Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health

Chambers, Edward S.; Preston, Tom; Frost, Gary; Morrison, Douglas J.

doi:10.1007/s13668-018-0248-8

Cited by 483 publications

(366 citation statements)

References 91 publications

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“…The metabolic activity of A. muciniphila on the host metabolic physiology has also been determined to interact directly with several lipid metabolic substances, including changing the endotoxin level (Ozkul et al, 2017) and short-chain fatty acid (SCFA) production (Ottman et al, 2017b), as well as increasing fatty acid oxidation in the intestine and adipose tissue (Lukovac et al, 2014). As a producer of SCFAs, A. muciniphila has been reported to convert dietary fiber into acetate, propionate, and butyrate; these metabolites can have effects on glucose and lipid homeostasis (Chambers et al, 2018). The SCFA production in the distal ileum induced the action of the various transcription factors to control lipid metabolism and growth; for example, propionate and butyrate stimulation led to an obvious increase in fasting-induced adipocyte factor (Fiaf) production and decreased Gpr43, histone deacetylase (HDAC), and PPARγ expression.…”

Section: Influence Of Akkermansia Muciniphila On Lipid Desregulationmentioning

confidence: 99%

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

et al. 2020

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Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a worldwide epidemic and are intimately linked to diet. The gut microbiota interaction has been pointed to as a hot topic of research in the treatment of obesity and related metabolic diseases by influencing energy metabolism and the immune system. In terms of the novel beneficial microbes identified, Akkermansia muciniphila (A. muciniphila) colonizes the mucosa layer of the gut and modulates basal metabolism. A. muciniphila is consistently correlated with obesity. The causal beneficial impact of A. muciniphila treatment on obesity is coming to light, having been proved by a variety of animal models and human studies. A. muciniphila has been characterized as a beneficial player in body metabolism and has great prospects for treatments of the metabolic disorders associated with obesity, as well as being considered for next-generation therapeutic agents. This paper aimed to investigate the basic mechanism underlying the relation of A. muciniphila to obesity and its host interactions, as identified in recent discoveries, facilitating the establishment of the causal relationship in A. muciniphila-associated therapeutic supplement in humans.

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Section: Influence Of Akkermansia Muciniphila On Lipid Desregulationmentioning

confidence: 99%

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

et al. 2020

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“…Recent studies suggest that SCFAs exert multiple beneficial effects on mammalian energy metabolism and may beneficially influence inflammation status in the circulation. [50] The analyses was performed in Metacore. Transcription factor in italics are presented in the list of downregulated probe sets.…”

Section: Fdr [%]mentioning

confidence: 99%

Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub‐Study

Myhrstad

Mello

Dahlman

et al. 2019

Molecular Nutrition Food Res

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Scope To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p‐value < 0.05). Twenty‐five of these are significantly regulated (FDR q‐value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF‐κB, are downregulated in the healthy Nordic diet group. Conclusion These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.

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“…Recent studies of gut microbiota have developed extremely fast and their composition and products have been associated with human physical and mental health [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Several sophistic approaches have been established to study gut microbiota, including high-throughput 16S rRNA sequencing, metagenomics, and massive bacterial cloning [19][20][21][22][23][24][25][26][27].…”

Section: Ld-like Structures In Intestinal Bacteriamentioning

confidence: 99%

Identification of Lipid Droplets in Gut Microbiota

Zhang

Zhou

et al. 2020

Preprint

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Recent research has accumulating evidence to support that gut microbiota can be a newly discovered organ/tissue for humans. Although the functions of gut microbiota have been linked to almost all aspects of human physiological, most findings so far are still either belonged to correlational research or at preliminary stage of causal study due to the complexity of gut microbiota as well as lack of proper tools and methods. Thus, development of new approaches is essential and necessary. Lipid droplet is a cellular organelle governing cell lipid homeostasis that is directly related to human metabolic syndromes. Previously we and other groups found lipid droplets in several bacterial strains. We wonder if gut bacteria have lipid droplets. If so, these bacteria may play key roles to regulate gut lipid content, remove unnecessary lipids and produce useful lipid molecules for host. Here we identified lipid droplet-like structures in freshly isolated bacteria from mouse small and large intestines, as well as mouse and human feces. We also purified and analyzed lipid droplets from a cloned human gut bacterium Streptomyces thermovulgaris. Together, we demonstrate the existence of lipid droplets in gut microbiota and established an approach to study them. Results and Discussion LD-like structures in intestinal bacteriaRecent studies of gut microbiota have developed extremely fast and their composition and products have been associated with human physical and mental health [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Several sophistic approaches have been established to study gut microbiota, including high-throughput 16S rRNA sequencing, metagenomics, and massive bacterial cloning [19][20][21][22][23][24][25][26][27]. Since the number and species of gut microbiota are too huge, the resulting complexity is an obscure that makes their functions remain

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Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health

Cited by 483 publications

References 91 publications

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub‐Study

Identification of Lipid Droplets in Gut Microbiota

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