Role of Hematologic Scoring System in Early Diagnosis of Neonatal Septicemia

Khair, K B; Rahman, Mohammad Matiur; Sultana, Tuhin; Roy, Chandan Kumar; Rahman, Quddusur; Shahidullah, Mohammod; Ahmed, AN Nashimuddin

doi:10.3329/bsmmuj.v3i2.7053

Cited by 33 publications

(51 citation statements)

References 11 publications

(10 reference statements)

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“…[29][30][31][32] In present study, I/T ratio had the best performance over the other hematological parameters with sensitivity 93.3%, specificity 80%, PPV 82.4% NPV 92.3% in agreement with Chirico et al who found I/T ratio may reach a sensitivity of 90% and negative predictive value of 98%. 33 In contrast to Payasli et al who found that I/T ratio failed to reach an appropriate sensitivity and NPV in neonatal sepsis and Wojsyk et al who reported poor sensitivity for I/T ratio in the early diagnosis of neonatal sepsis (59%).…”

Section: Discussionsupporting

confidence: 79%

“…In contrast to Khair et al who concluded that a score >4 has a sensitivity of 100%, specificity of 60%, with PPV 26% and NPV 100 %. 29,34 CRP has been routinely investigated and used for the diagnosis and follow up of neonatal sepsis. However, Elevated CRP levels are present in infections, noninfectious inflammatory diseases, trauma, surgery, recent vaccination, various perinatal problems, burns and malignancies which may cause false positive result.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of polymorphonuclear leukocyte elastase levels in neonatal sepsis

Pessar

2016

Int J Res Med Sci

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Evaluation of polymorphonuclear leukocyte elastase levels in neonatal sepsis

Pessar

2016

Int J Res Med Sci

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“…The findings of the present study correlates with Gupta et al, 4 Nandy et al, 5 Sriram et al 6 Wilson et al (1974) observed male predominance because congenital anomalies of urinary tract are attributable to higher prevalence of congenital anomalies in males and hence risk of urinary tract infection. 7 In the present study, 56.6% culture positive cases were males and 43.4% were females with male: female ratio being 1.3:1.…”

Section: Discussionmentioning

confidence: 92%

Sepsis Screen Parameters as a Tool for Diagnosis of Neonatal Sepsis

Ali¹,

Ghodke²,

Deka³

2017

jemds

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BACKGROUNDInfections are a frequent and important cause of morbidity and mortality in the neonatal period. Neonatal sepsis is one of the leading causes of morbidity and mortality in India. It is probably responsible for 30-50% of the total neonatal deaths each year in developing countries. Early recognition, diagnosis and treatment of serious infection in neonates are essential because of the risk of permanent morbidity and mortality.Aims and Objectives of the study are to evaluate various haematological parameters singly, find out sensitivity and specificity of the various sepsis screen parameters in clinically suspected cases of neonatal septicaemia and to correlate them with blood culture. MATERIALS AND METHODSThe present study is an observational study of the haematologic profiles (screening parameters) of 130 neonates admitted in the neonatal care unit of our tertiary care hospital from January 2013 to June 2014. All neonates asymptomatic and symptomatic were subjected to sepsis screen parameters after taking the clinical history and all investigations were done before starting any antibiotics. RESULTSOut of total 130 cases, 60 (46.1%) were culture positive and 70 (53.9%) were culture negative. Amongst 60 culture positive cases, 38 (63.4%) were EOS whereas 22 (36.6%) were LOS. Amongst 70 culture negative cases, 24 (34.3%) were EOS whereas 46 (65.7%) were LOS. Overall there is male preponderance. Preterm babies outnumbered the term babies. CONCLUSIONEarly onset sepsis (early neonatal period) was more common than late onset sepsis. Gram-negative infection was more common, Klebsiella was the most common organism isolated. C-reactive protein had highest sensitivity among all. Micro-ESR had highest specificity. All the tests employed using haematological profile can be performed easily at the primary health care centre level and results can be obtained in an hour.

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“…17 As males have only one X chromosome, male neonates may be more susceptible to infection than female neonates. 5,18 The IT ratio is the ratio of immature neutrophils to total neutrophils (mature and immature neutrophils) calculated from peripheral blood smear preparations. An IT ratio equal to or greater than 0.2 is considered to be abnormal.…”

Section: Discussionmentioning

confidence: 99%

A comparison of neutrophil gelatinase-associated lipocalin and immature to total neutrophil ratio for diagnosing early-onset neonatal sepsis

Wilar

Daud

As’ad

et al. 2016

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Background Neonatal sepsis is a clinical syndrome caused by the invasion of microorganisms into the bloodstream. Early diagnosis of early-onset neonatal sepsis (EONS) is difficult. Laboratory tests with high sensitivity and specificity are needed in order to make early diagnoses in newborns. Objective To compare the sensitivity and specificity of neutrophil gelatinase-associated lipocalin (NGAL) and immature to total (IT) neutrophil ratio for the diagnosis of early-onset neonatal sepsis. Methods This observational study with cross-sectional design was conducted in the Neonatology Division, Prof. R. D. Kandou General Hospital from November 2012 to April 2014. Consecutive sampling was applied. There were 103 newborns with suspected EONS who fulfilled the inclusion criteria. Complete blood counts, blood cultures, as well as NGAL and IT ratio measurements were performed. Results NGAL was not significantly more sensitive than IT ratio [80.4% vs. 67.3%, respectively; (P=0.058)]. However, NGAL had lower specificity than IT ratio (27.7% vs. 50.0%, respectively; P=0.016). The positive predictive values (57.0% vs. 64.9%, respectively; P=0.176), and negative predictive values (54.2% vs. 52.6%, respectively; P=0.451) were similar in both diagnostic tests. Conclusion Immature to total neutrophil (IT) ratio has higher specificity compared to NGAL for early diagnosis of EONS. However, the difference in sensitivity between the two test is not statistically significant. [Paediatr Indones. 2016;56:107-10.].

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Role of Hematologic Scoring System in Early Diagnosis of Neonatal Septicemia

Cited by 33 publications

References 11 publications

Evaluation of polymorphonuclear leukocyte elastase levels in neonatal sepsis

Evaluation of polymorphonuclear leukocyte elastase levels in neonatal sepsis

Sepsis Screen Parameters as a Tool for Diagnosis of Neonatal Sepsis

A comparison of neutrophil gelatinase-associated lipocalin and immature to total neutrophil ratio for diagnosing early-onset neonatal sepsis

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