Role of gut microbiota-derived signals in the regulation of gastrointestinal motility

Zheng, Zhipeng; Tang, Jingyi; Hu, Yingnan; Zhang, Wei

doi:10.3389/fmed.2022.961703

Cited by 15 publications

(12 citation statements)

References 120 publications

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“…17,44 Also important in this context, microbial metabolites, such as short-chain fatty acids (SCFAs) can modulate blood pressure [46][47][48] and colonic contractile properties, being altered in both patients with GI dysmotility (including IBS-C) and hypertension. 17,[49][50][51] Significant association with MACE was observed for all constipation definitions analysed in the current study. Notably, the strength of association was more pronounced in the cohort identified through hospital-inpatient records (based on the ICD K59.0 code) compared to other constipation surrogates and phenotypes, including laxative users, functional constipation, and IBS-C (which involves chronic abdominal pain and/or discomfort).…”

supporting

confidence: 48%

Constipation is associated with an increased risk of major adverse cardiac events in a UK population

Zheng,

Camargo Tavares,

D’Amato

et al. 2024

Preprint

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Background: Traditional cardiovascular risk factors, including hypertension, only explain part of major adverse cardiac events (MACE). Understanding what other risk factors contribute to MACE is essential for prevention. Constipation shares common risk factors with hypertension and is associated with an increased risk of several cardiovascular diseases. We hypothesised that constipation is an under-appreciated risk factor for MACE. Methods: We used the population healthcare and genomic data in the UK Biobank (UKBB) (n=408,354) to study the contribution of constipation (ICD-10 K59.0) to the risk of MACE, defined by any episode of acute coronary syndrome (ACS), ischemic stroke and heart failure (HF). Analyses were controlled for traditional cardiovascular risk factors. We also assessed genetic correlations (rg) between constipation and MACE. Results: Constipation cases (N=23,814) exhibited significantly higher risk of MACE compared to those with normal bowel habits (OR=2.15, P<1.00x10-300). Constipation was also significantly associated with individual MACE subgroups, in order: HF (OR=2.72, P<1.00x10-300), ischemic stroke (OR=2.36, P=2.02x10-230), and ACS (OR=1.62, P=5.82x10-113). In comparison with constipation-free hypertensive patients, hypertensive patients with constipation showed significantly higher odds of MACE (OR=1.68, P=1.05x10-136) and a 34% increased risk of death (P=2.3x10-50) after adjustment for medications that affect gut motility and other traditional cardiovascular risk factors. Finally, we detected positive genetic correlations between constipation and MACE subgroups ACS (rg=0.27, P=2.12x10-6), ischemic stroke (rg=0.23, P=0.011), and HF (rg=0.21, P=0.0062). Conclusion: We identified constipation as a potential risk factor independently associated with higher MACE prevalence. These findings warrant further studies on their causal relationship and identification of pathophysiological mechanisms.

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supporting

confidence: 48%

Constipation is associated with an increased risk of major adverse cardiac events in a UK population

Zheng,

Camargo Tavares,

D’Amato

et al. 2024

Preprint

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“…12 As we all know, gut microbiota plays a vital role in regulating gastrointestinal physiology, especially intestinal motility. 13 Recent studies have shown that constipated mice are always accompanied with gut microbiota disorders. 14 Specifically, the Firmicutes/Bacteroidota (F/B) ratio is typically reduced at the phylum level in constipated mice.…”

Section: ■ Introductionmentioning

confidence: 99%

“…As we all know, gut microbiota plays a vital role in regulating gastrointestinal physiology, especially intestinal motility . Recent studies have shown that constipated mice are always accompanied with gut microbiota disorders .…”

Section: Introductionmentioning

confidence: 99%

Fu Brick Tea Alleviates Constipation via Regulating the Aquaporins-Mediated Water Transport System in Association with Gut Microbiota

Zhang

et al. 2023

J. Agric. Food Chem.

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This study aimed to investigate the amendatory effects of Fu brick tea aqueous extract (FTE) on constipation and its underlying molecular mechanism. The administration of FTE by oral gavage (100 and 400 mg/kg•bw) for 5 weeks significantly increased fecal water content, improved difficult defecation, and enhanced intestinal propulsion in loperamide (LOP)-induced constipated mice. FTE also reduced colonic inflammatory factors, maintained the intestinal tight junction structure, and inhibited colonic Aquaporins (AQPs) expression, thus normalizing the intestinal barrier and colonic water transport system of constipated mice. 16S rRNA gene sequence analysis results indicated that two doses of FTE increased the Firmicutes/Bacteroidota (F/B) ratio at the phylum level and increased the relative abundance of Lactobacillus from 5.6 ± 1.3 to 21.5 ± 3.4% and 28.5 ± 4.3% at the genus level, subsequently resulting in a significant elevation of colonic contents short-chain fatty acids levels. The metabolomic analysis demonstrated that FTE improved levels of 25 metabolites associated with constipation. These findings suggest that Fu brick tea has the potential to alleviate constipation by regulating gut microbiota and its metabolites, thereby improving the intestinal barrier and AQPs-mediated water transport system in mice.

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“…This dysmotility can range from malabsorption, which is associated with increased motility, to postoperative ileus (POI). Gut microbiota plays a significant role in the regulation of GI physiology, particularly GI motility (Zheng et al, 2022).…”

Section: Gastrointestinal Dysmotilitymentioning

confidence: 99%

The implication of gut microbiota in recovery from gastrointestinal surgery

Zheng

Tang

et al. 2023

Front. Cell. Infect. Microbiol.

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Recovery from gastrointestinal (GI) surgery is often interrupted by the unpredictable occurrence of postoperative complications, including infections, anastomotic leak, GI dysmotility, malabsorption, cancer development, and cancer recurrence, in which the implication of gut microbiota is beginning to emerge. Gut microbiota can be imbalanced before surgery due to the underlying disease and its treatment. The immediate preparations for GI surgery, including fasting, mechanical bowel cleaning, and antibiotic intervention, disrupt gut microbiota. Surgical removal of GI segments also perturbs gut microbiota due to GI tract reconstruction and epithelial barrier destruction. In return, the altered gut microbiota contributes to the occurrence of postoperative complications. Therefore, understanding how to balance the gut microbiota during the perioperative period is important for surgeons. We aim to overview the current knowledge to investigate the role of gut microbiota in recovery from GI surgery, focusing on the crosstalk between gut microbiota and host in the pathogenesis of postoperative complications. A comprehensive understanding of the postoperative response of the GI tract to the altered gut microbiota provides valuable cues for surgeons to preserve the beneficial functions and suppress the adverse effects of gut microbiota, which will help to enhance recovery from GI surgery.

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Role of gut microbiota-derived signals in the regulation of gastrointestinal motility

Cited by 15 publications

References 120 publications

Constipation is associated with an increased risk of major adverse cardiac events in a UK population

Constipation is associated with an increased risk of major adverse cardiac events in a UK population

Fu Brick Tea Alleviates Constipation via Regulating the Aquaporins-Mediated Water Transport System in Association with Gut Microbiota

The implication of gut microbiota in recovery from gastrointestinal surgery

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