Role of Helicobacter pylori in ulcer healing and recurrence of gastric and duodenal ulcers in longterm NSAID users. Response to omeprazole dual therapy.

Porro, G. Bianchi; Parente, F.; Imbesi, V.; Montrone, F; Caruso, I

doi:10.1136/gut.39.1.22

Cited by 118 publications

(61 citation statements)

References 18 publications

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“…Some recent studies have shown that the incidence of DU is increased in H. pylori-positive patients taking NSAIDs (91,92). However, in another study H. pylori eradication did not increase the healing of GU and DU associated with long-term NSAID use (93). It has been recently reported that eradication of H. pylori before NSAID therapy strikingly reduces the incidence of ulcer disease in patients being treated with naproxen (750 mg/day).…”

Section: Ajg -November 1998mentioning

confidence: 96%

A guideline for the treatment and prevention of nsaid-induced ulcers

Lanza

1998

The American Journal of Gastroenterology

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Section: Ajg -November 1998mentioning

confidence: 96%

A guideline for the treatment and prevention of nsaid-induced ulcers

Lanza

1998

The American Journal of Gastroenterology

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“…However, nothing may change in these patients even after cure of H. pylori infection, because the therapy for preventing the possible mucosal injury can not be neglected as long as NSAIDs are given. As for the healing of NSAIDulcers, eradication of H. pylori delays ulcer healing when treated with omeprazole (29). Therefore, the eradication therapy should not be done if NSAID-ulcer is in an active stage, which needs conventional anti-ulcer treatment.…”

Section: Should H Pylori Be Eradicated In Nsaid Users?mentioning

confidence: 99%

Has Helicobacter pylori Eradication for Peptic Ulcer Been Overrated?

et al. 2004

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“…Comment: Many studies show that eradication of H. pylori has no effect on treatment of NSAID-induced ulcers [103]. Some reports indicate that H. pylori eradication therapy delays the healing of these ulcers.…”

Section: Cq Does Eradication Of H Pylori Increase the Healing Rate mentioning

confidence: 99%

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

et al. 2016

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The Japanese Society of Gastroenterology (JSGE) revised the evidence-based clinical practice guidelines for peptic ulcer disease in 2014 and has created an English version. The revised guidelines consist of seven items: bleeding gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcer, non-H. pylori, non-nonsteroidal anti-inflammatory drug (NSAID) ulcer, surgical treatment, and conservative therapy for perforation and stenosis. Ninety clinical questions (CQs) were developed, and a literature search was performed for the CQs using the Medline, Cochrane, and Igaku Chuo Zasshi databases between 1983 and June 2012. The guideline was developed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Therapy is initially provided for ulcer complications. Perforation or stenosis is treated with surgery or conservatively. Ulcer bleeding is first treated by endoscopic hemostasis. If it fails, surgery or interventional radiology is chosen. Second, medical therapy is provided. In cases of NSAID-related ulcers, use of NSAIDs is stopped, and anti-ulcer therapy is provided. If NSAID use must continue, the ulcer is treated with a proton pump inhibitor (PPI) or prostaglandin analog. In cases with no NSAID use, H. pylori-positive patients receive eradication and anti-ulcer therapy. If first-line eradication therapy fails, second-line therapy is given. In cases of non-H. pylori, non-NSAID ulcers or H. pyloripositive patients with no indication for eradication therapy, non-eradication therapy is provided. The first choice is PPI therapy, and the second choice is histamine 2-receptor antagonist therapy. After initial therapy, maintenance therapy is provided to prevent ulcer relapse.

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Role of Helicobacter pylori in ulcer healing and recurrence of gastric and duodenal ulcers in longterm NSAID users. Response to omeprazole dual therapy.

Cited by 118 publications

References 18 publications

A guideline for the treatment and prevention of nsaid-induced ulcers

A guideline for the treatment and prevention of nsaid-induced ulcers

Has Helicobacter pylori Eradication for Peptic Ulcer Been Overrated?

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

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