Role of habenula and amygdala dysfunction in Parkinson disease patients with punding

Marković, Vladana; Canu, Elisa; Inuggi, Alberto; Petrović, Igor; Stanković, Iva; Imperiale, Francesca; Stojković, Tanja; Kostić, Vladimir; Filippi, Massimo

doi:10.1212/wnl.0000000000004012

Cited by 32 publications

(41 citation statements)

References 34 publications

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“…Considering the subdomains of impulsivity, a positive correlation with both the thalamus and non-planning impulsivity is in line with previous findings showing a correlation between risk taking and activity in subcortical regions 58 . Likewise, the directional correlation between motor impulsivity and reduced right hippocampal volume is in line with a previous report, showing that dysfunction in this region 59,60 impacts hyperactivity and impulsivity 61 . However, careful interpretation is needed because our study was not designed to assess asymmetry or altered basal ganglia-thalamo-cortical structure in impulsivity.…”

Section: Discussionsupporting

confidence: 92%

Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder

Kim

Shin

Myung

et al. 2019

Sci Rep

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Neuroimaging research increasingly suggests there are biological features related to suicidal risk, including brain morphometric features, leading to an elaborate suicide risk assessment. However, few studies have focused on the severity of suicidal ideation and its association with subcortical anatomy in patients with major depressive disorder (MDD). Here, we mainly investigated whether specific structural differences were present in MDD patients with and without suicidal ideation; and supplemented comparison with and without suicidal attempt. We hypothesized that structures associated with suicidal ideation would be derived from a combination of depression and impulsivity. Local atrophy of subcortical structures in 48 patients with MDD (24 with suicidal ideation and 24 without) and 25 age- and sex-matched healthy controls were compared using a surface-based shape analysis method. There was no difference in brain volume between MDD patients with or without suicidal ideations; or MDD patients with or without suicidal attempt. However, the atrophy level in the left pallidum showed a positive correlation with severity of suicidal risk in MDD patients with suicidal ideation. Local atrophy of the left hippocampus, right caudate, and right pallidum had a positive correlation with total impulsivity. These findings possibly suggest that vulnerability to suicidal attempt can be derived from suicidal ideation combined with depression and impulsivity, related to reduced motivational control.

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Section: Discussionsupporting

confidence: 92%

Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder

Kim

Shin

Myung

et al. 2019

Sci Rep

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“…Numerous studies have reported a relationship between punding and a high dose and long duration of treatment with levodopa and DAs 36,54,55 . A lack of dopaminergic terminals and intermittent levodopa administration results in abnormal dopamine release and hyperactivity of the ventral and dorsal striatal circuits, especially in D1 receptors 10,54,56 . The imbalance represented by increased connectivity in the striatum and reduced connectivity with the prefrontal cortical regions involved in the control of executive functions and directed attention may explain the purposeless repetitive behavior that occurs in punding 55,56 .…”

Section: Pundingmentioning

confidence: 99%

Impulse control and related disorders in Parkinson’s disease

Vargas¹,

Cardoso

2018

Arq. Neuro-Psiquiatr.

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Neuropsychiatric disorders are common among patients with Parkinson's disease and may appear in any stage of the disease. However, these disorders often go undiagnosed and receive insufficient treatment. Observations in recent years have revealed that dopamine replacement therapy may lead to the development or worsening of conditions, such as gambling disorder, compulsive sexual behavior, compulsive buying and binge eating, in addition to punding and dopamine dysregulation syndrome. The pathophysiology of these disorders seems to be related to abnormal dopaminergic stimulation of the basal regions of the basal ganglia, especially via nigro-mesolimbic pathways. The aim of the present study was to perform a literature review on impulsivity, impulse control disorders and related conditions among patients with Parkinson's disease, with emphasis on their epidemiology, clinical characteristics and treatment.

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“…In PD patients with impulsive‐compulsive behaviors, a decreased connectivity of the frontoparietal network and a lack of increased sensorimotor functional connectivity were also observed . Additionally, a study found altered connectivity among the crucial nodes of the reward circuit in PD patients with punding (i.e., habenula, amygdala, basal ganglia, frontal cortex) …”

Section: Introductionmentioning

confidence: 99%

Resting‐state Functional MRI in Parkinsonian Syndromes

Filippi

Sarasso

Agosta

2019

Movement Disord Clin Pract

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Background Background: Functional MRI (fMRI) has been widely used to study abnormal patterns of functional connectivity at rest in patients with movement disorders such as idiopathic Parkinson's disease (PD) and atypical parkinsonisms. Methods Methods: This manuscript provides an educational review of the current use of resting-state fMRI in the field of parkinsonian syndromes. ResultsResults: Resting-state fMRI studies have improved the current knowledge about the mechanisms underlying motor and non-motor symptom development and progression in movement disorders. Even if its inclusion in clinical practice is still far away, resting-state fMRI has the potential to be a promising biomarker for early disease detection and prediction. It may also aid in differential diagnosis and monitoring brain responses to therapeutic agents and neurorehabilitation strategies in different movement disorders. ConclusionsConclusions: There is urgent need to identify and validate prodromal biomarkers in PD patients, to perform further studies assessing both overlapping and disease-specific fMRI abnormalities among parkinsonian syndromes, and to continue technical advances to fully realize the potential of fMRI as a tool to monitor the efficacy of chronic therapies.

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Role of habenula and amygdala dysfunction in Parkinson disease patients with punding

Abstract: A breakdown of the connectivity among the crucial nodes of the reward circuit (i.e., habenula, amygdala, basal ganglia, frontal cortex) might be a contributory factor to punding in PD. This study provides potential instruments to detect and monitor punding in patients with PD.

Cited by 32 publications

References 34 publications

Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder

Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder

Impulse control and related disorders in Parkinson’s disease

Resting‐state Functional MRI in Parkinsonian Syndromes

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