Role of H-Ferritin in Radiosensitivity of Human Glioma Cells

Connor, James R.

doi:10.24966/cbt-7546/100006

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Finally, ferritin has been shown to be involved in the resistance of neoplastic cells to anti-cancer treatments (chemotherapy, radiotherapy, immunotherapy and targeted therapy) due to its antioxidant features, which allow tumor cells to survive the stresses exerted by therapies. The elevated expression of both FTH1 and FTL has been reported to correlate with chemo-and radio-resistance in cancer cell lines derived from different types of human tumors, including leukemia [95,96], melanoma [85], glioma [97,98], breast cancer, bladder cancer, lung cancer and prostate cancer [99,100].…”

Section: Ferritinmentioning

confidence: 99%

Iron Metabolism in Cancer and Senescence: A Cellular Perspective

Crescenzi

Leonardi

Pacifico

2023

Biology

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Iron participates in a number of biological processes and plays a crucial role in cellular homeostasis. Alterations in iron metabolism are considered hallmarks of cancer and drivers of aggressive behaviors, such as uncontrolled proliferation, resistance to apoptosis, enhanced metastatic ability, increased cell plasticity and stemness. Furthermore, a dysregulated iron metabolism has been associated with the development of an adverse tumor microenvironment. Alterations in iron metabolism have been described in cellular senescence and in aging. For instance, iron has been shown to accumulate in aged tissues and in age-related diseases. Furthermore, in vitro studies demonstrate increases in iron content in both replicative and stress-induced senescent cells. However, the role, the mechanisms of regulation and dysregulation and the effects of iron metabolism on senescence remain significantly less characterized. In this review, we first provide an overview of iron metabolism and iron regulatory proteins. Then, we summarize alterations in iron homeostasis in cancer and senescence from a cellular point of view.

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