins, shorter heparin oligosaccharides and various non-anticoagulant derivatives of different sizes). Heparin species can promote or inhibit HS activities to different extents depending, among other factors, on how closely their structure mimics the biologically active HS sequences. Heparin shares structural similarities with HS, but is richer in "fully sulfated" sequences (S domains) that are usually the strongest binders to heparin/HS-binding proteins. On the other hand, HS is usually richer in less sulfated, N-acetylated sequences (NA domains). Some of the functions of HS chains, such as that of activating proteins by favoring their dimerization, often require short S sequences separated by rather long NA sequences. The biological activities of these species cannot be simulated by heparin, unless this polysaccharide is appropriately chemically/enzymatically modified or biotechnologically engineered. This mini review covers some information and concepts concerning the interactions of HS chains with heparin-binding proteins and some of the approaches for modulating HS interactions relevant to inflammation and cancer. This is approached through a few illustrative examples, including the interaction of HS and heparinderived species with the chemokine IL-8, the growth factors FGF1 and FGF2, and the modulation of the activity of the enzyme heparanase by these species. Progresses in sequencing HS chains and reproducing them either by chemical synthesis or semi-synthesis, and in the elucidation of the 3D structure of oligosaccharide-protein complexes, are paving the way for rational approaches to the development of HS-inspired drugs in the field of inflammation and cancer, as well in other therapeutic fields.

show abstract

Section: Introductionmentioning

confidence: 99%

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

2010

View full text Add to dashboard Cite

show abstract

“…11,12 Complex structures of glycosylated cell receptors and their natural ligands, as well as the high number of receptor types on one cell are serious problems in their recognition and targeting by small molecules. Nevertheless, work has shown that saccharide moieties are necessary for their function 13 and directed interest to their recognition. 5,14 Beside extraordinary photophysical properties, porphyrins can also offer a hydrophobic pocket with binding sites suitable for saccharide recognition in aqueous media.…”

Section: Porphyrin Derivatives For Saccharide Recognitionmentioning

confidence: 99%

Design, Synthesis, Selective Recognition Properties and Targeted Drug Delivery Application

Králová¹,

Kejík²,

Břı́za³

et al. 2014

Handbook of Porphyrin Science

View full text Add to dashboard Cite

“…[62,63] Similarly, the presence of specific point mutations can be identified through the use of gold nanoparticles capable of monitoring changes in the binding patterns of any protein of interest. [64] Likewise, the versatility of quantum dots (QDs) makes them principal candidates for systems-based cancer detection, as they have already been utilized for imaging cells, [65,66] tracking signaling pathways, [67] identifying cell-cell interactions, [68] and detecting metastasis. [69] As with any new medical technology, the in vivo use of QDs for cancer detection requires monitoring for ethical, safety, and regulatory issues.…”

Section: Cancer Combination Therapeuticsmentioning

confidence: 99%

Multifunctional Nanoscale Platforms for Targeting of the Cancer Cell Immortality Spectrum

Soundararajan

Warnock

Sasisekharan

2010

Macromol. Rapid Commun.

Self Cite

View full text Add to dashboard Cite

In the post-genomic era, "omics" platforms and cancer systems biology are greatly advancing our knowledge of the molecular and cellular underpinnings of cancer. In this article, we begin by outlining the factors governing the development of cancer (tumorigenesis) and use this framework to motivate the need for systems-approaches to cancer diagnostics and therapeutics. We review recent efforts to tap into the remarkable potential of nanotechnology for (i) systems-surveillance (or "sensing") of the molecular signatures of tumorigenesis, and (ii) spatiotemporally-regulated delivery (or "targeting") of combination therapeutics to cancer cells. Specifically, we highlight the salient role of polymeric biomaterials and describe the physicochemical characteristics that render them attractive for the design of such nanoscale platforms. We conclude with discussions on the emerging role of macromolecular biophysics and computational nanotechnology in engineering spatiotemporally-regulated anti-cancer systems.

show abstract

Role of Heparan Sulfate in Cancer

Cited by 5 publications

References 166 publications

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

Design, Synthesis, Selective Recognition Properties and Targeted Drug Delivery Application

Multifunctional Nanoscale Platforms for Targeting of the Cancer Cell Immortality Spectrum

Contact Info

Product

Resources

About