Role of Helicobacter Pylori in Chronic Urticaria among Egyptian Patients with Dyspepsia: A case–control study

Mosbeh, Al-Sadat

doi:10.17352/2455-8605.000023

Cited by 3 publications

(11 citation statements)

References 23 publications

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“…We found that 70.9% of the cases and controls were females, while 29.1% of the cases and controls were males. Our findings were similar to Moesbehi et al, and other authors who explained that CU affects more females than males [ 3 , 4 , 9 , 19 ]. The reason could be explained by low levels of dehydroepiandrosterone (DHEA)-S in females, suggesting a possible role for hormone imbalance with CU [ 3 , 4 ].…”

Section: Discussionsupporting

confidence: 93%

“…pylori infection while in controls it was 10.1%. The findings of this study were similar to the studies done in Egypt and Iraq [ 3 , 9 , 15 ], which explain that H . pylori infection is more in CU patients than in the controls.…”

Section: Discussionsupporting

confidence: 92%

“…The majority were aged from 20 to 29 years in both cases and controls, and there was no significant association between CU and baseline characteristics of the participants. Our findings were similar to Muhemmed and Khalis Mohammed, Alfahaad, Moesbehi et al, Majeed, and Jwan Saleh Khoshnaw [ 3 , 4 , 9 ] which explain that CU occurs mostly in adults. Our findings concur with the literature that CU is related to frequent, long duration, and prolonged exposure to allergens or causative agents for immunological reactions to occur [ 15 – 17 ].…”

Section: Discussionsupporting

confidence: 91%

“…pylori has been implicated as a pathogenic agent in a variety of disorders other than gastrointestinal diseases including CU [ 15 ]. This organism can be detected easily by a stool antigen test, which meets the requirements of dermatologists treating most patients with CU because it is rapid, noninvasive, cheap, and convenient for pretreatment diagnosis with a high sensitivity of 95% and a specificity of 98% [ 9 ]. The current study aimed to look at the association between CU and H .…”

Section: Discussionmentioning

confidence: 99%

“…Most of the infected people are asymptomatic, and they develop manifestations of peptic ulcer. Extra-gastrointestinal manifestations such as CU, vascular, and autoimmune disorders occur later in life [ 9 ]. CU has continued to be a frustrating condition to both the patient and the care provider and has a significant impact on the patient's well-being especially on sleep, mood, and work.…”

Section: Introductionmentioning

confidence: 99%

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Association between Chronic Urticaria and Helicobacter pylori Infection among Patients Attending a Tertiary Hospital in Tanzania

Dennis

Mavura

Kini

et al. 2020

Dermatology Research and Practice

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Background. Chronic urticaria (CU) is a common skin disease; however, its etiology is rarely recognized. Infection due to Helicobacter pylori (H. pylori) has been shown in some studies to play a significant role in the pathogenesis of CU. Objective. This study was conducted to determine the association between CU and H. pylori infection among patients attending the Regional Dermatology Training Center, Northern Tanzania, from October 2018 to April 2019. Methodology. A matched case-control study that included 55 cases and 55 controls matched by age and sex was conducted. Data were collected through direct interviews, and the results of laboratory investigations were recorded in the extraction sheet. An enzyme-linked immunosorbent assay test was used to detect H. pylori antigen in the stool samples. Conditional logistic regression was used to measure the association between CU and H. pylori. Results. The total number of participants in this study was 110 patients (55 cases and 55 controls), whereby the median age was 31 (IQR 27–45) among controls versus 34 (IQR: 22–46) years among the cases. Both cases and controls had the same number of females and males. There was no significant association between CU and baseline characteristics of the participants. There was an association between CU and H. pylori infection, such that subjects with CU had a higher number of positive H. pylori test (15/55 = 27%) versus controls (6/55 = 10.1%) (p=0.0225). The adjusted odds of CU among patients who were positive for H. pylori were sixfolds higher (OR = 6.9; CI: 1.3–36.2; p=0.021) than those of patients who were negative for H. pylori.Conclusion. There was a strong and significant association between CU and H. pylori infection. We recommend investigating for H. pylori in all cases of CU and conducting further trials on H. pylori eradication.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Chronic Urticaria and Helicobacter pylori Infection among Patients Attending a Tertiary Hospital in Tanzania

