Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer

Lin, Caizhao; Cai, Xiaona; Zhang, Jing; Wang, Weibing; Sheng, Qinsong; Hua, Hanju; Zhou, Xile

doi:10.1159/000494052

Cited by 85 publications

(62 citation statements)

References 52 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hatakka et al demonstrated that the consumption of certain strains of probiotic bacteria can reduce the activity of intestinal enzymes that can convert aromatic hydrocarbons and amines in active carcinogens and prevent colon cancer [169]. The peptidoglycan, polysaccharide and secreted glycoproteins on the surface of probiotic bacteria, combined with carcinogenic mutagens could be responsible for biotransformation aiming to detoxification [170].…”

Section: Probioticsmentioning

confidence: 99%

The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response

Sánchez-Alcoholado

Ramos‐Molina

Otero

et al. 2020

Cancers

195

123

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota can alter CRC susceptibility and progression by modulating mechanisms such as inflammation and DNA damage, and by producing metabolites involved in tumor progression or suppression. Dysbiosis of gut microbiota has been observed in patients with CRC, with a decrease in commensal bacterial species (butyrate-producing bacteria) and an enrichment of detrimental bacterial populations (pro-inflammatory opportunistic pathogens). CRC is characterized by altered production of bacterial metabolites directly involved in cancer metabolism including short-chain fatty acids and polyamines. Emerging evidence suggests that diet has an important impact on the risk of CRC development. The intake of high-fiber diets and the supplementation of diet with polyunsaturated fatty acids, polyphenols and probiotics, which are known to regulate gut microbiota, could be not only a potential mechanism for the reduction of CRC risk in a primary prevention setting, but may also be important to enhance the response to cancer therapy when used as adjuvant to conventional treatment for CRC. Therefore, a personalized modulation of the pattern of gut microbiome by diet may be a promising approach to prevent the development and progression of CRC and to improve the efficacy of antitumoral therapy.

show abstract

Section: Probioticsmentioning

confidence: 99%

The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response

Sánchez-Alcoholado

Ramos‐Molina

Otero

et al. 2020

Cancers

195

123

View full text Add to dashboard Cite

show abstract

“…This implies a change in bacterial populations within the gut of colorectal cancer patients, which may include an increase in pathogenic cancer-associated bacteria and a loss of protective anti-cancer bacteria. Supporting this, comparisons of gut microbiota between normal individual and colorectal cancer patients reveals that the predominant flora in colorectal cancer are pathogenic bacteria such as Escherichia coli strains harboring polyketide synthase (pks) pathogenicity islands, enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum [38][39][40]. On the other hand, beneficial strains of bacteria such as butyrate-producing species have been shown to be under-represented in colorectal cancers, which is consistent with a reduced amount butyrate being seen in the stool of colorectal cancer patients compared to normal individuals [41].…”

Section: Gut Microbiota and Colorectal Cancermentioning

confidence: 94%

Influence of Iron on the Gut Microbiota in Colorectal Cancer

et al. 2020

View full text Add to dashboard Cite

Perturbations of the colonic microbiota can contribute to the initiation and progression of colorectal cancer, leading to an increase in pathogenic bacteria at the expense of protective bacteria. This can contribute to disease through increasing carcinogenic metabolite/toxin production, inducing inflammation, and activating oncogenic signaling. To limit disease progression, external factors that may influence the colonic microbiota need to be considered in patients with colorectal cancer. One major factor that can influence the colonic microbiota is iron. Iron is an essential micronutrient that is required by both prokaryotes and eukaryotes for cellular function. Most pathogenic bacteria have heightened iron acquisition mechanisms and therefore tend to outcompete protective bacteria for free iron. Colorectal cancer patients often present with anemia due to iron deficiency, and thus they require iron therapy. Depending upon the route of administration, iron therapy has the potential to contribute to a procarciongenic microbiota. Orally administered iron is the common treatment for anemia in these patients but can lead to an increased gut iron concentration. This suggests the need to reassess the route of iron therapy in these patients. Currently, this has only been assessed in murine studies, with human trials being necessary to unravel the potential microbial outcomes of iron therapy.

show abstract

“…④One of the key mechanisms of tumor immunotherapy is to regulate the immune system of the patient through gut microbiota. This process is also closely related to this signaling pathway, and the anti-CRC effect of the probiotic mixture is mediated by increasing TLR2 signaling in the CRC rat model [ 77 ].…”

Section: Correlation Between Intestinal Flora and Cancerous Toxinmentioning

confidence: 99%

The Relationship between Prevention and Treatment of Colorectal Cancer and Cancerous Toxin Pathogenesis Theory Basing on Gut Microbiota

Sang

Qiu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Gut microbiota is a diverse consortium of bacteria, fungi, protozoa, and viruses in the gut of all mammals. Gut microbiota remains in steady state under normal conditions. Changes in the internal and external environment may cause gut Microbiota to be out of tune. Malignant tumors are one of the major diseases currently endangering human health. CRC (colorectal cancer) has a significant upward trend in morbidity and mortality in many parts of the world. Technological advances have not yet brought about a breakthrough in the efficacy of CRC. The development of colon cancer is closely related to gut microbiota imbalance. According to more than 60 years of clinical practice, Professor Zhongying Zhou first proposed the pathogenesis theory of “cancerous toxin” in the 1990s and believed that cancerous toxin was a key pathogenesis of tumor development. Under the guidance of the theory of cancerous toxin, combined with clinical practice, Professor Zhou created an effective anticancer Chinese herbal compound, Jiedu Xiaoai Prescription. This paper summarizes recent hotspots related to gut microbiota and the occurrence, development, and prevention of colon cancer at home and abroad. The relationship between gut microbiota and cancerous toxin theory is proposed, and the feasibility of further studying the biological basis of cancerous toxin pathogenesis theory from the perspective of gut microbiota is pointed out.

show abstract

Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer

Cited by 85 publications

References 52 publications

The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response

The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response

Influence of Iron on the Gut Microbiota in Colorectal Cancer

The Relationship between Prevention and Treatment of Colorectal Cancer and Cancerous Toxin Pathogenesis Theory Basing on Gut Microbiota

Contact Info

Product

Resources

About