Role of hemogram-derived ratios and systemic-Immune inflammation index in prediction of COVID-19 progression in Egyptian patients

Abstract

Background: Early detection of COVID-19 patients with potentially severe disease is crucial for predicting the disease's course and prioritizing medical resources, lowering overall disease mortality. Objectives: To explore the role of baseline hemogram-derived ratios and systemic-immune inflammation index (SII), in addition to C-reactive protein (CRP), in predicting COVID-19 severity and prognosis. Methods: In this retrospective study, data were collected from the medical records of 425 COVID-19 patients. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII, together with the CRP, were investigated and compared. Results: NLR, PLR, SII, and CRP increased significantly in severe cases and with ICU admission (p ≤ 0.001). But, in nonsurvivors, only NLR and CRP were significantly elevated (p<0.05). By interpreting area under the receiver operating characteristic curve (ROC-AUC), CRP and NLR were better predictors of disease severity (AUC: 0.7 for both), the need for ICU admission (AUC: 0.763 and 0.727, respectively), and in-hospital mortality (AUC: 0.812 and 0.75, respectively). SII was significantly associated with the risk of severe disease development (odds ratio (OR): 3.143; 95% confidence interval (

Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?

“… 9 - 11 Moreover, the red cell distribution width (RDW), the mean platelet volume (MPV), and the systemic immune-inflammation index (SII) have emerged as biomarkers of inflammation and disease activity in a variety of diseases. 11 - 14 …”

Relationship between Systemic Immune-inflammation Index and Mortality in Intensive Care Patients Diagnosed with Crimean-Congo Hemorrhagic Fever

“…Recent studies showed that SIII might be used for the predictions of the prognosis and mortality in patients with cancer, coronary artery disease, hip fractures and Covid-19 patients. [8][9][10][11][12][13] The common feature of these conditions is inflammation but there is no study published in the literature focused on SIII in CCHF which is also an inflammatory disease. This study is unique in this respect.…”