Dennis

Mavura

Kini

et al. 2020

Dermatology Research and Practice

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Association between Chronic Urticaria and Helicobacter Pylori Infection in Patients Visiting a Tertiary Hospital

Liaqat¹,

Ibad²,

Khan³

et al. 2022

PJMHS

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Objective: This study aims to demonstrate the association between chronic urticaria and H.pylori infection for effective management of chronic urticaria. Methodology: A case-control study was conducted in the Dermatology Department of Bakhtawar Amin Trust Hospital Multan from 30th Jan 2020 to 30th Jan 2021. The patients who recently visited the inpatient or outpatient ward of the hospital were a part of the study whereas the patients who were administered proton pump inhibitors or any antibiotics in the last 1 month were excluded from the study. The patients diagnosed with chronic urticaria were asked to collect one gram of stool and submit the sample. The sample was stored at -20 Celsius and tested for H.pylori infection. The strength of association between chronic urticaria and H.pylori infection was measured by conditional logistic regression. Two-tailed p values were noted and p<0.05 was regarded as statistically significant Results: The study included 80 patients (40 controls and 40 cases). The median age was 32 years in controls while 35 years in cases. Both groups had a majority (n=56, 70%) of females. More than one half (n=23, 57%) of cases and controls (n=27, 67%) lived in urban region. There was a significant difference between the percentage of those who tested H.Pylori positive and had CU and those who were H.Pylori positive but did not have CU. In subjects infected with H.Pylori risk of CU is six times higher than those not infected Conclusion: Relation between H.Pylori and Chronic urticaria is significant, which indicates H.Pylori tests for diagnosis of CU. Keywords: Chronic Urticaria, H.Pylori, Stool antigen test

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Prevalence of Helicobacter pylori Infection Among Rosacea and Chronic Spontaneous Urticaria Patients in a Tertiary Hospital in Riyadh, Saudi Arabia

Al-Balbeesi¹,

Alsalman²,

Alotaibi³

et al. 2021

Cureus

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Background: The multifactorial nature of rosacea and chronic spontaneous urticaria (CSU) pathogenesis complicates the achievement of satisfactory treatment outcomes. 13C urea breath test (UBT) has been identified as an accurate, non-invasive, and quick procedure to detect the presence of Helicobacter pylori (H. pylori) with high sensitivity and specificity.Objective: In this study, we aim to assess the correlation between H. pylori infection and rosacea and CSU patients.Methods: A cross-sectional, observational study was conducted on patients with rosacea and CSU in the dermatology clinic at King Khalid University Hospital in Riyadh, Saudi Arabia. History and physical examination were performed by a dermatologist. H. pylori 13C-UBT detection was performed in all subjects.Results: In total, 114 patients were included in this current study, with 41 rosacea and 73 urticaria patients. The vast majority of our subjects were females (96.5%). The mean (±SD) age was 42.3 (±12.7). More than half (58.8%) of the examined samples were positive for 13C-UBT; however, positive results were significantly higher in the rosacea patients (73.2%) compared to the urticaria group (50.7%), with a p-value of 0.019. Conclusion:Our findings underline the significant association of H. pylori with rosacea and CSU regardless of the presence or absence of gastrointestinal symptoms. We thus recommend the inclusion of H. pylori testing in the routine workup of CSU and rosacea patients.

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Role of Helicobacter Pylori in Chronic Urticaria among Egyptian Patients with Dyspepsia: A case–control study

Cited by 3 publications

References 23 publications

Association between Chronic Urticaria and Helicobacter pylori Infection among Patients Attending a Tertiary Hospital in Tanzania

Association between Chronic Urticaria and Helicobacter pylori Infection among Patients Attending a Tertiary Hospital in Tanzania

Association between Chronic Urticaria and Helicobacter Pylori Infection in Patients Visiting a Tertiary Hospital

Prevalence of Helicobacter pylori Infection Among Rosacea and Chronic Spontaneous Urticaria Patients in a Tertiary Hospital in Riyadh, Saudi Arabia

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