Role of Helicobacter Pylori in Pathogenesis of Upper Respiratory System Diseases

Kurtaran, Hanifi; Uyar, Mehtap Erkmen; Kasapoğlu, Benan; Türkay, Cansel; Yilmaz, Türker; Akçay, Ali; Kanbay, Mehmet

doi:10.1016/s0027-9684(15)31471-1

Cited by 35 publications

(30 citation statements)

References 56 publications

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“…Both H. pylori and various respiratory diseases are characterized by the release of proinflammatory cytokines and attraction of granulocytes as well as Band T-cell-mediated response, though a pathophysiological association has not been proven. Neither the role of genetic predisposition of the host nor the presence of virulence factors nor the impact of H. pylori eradication have been studied in detail and definitely need further evaluation [88][89][90]. In 2011 Ahmed, Azza M, Motawie, Ayat A, ElSahrigy, Sally A. F, Kantoush, Nagwa A, Abdel-Ghany, Somaya M., Abdel-Shakour and Usama studied about Helicobacter Pylori infection in Egyptian children with Bronchial Asthma.…”

Section: Initial Therapymentioning

confidence: 99%

The Study of Association between Helicobacter pylori (H. pylori) and Chronic Obstructive Pulmonary Disease (COPD)

Deerpaul¹

2014

J Pulm Respir Med

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Section: Initial Therapymentioning

confidence: 99%

The Study of Association between Helicobacter pylori (H. pylori) and Chronic Obstructive Pulmonary Disease (COPD)

Deerpaul¹

2014

J Pulm Respir Med

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“…2,3 Infeksi H. pylori mempunyai pengaruh GERD dapat berupa sekresi lower eresophageal sphincter (LES) relaxing cytotoxins, prostaglandin, dan nitrat oksida oleh H. pylori, terjadi sensitisasi vagal yang dapat menurunkan ambang transient lower esophageal sphincter relaxation (TLESR), terjadi peningkatan sekresi gastrin, keterlambatan pengosongan isi lambung, serta trauma langsung akibat sitotoksin yang dikeluarkan oleh H. pylori pada mukosa esofagus. 6,7 Mendeteksi infeksi H. pylori terbagi menjadi dua kelompok, invasif dan noninvasif. Tes invasif meliputi endoskopi dengan cara biopsi, kemudian dilakukan pemeriksaan histologi, aktivitas urease Campylobacter like organism (CLO) disertai kultur.…”

Section: -4unclassified

“…Hal ini merupakan patogenesis GERD, sehingga pada refluks laringofaring kemungkinan keluhan nyeri dada/heartburn akan lebih tinggi dibandingkan dengan penderita refluks laringofaring tanpa infeksi H. pylori. 2,6,7,16 Pada kedua kelompok penelitian pascaterapi didapatkan perbaikan keluhan serak serta rasa mengganjal di tenggorokan yang lebih baik bila dibandingkan dengan kelompok perlakuan kombinasi antibiotik dan lansoprazol, sedangkan perbaikan gejala refluks lainnya tidak ditemukan perbedaan.Secara keseluruhan, perbaikan gejala didapatkan lebih baik pada kelompok perlakuan pertama.…”

Section: 17unclassified

“…Hasilnya ternyata tidak terdapat perbedaan signifikan antara jenis kelainan anatomis laring dan status infeksi H. pylori. 6,7 Eritema/hiperemis laring bukan merupakan tanda patognomonis refluks laringofaring tetapi >50% penderita refluks laringofaring terdapat eritema/hiperemis. Beberapa faktor yang menjadi penyulit untuk penilaian eritema/hiperemis pada refluks laringofaring disebabkan oleh karena jenis endoskopi dan sumber cahaya yang digunakan.…”

Section: -3unclassified

“…Selain itu, sitokin yang dihasilkan sebagai respons inflamasi juga berperan pada kerusakan mukosa. 6,7 Skor STR pascaterapi pada kedua kelompok perlakuan tidak memperlihatkan perbedaan yang bermakna. Menurut Koufman dkk.…”

Section: -3unclassified

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Efektivitas Pemberian Antibiotik Disertai Lansoprazol pada Refluks Laringofaring dengan Infeksi Helicobacter pylori

Nurrokhmawati¹,

Madiadipoera²,

Anggraeni³

et al. 2012

mkb

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AbstrakRefluks laringofaring adalah aliran balik isi lambung ke daerah laringofaring dan dapat dipengaruhi oleh infeksi Helicobacter pylori. Regimen terapi untuk infeksi H. pylori terdiri atas proton pump inhibitor (PPI) dan dua jenis antibiotik yaitu amoksisilin dan klaritromisin. Peran PPI pada regimen ini masih diteliti. Dilakukan penelitian mengenai perbandingan efektivitas terapi antibiotik disertai PPI (lansoprazol) terhadap perbaikan gejala klinis dan kualitas hidup penderita refluks laringofaring dengan infeksi H. pylori. The Effectiveness of Antibiotics with Lansoprazole in the Treatment of Laryngopharyngeal Reflux with Helicobacter pylori Infection AbstractLaryngopharyngeal Reflux (LPR) is a reflux of gastric content to the laryngopharyngeal and influenced by Helicobacter pylori infection. The treatment of H. pylori infection consists of proton pump inhibitor and two kinds of antibiotics, i.e. amoxicillin and clarithromycin. The role of PPI is currently being studied. The objectives of the research were to compare the effectiveness of antibiotics regimen with and without lansoprazole in reducing the level of the severity and quality of life improvement in LPR patients with H. pylori infection. Twenty six subjects were divided into two groups; the first group received antibiotics with lansoprazole and the second group received antibiotics without lansoprazole. The research subjects were assessed using reflux symptom index (RSI) questionnaire and reflux finding score (RFS) while the assessment on the quality of life was performed using reflux qual short-form (RQS) questionnaire. These data were obtained at baseline and after 2 weeks of treatment. The method was randomized clinical trial with open label observation and the analysis was conducted using t and Mann Whitney tests. There was a significant improvement in the RSI post treatment in the first group (p=0.034). The difference in RFS was not significantly different statistically between both groups (p=0.169). The RQS was significantly better statistically in the first group (p=0.018). It is concluded that treatment regimen with claritromicin, amoxycillin and lansoprazole is more effective in the treatment of LPR associated with H. pylori infection compared to without lansoprazole. [MKB. 2012;44(4):224-32].

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Absence of <emph type="ital">Helicobacter pylori</emph> in Pediatric Adenoid Hyperplasia

Hussey

Woods²,

Harris³

et al. 2011

Arch Otolaryngol Head Neck Surg

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Role of Helicobacter Pylori in Pathogenesis of Upper Respiratory System Diseases

Cited by 35 publications

References 56 publications

The Study of Association between Helicobacter pylori (H. pylori) and Chronic Obstructive Pulmonary Disease (COPD)

The Study of Association between Helicobacter pylori (H. pylori) and Chronic Obstructive Pulmonary Disease (COPD)

Efektivitas Pemberian Antibiotik Disertai Lansoprazol pada Refluks Laringofaring dengan Infeksi Helicobacter pylori

Absence of <emph type="ital">Helicobacter pylori</emph> in Pediatric Adenoid Hyperplasia

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