Role of Hemoglobin and Serum Iron in Oral Submucous Fibrosis: A Clinical Study

Hegde, Karthik; Nair, Preeti P; Gharote, Harshkant; Agarwal, Krishna; Bhat, Guruprasad R; Rajaram, Divyashree Kalyanpur

doi:10.1100/2012/254013

Cited by 23 publications

(17 citation statements)

References 16 publications

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“…The proportion of this disease is more in male in our study which is in correlation with studies done in neighbouring countries 6,[13][14][15][16] with similar life style and culture. This difference is probably due to more outdoor activities in male and more accessibility of preparations.…”

Section: Discussionsupporting

confidence: 80%

Clinical profile and oral sub mucous fibrosis

Bhatta

Pyakurel

2017

Nepalese J ENT Head Neck Surg

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Objectives: Oral submucous fibrosis (OSMF) is an insidious precancerous disease mostly seen in the Southeast Asia. This paper aims to study on clinical profile of patients with OSMFMaterial and Methods: This cross sectional study was done in department of ENT and HNS, Nepalgunj Medical College and Teaching Hospital. In outpatient department patients with OSMF were ask to fill up a questionnaire that included identification of patient, occupation, their symptoms and habit of taking betel quid or paan, gutkha, etc. Oral cavity was examined and lesion along with its extent and severity was noted. Intra lesional steroid and antioxidant and physiotherapy were main stay of treatment.Results: There were total 136 patients (98 male and 38 female) from 15th Dec 2013 to 15th Jan 2015. Age of patient ranged from 16 years to 53 years and average being 25.6years. Most common preparation taken was gutkha 131(96.3%) followed by betel nut, betel quid etc. Only 24(17.6%) were taking these preparations for less than 1 year. Common presenting complaints were difficulty in opening mouth followed by burning sensation and dryness of mouth. Clinically, the extent of fibrous band was found to be more commonly involving soft palate, pillars and buccal mucosa. Isolated involvement of different region of oropharynx or oral cavity was less common. Correlation of grade of trismus and average duration of taking these different preparations was highly significant. (p=0.008)Conclusions: Oral submucous fibrosis is commonly associated with intake of gutkha having dose dependent relationship with trismus. Further studies are required why only a small fraction of those using betel quid develop the disease.

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Section: Discussionsupporting

confidence: 80%

Clinical profile and oral sub mucous fibrosis

Bhatta

Pyakurel

2017

Nepalese J ENT Head Neck Surg

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“…[21] OSMF patients showed significantly lower levels of both Hb and serum iron when compared with the healthy controls as the clinical stage of OSMF advances ( P < 0.0001). The study has similar results as present study [ P = 0.00001, Table 3].…”

Section: Discussionmentioning

confidence: 99%

Estimation of hemoglobin, serum iron, total iron-binding capacity and serum ferritin levels in oral submucous fibrosis: A clinicopathological study

Thakur

Guttikonda

2017

J Oral Maxillofac Pathol

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Introduction:Oral submucous fibrosis (OSMF) is also considered as an Asian version of sideropenic dysphagia, wherein chronic iron deficiency leads to mucosal susceptibility to irritants, such as chillies and areca nut products. Hemoglobin (Hb) levels, in particular, serum iron levels, are considered as biochemical indicators for nutritional assessment. Serum iron content can thus be a predictor for the progression of the condition, and there appears to be an association between serum iron content and oral carcinogenesis. Therefore, biochemical assessment of oral precancerous conditions may help in early diagnosis and prognosis. Hence, the present study was aimed to evaluate Hb, serum iron, total iron-binding capacity (TIBC) and serum ferritin in OSMF patients.Materials and Methods:Forty cases of OSMF were staged clinically and graded histopathologically to assess the levels of Hb, serum iron, TIBC and serum ferritin and compared with normal subjects. The results were compared using t-test, ANOVA, and Tukeys multiple post hoc procedures.Results:It was observed that the levels of Hb, serum iron and serum ferritin levels gradually reduced in OSMF patients compared with controls and as the clinical stage and histological grade of OSMF progressed with a statistically significant P < 0.05. It was observed that the levels of TIBC gradually increased in OSMF patients compared with controls and as the clinical stage and histological grade of OSMF progressed with a statistically significant P < 0.05.Conclusion:The Hb, serum iron and serum ferritin levels in OSMF patients were reduced and TIBC increased as compared with controls and as the clinical stage and histological grade of OSMF advances indicating their role as a reliable biochemical indicator.

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“…This findings was in accordance with several studies. [2,[8][9][10]14,17,18,[28][29][30][31][32][33][34][35][36][37] In the present study and all the various above studies, the level of serum iron was significantly decreased in OSMF patients when compared to controls. This can be due to cytochrome oxidase, an iron dependent enzyme, is required for the normal maturation of the epithelium.…”

Section: Section: Dentistrymentioning

confidence: 69%

Estimation of Iron and Vitamin C Levels In Serum and Saliva: A Clinical and Biochemical Study In Oral Submucous Fibrosis Patients

Bhalerao¹,

Lohe²,

Bhowate³

2018

AIMDR

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Background: OSMF is a well-recognized, potentially malignant condition of the oral cavity. Monitoring the widespread consequences of OSMF requires interventions in at-risk persons ideally earlier the disease becomes aggressive. Iron and vitamin C have been widely studied in recent years to judge whether they have any modifying effects in the etiology of precancer and cancer. Aim of study was to evaluate levels of iron and vitamin C in serum and saliva in patients with OSMF. Methods: Study group comprised of 66 patients, out of which 22 cases of clinically diagnosed OSMF patients and 22 cases of betelnut habitual without OSMF and 22 cases of age and sex matched control healthy patients were recruited. Estimation of Iron by Ferrozine method and vitamin C by 2-4 dinitrophenylhydrazine method in serum and saliva was carried out by using Spectrophotometer. The statistical analysis was done. Results: Level of iron and vitamin C in serum and saliva was significantly decreased in OSMF patients when compared to betelnut habitual and controls group which were statistically significant. Conclusion: The present study, all the cases of OSMF showed decrease in iron and vitamin C levels which suggests that the iron and vitamin C plays an important role in the pathogenesis and progression of OSMF. In group II (Betel nut habituals without OSMF) patients showed decrease in iron and vitamin C levels which suggest that, betel nut quid with or without tobacco consumption may alter the serum and salivary levels of iron and vitamin C and plays an important role in the advancement of OSMF. Therefore regular monitoring of betel nut habituals should also be carried out because they are at higher risk of developing OSMF in future. Study indicates that saliva also may be used as a potential non-invasive diagnostic tool to evaluate the iron and vitamin C in OSMF patients. Estimation of iron and vitamin C in OSMF patients would help in management, in developing therapies based on the trace element expression.

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Role of Hemoglobin and Serum Iron in Oral Submucous Fibrosis: A Clinical Study

Cited by 23 publications

References 16 publications

Clinical profile and oral sub mucous fibrosis

Clinical profile and oral sub mucous fibrosis

Estimation of hemoglobin, serum iron, total iron-binding capacity and serum ferritin levels in oral submucous fibrosis: A clinicopathological study

Estimation of Iron and Vitamin C Levels In Serum and Saliva: A Clinical and Biochemical Study In Oral Submucous Fibrosis Patients

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