Role of Helicobacter Pylori Eradication in Pregnant Women with Hyperemesis Gravidarum

Abstract

Objective: The aim of this research is to detect the role of eradication of Helicobacter pylori in pregnant women with hyperemesis gravidarum (HG) using modified, high dose, non-teratogenic dual therapy. Study design: Randomized controlled trial. Patients and methods:The study included 156 pregnant women suffering from HG with positive fecal antigen test for Helicobacter pylori. Participants were divided randomly into two groups: group A that received the traditional management for HG (diet instructions, intravenous fluids, electrolyte replacement, antiemetics and vitamins supplementation), and group B that received the previous management for HG plus adding eradication dual therapy for Helicobacter pylori in form of Lansoprazole 30 mg TID + Amoxicillin 1 g TID for 2 weeks and the clinical response to both lines of management was evaluated in both groups two weeks after the start of management. Results: There is a statistically significant difference between both groups as regard clinical response to the used regimen with more clinical improvement in group B. Conclusion: There is an association between Helicobacter pylori infection and hyperemesis gravidarum, allowing us to conclude that Helicobacter pylori should be considered as one of the risk factors of HG. Screening for Helicobacter pylori should be added to the investigations of HG, especially if prolonged or refractory to the traditional management. Modified, high dose, non-teratogenic dual therapy for eradication of Helicobacter pylori could be considered to relieve HG in intractable cases with negligible side effects.

A meta‐analysis of the association between Helicobacter pylori (H. pylori) infection and hyperemesis gravidarum

“…Eradication of H. pylori in infected pregnant women can significantly improve symptoms in HG as illustrated by several case‐control studies . There is no clear clinical guideline for the eradication of H. pylori in pregnancy.…”

The Association between Helicobacter Pylori Infection and Hyperemesis Gravidarum

“…. However, our study had strong point of assessment of the liver functions and serum electrolytes and their correlation with the HEG and H. pylori than Elshazly et al (5) and Mostafa Ahmed et al (9) , who did not correlate the liver functions and serum electrolytes with H. Pylori infection.…”

Association Between Helicobacter pylori, Adverse Gynecological and Pregnancy Outcomes, and Some Cancers: An Overview of Metanalyses

“…Screening should be appended to HG examinations, in particular, if it is prolonged or resistant to traditional treatment. Modified, high-dose, non-teratogenic dual therapy for Hp eradication can relieve HG in incurable cases with minimal complications (30). However, no specific clinical guidelines have been issued to date on the eradication of Hp infection during pregnancy (12) The possible underlying pathogenesis for H. pylori to induce PE can be explained in several ways.…”