Role of helicobacter pylori infection in the incidence and clinical course of monoclonal gammopathy of undetermined significance

Malik, Azhar A.; Ganti, Apar Kishor; Potti, Anil; Levitt, Ralph; Hanley, James F.

doi:10.1111/j.1572-0241.2002.05668.x

Cited by 31 publications

(17 citation statements)

References 32 publications

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“…There was no clear association between radiation exposure and the disease progression of MGUS [10]. Furthermore, a previous study demonstrated that MGUS subjects had a high rate of Helicobacter pylori infection (68.4%) [11]. Epidemiological identification of the risk factors for MGUS may shed light on the pathogenesis of this monoclonal plasma cell disorder.…”

Section: Introductionmentioning

confidence: 95%

Prevalence of monoclonal gammopathy of undetermined significance in Thailand

Watanaboonyongcharoen

Nakorn

Rojnuckarin

et al. 2012

Int J Hematol

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Individuals with monoclonal gammopathy of undetermined significance (MGUS) develop multiple myeloma and related malignancies at the rate of 1% per year. Given differences in ethnicity, data on prevalence and risk factors of MGUS in Thai population will be helpful in understanding the pathogenesis of plasma cell disorders and designing an early cancer detection strategy. Subjects of 50 years or older were included. Demographic data and suspected risk factors were collected. Monoclonal proteins were detected using serum protein electrophoresis. Serum was obtained from 3,260 participants; 1,104 males (33.9%) and 2,156 females (66.1%). The median age was 57 years (range 50-93 years). Monoclonal proteins were detectable in 2.3% (95% confidence interval [CI] 1.8-2.8). M spikes were found in gamma- and beta-globulin regions in 50 (1.5%) and 25 (0.8%) subjects, respectively. The prevalence of MGUS in subjects 50-59, 60-69, and 70 years or older was 2.0% (41/1,975), 2.6% (22/851), and 2.8% (12/434), respectively. By multivariate analysis, MGUS was associated with living outside Bangkok (odds ratio 2.25, 95% CI 1.11-4.58). The overall prevalence of MGUS in the Thai population was 2.3%, which was lower than that in Western countries, but comparable to that in Japan.

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Section: Introductionmentioning

confidence: 95%

Prevalence of monoclonal gammopathy of undetermined significance in Thailand

Watanaboonyongcharoen

Nakorn

Rojnuckarin

et al. 2012

Int J Hematol

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“…Infection by H. pylori has been linked to monoclonal gammopathy of undetermined significance (MGUS) [8]. Chronic antigenic stimulation and genetic susceptibility predispose to MGUS [9], which affects less than 5% of the population [10], and may precede multiple myeloma, plasma cell leukemia, or MALT lymphoma [11].…”

Section: Approximately Half Of the World's Population Is Infected Bymentioning

confidence: 99%

Monoclonal Gammopathy of Undetermined Significance and Russell Body Formation in Helicobacter pylori Gastritis

et al. 2006

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This is the first report to demonstrate that upon infection with H. pylori, an impaired secretory capacity of plasma cells due to specific molecular changes can present as Russell body gastritis. The molecular findings question a pathogenetic link between Russell bodies and H. pylori, but suggest genetic alterations in the immunoglobulin locus as the possible cause for both MGUS and Russell body gastritis.

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“…Resolution of the gammopathy is observed in up to 30% of cases by eradicating the bacteria [257], a relationship confirmed by some authors [246,258] but not by others [215,259].…”

Section: Plasma Cell Dyscrasiasmentioning

confidence: 85%

Helicobacter pylori and Hematologic Diseases

Campuzano-Maya¹

2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

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Helicobacter pylori infection is the most common infection of the human species, with developing countries displaying a marked disadvantage in contrast to developing countries. While H. pylori infection is asymptomatic in most infected individuals, it is intimately related to malignant diseases of the stomach, such as gastric cancer and gastric MALT lymphoma, as well as benign diseases, for example chronic gastritis and duodenal and gastric peptic ulcers. Since the discovery that gastric mucosa could be colonized by bacteria, evidence of greater than 50 extragastric manifestations has been reported, linking H. pylori infection and the development of diseases associated with cardiology, dermatology, endocrinology, obstetrics and gynecology, hematology, pneumology, neurology, odontology, ophthalmology, otorhinolaryngology, and pediatrics. This chapter presents the extragastric manifestations of H. pylori infection expressed through hematologic diseases; particularly those included in the international consensus, and discusses guidelines for the management of H. pylori infection, such as iron deficiency, vitamin B 12 (cobalamin) deficiency, and immune thrombocytopenia. Other manifestations reviewed include immune neutropenia, antiphospholipid syndrome, and plasma cell dyscrasias, such us monoclonal gammopathy of undetermined significance, multiple myeloma, and Henoch-Schönlein purpura.

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Role of helicobacter pylori infection in the incidence and clinical course of monoclonal gammopathy of undetermined significance

Cited by 31 publications

References 32 publications

Prevalence of monoclonal gammopathy of undetermined significance in Thailand

Prevalence of monoclonal gammopathy of undetermined significance in Thailand

Monoclonal Gammopathy of Undetermined Significance and Russell Body Formation in Helicobacter pylori Gastritis

Helicobacter pylori and Hematologic Diseases

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